| 29 Aug 21 | r01  | CalahorraCalahorra | 0 - 0 | UD LogroñésUD Logroñés |
| |
| 04 Sep 21 | r02  | UD LogroñésUD Logroñés | 1 - 0 | SantanderSantander |
| |
| 11 Sep 21 | r03 | ZamoraZamora | 1 - 4 | UD LogroñésUD Logroñés |
| |
| 19 Sep 21 | r04 | UD LogroñésUD Logroñés | 1 - 0 | Real UniónReal Unión |
| |
| 26 Sep 21 | r05 | Athletic Bilbao BAthletic Bilb | 3 - 1 | UD LogroñésUD Logroñés |
| |
| 02 Oct 21 | r06 | UD LogroñésUD Logroñés | 1 - 0 | SS ReyesSS Reyes |
| |
| 10 Oct 21 | r07 | UD LogroñésUD Logroñés | 0 - 1 | SD LogroñésSD Logroñés |
| |
| 17 Oct 21 | r08 | Inter de MadridInter de Madr | 2 - 2 | UD LogroñésUD Logroñés |
| |
| 23 Oct 21 | r09 | UD LogroñésUD Logroñés | 1 - 0 | TalaveraTalavera |
| |
| 31 Oct 21 | r10 | Celta Vigo BCelta Vigo B | 0 - 1 | UD LogroñésUD Logroñés |
| |
| 07 Nov 21 | r11 | UD LogroñésUD Logroñés | 0 - 1 | La CorunaLa Coruna |
| |
| 14 Nov 21 | r12 | BadajozBadajoz | 1 - 2 | UD LogroñésUD Logroñés |
| |
| 21 Nov 21 | r13 | TudelanoTudelano | 0 - 0 | UD LogroñésUD Logroñés |
| |
| 26 Nov 21 | r14 | UD LogroñésUD Logroñés | 3 - 2 | Valladolid PromesasValladolid Pr |
| |
| 05 Dec 21 | r15 | Rayo MajadahondaRayo Majadaho | 1 - 0 | UD LogroñésUD Logroñés |
| |
| 12 Dec 21 | r16 | UD LogroñésUD Logroñés | 1 - 3 | ExtremaduraExtremadura |
| |
| 19 Dec 21 | r17 | Unionistas de SalamancaUnionistas de | 4 - 0 | UD LogroñésUD Logroñés |
| |
| 08 Jan 22 | r18 | UD LogroñésUD Logroñés | 0 - 0 | LeonesaLeonesa |
| |
| 23 Jan 22 | r19 | Racing Club de FerrolRacing Club d | 0 - 1 | UD LogroñésUD Logroñés |
| |
| 27 Jan 22 | r20 | UD LogroñésUD Logroñés | 1 - 0 | CalahorraCalahorra |
| |
| 30 Jan 22 | r21 | SS ReyesSS Reyes | 1 - 1 | UD LogroñésUD Logroñés |
| |
| 06 Feb 22 | r22 | UD LogroñésUD Logroñés | 1 - 0 | Athletic Bilbao BAthletic Bilb |
| |
| 12 Feb 22 | r23 | Real UniónReal Unión | 1 - 1 | UD LogroñésUD Logroñés |
| |
| 19 Feb 22 | r24 | UD LogroñésUD Logroñés | 0 - 0 | Celta Vigo BCelta Vigo B |
| |
| 26 Feb 22 | r25 | UD LogroñésUD Logroñés | 0 - 1 | Rayo MajadahondaRayo Majadaho |
| |
| 06 Mar 22 | r26 | Valladolid PromesasValladolid Pr | 0 - 2 | UD LogroñésUD Logroñés |
| |
| 11 Mar 22 | r27 | UD LogroñésUD Logroñés | 2 - 1 | Unionistas de SalamancaUnionistas de |
| |
| 20 Mar 22 | r28 | ExtremaduraExtremadura | 0 - 2 | UD LogroñésUD Logroñés |
| |
| 26 Mar 22 | r29 | UD LogroñésUD Logroñés | 1 - 1 | Inter de MadridInter de Madr |
| |
| 02 Apr 22 | r30 | TalaveraTalavera | 2 - 0 | UD LogroñésUD Logroñés |
| |
| 08 Apr 22 | r31 | UD LogroñésUD Logroñés | 1 - 0 | TudelanoTudelano |
| |
| 16 Apr 22 | r32 | SantanderSantander | 1 - 0 | UD LogroñésUD Logroñés |
| |
| 23 Apr 22 | r33 | UD LogroñésUD Logroñés | 1 - 2 | Racing Club de FerrolRacing Club d |
| |
| 30 Apr 22 | r34 | La CorunaLa Coruna | 3 - 0 | UD LogroñésUD Logroñés |
| |
| 08 May 22 | r35 | UD LogroñésUD Logroñés | 4 - 1 | ZamoraZamora |
| |
| 14 May 22 | r36 | SD LogroñésSD Logroñés | 3 - 2 | UD LogroñésUD Logroñés |
| |
| 21 May 22 | r37 | UD LogroñésUD Logroñés | 1 - 0 | BadajozBadajoz |
| |
| 28 May 22 | r38 | LeonesaLeonesa | 1 - 2 | UD LogroñésUD Logroñés |
Team 2021-2022 Schedules
Arenas Club
Athletic Bilbao B
Barakaldo
Cacereño
CD Coria
Cultural Leonesa
Deportivo Fabril
Extremadura
Lugo
Mérida
Mirandés
Ponferradina
Pontevedra
Racing Club de Ferrol
Real Avilés Industrial
Real Unión
UD Logroñés
UD Ourense
Unionistas de Salamanca
Zamora
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