| 27 Jun 25 | r19        | Houston FCHouston FC | 2 - 1 | Lonestar SCLonestar SC |
| 28 Jun 25 | r19        | AC ConnecticutAC Connecticu | 2 - 1 | Boston BoltsBoston Bolts |
| 28 Jun 25 | r19        | St. Petersburg FCSt. Petersbur | 5 - 0 | FC Miami CityFC Miami City |
| 28 Jun 25 | r19        | Inter GainesvilleInter Gainesv | 2 - 0 | Brave SCBrave SC |
| 28 Jun 25 | r19        | Morris EliteMorris Elite | 0 - 2 | Cedar Stars RushCedar Stars R |
| 28 Jun 25 | r19        | Staten Island AthleticStaten Island | 1 - 1 | Westchester FlamesWestchester F |
| 28 Jun 25 | r19        | Black Rock FCBlack Rock FC | 3 - 0 | Albany RushAlbany Rush |
| 28 Jun 25 | r19        | Salem CitySalem City | 2 - 1 | Charlotte Independence IICharlotte Ind |
| 28 Jun 25 | r19        | Reading UnitedReading Unite | 4 - 2 | Lehigh Valley UnitedLehigh Valley |
| 28 Jun 25 | r19        | Delaware FCDelaware FC | 1 - 0 | Real Central New JerseyReal Central |
| 28 Jun 25 | r19        | Ocean City Nor'eastersOcean City No | 3 - 3 | West Chester United IIWest Chester |
| 28 Jun 25 | r19        | East Atlanta Dutch LionsEast Atlanta | 1 - 0 | Birmingham Legion 2Birmingham Le |
| 28 Jun 25 | r19        | Sarasota ParadiseSarasota Para | 3 - 0 | Weston FCWeston FC |
| 28 Jun 25 | r19        | Miami ACMiami AC | 0 - 1 | Kings Hammer Sun CityKings Hammer |
| 28 Jun 25 | r19        | Athens UnitedAthens United | 0 - 0 | Asheville City SCAsheville Cit |
| 29 Jun 25 | r19        | AC Houston SurAC Houston Su | 1 - 1 | Hill Country LobosHill Country |
| 29 Jun 25 | r19        | Louisiana KreweLouisiana Kre | 1 - 1 | Mississippi BrillaMississippi B |
| 29 Jun 25 | r19        | Twin City ToucansTwin City Tou | 1 - 4 | GFI AcademyGFI Academy |
| 29 Jun 25 | r19        | Tobacco RoadTobacco Road | 1 - 3 | North Carolina FC U23North Carolin |
| 06 Jul 25 | r19        | Redlands FCRedlands FC | 7 - 0 | Southern California EagleSouthern Cali |
| 06 Jul 25 | r19        | Davis LegacyDavis Legacy | 1 - 3 | Marin FC LegendsMarin FC Lege |
| 06 Jul 25 | r19        | West Seattle JunctionWest Seattle | 2 - 1 | Snohomish UnitedSnohomish Uni |
| 07 Jul 25 | r19        | FC OlympiaFC Olympia | 5 - 1 | Tacoma StarsTacoma Stars |
| 07 Jul 25 | r19        | City SCCity SC | 0 - 1 | AMSG FCAMSG FC |
| 09 Jul 25 | r19        | West Seattle JunctionWest Seattle | 4 - 3 | Bigfoot FCBigfoot FC |
| 09 Jul 25 | r19        | Midlakes UnitedMidlakes Unit | 2 - 1 | Lane UnitedLane United |
| 10 Jul 25 | r19        | Snohomish UnitedSnohomish Uni | 5 - 1 | Tacoma StarsTacoma Stars |
| 10 Jul 25 | r19        | City SCCity SC | 4 - 1 | Southern California EagleSouthern Cali |
| 10 Jul 25 | r19        | RKC Third CoastRKC Third Coa | 3 - 1 | Minneapolis CityMinneapolis C |
| 10 Jul 25 | r19        | Portland BangersPortland Bang | 1 - 0 | Ballard FCBallard FC |
| 10 Jul 25 | r19        | Toledo VillaToledo Villa | 2 - 3 | Cleveland ForceCleveland For |
| 11 Jul 25 | r19        | Rochester FCRochester FC | 5 - 0 | St. Croix SCSt. Croix SC |
| 12 Jul 25 | r19        | Lexington SC IILexington SC | 1 - 1 | West Virginia UnitedWest Virginia |
| 12 Jul 25 | r19        | Northern IndianaNorthern Indi | 1 - 1 | Union FC MacombUnion FC Maco |
| 12 Jul 25 | r19        | Minneapolis CityMinneapolis C | 4 - 2 | Sueño FCSueño FC |
| 12 Jul 25 | r19        | Flint City BucksFlint City Bu | 4 - 0 | Lansing City FootballLansing City |
| 12 Jul 25 | r19        | Oakland CountyOakland Count | 0 - 0 | Kalamazoo FCKalamazoo FC |
| 12 Jul 25 | r19        | Dayton Dutch LionsDayton Dutch | 1 - 0 | Kings Hammer ColumbusKings Hammer |
| 12 Jul 25 | r19        | FC BuffaloFC Buffalo | 4 - 1 | Erie Sports CenterErie Sports C |
| 12 Jul 25 | r19        | Brave SCBrave SC | 7 - 1 | Brooke HouseBrooke House |