| 09 May 21 | r02  | North Texas SCNorth Texas S | 0 - 1 | Chattanooga Red Wolves SCChattanooga R |
| |
| 17 May 21 | r03 | New England Revolution IINew England R | 2 - 2 | Chattanooga Red Wolves SCChattanooga R |
| 23 May 21 | r03 | Chattanooga Red Wolves SCChattanooga R | 2 - 1 | Fort Lauderdale CFFort Lauderda |
| |
| 30 May 21 | r04 | Chattanooga Red Wolves SCChattanooga R | 2 - 1 | Richmond KickersRichmond Kick |
| 06 Jun 21 | r04 | Tormenta FCTormenta FC | 1 - 0 | Chattanooga Red Wolves SCChattanooga R |
| |
| 13 Jun 21 | r05 | FC TucsonFC Tucson | 2 - 3 | Chattanooga Red Wolves SCChattanooga R |
| |
| 21 Jun 21 | r06 | Chattanooga Red Wolves SCChattanooga R | 3 - 2 | North Carolina FCNorth Carolin |
| 27 Jun 21 | r06 | Chattanooga Red Wolves SCChattanooga R | 1 - 1 | Greenville Triumph SCGreenville Tr |
| |
| 04 Jul 21 | r07 | Union OmahaUnion Omaha | 1 - 1 | Chattanooga Red Wolves SCChattanooga R |
| |
| 11 Jul 21 | r08 | Chattanooga Red Wolves SCChattanooga R | 2 - 2 | FC TucsonFC Tucson |
| 15 Jul 21 | r08 | Chattanooga Red Wolves SCChattanooga R | 2 - 1 | Tormenta FCTormenta FC |
| 18 Jul 21 | r08 | North Texas SCNorth Texas S | 1 - 1 | Chattanooga Red Wolves SCChattanooga R |
| |
| 25 Jul 21 | r09 | Chattanooga Red Wolves SCChattanooga R | 1 - 1 | Greenville Triumph SCGreenville Tr |
| 01 Aug 21 | r09 | Chattanooga Red Wolves SCChattanooga R | 1 - 1 | Forward Madison FCForward Madis |
| |
| 11 Aug 21 | r10 | North Carolina FCNorth Carolin | 1 - 4 | Chattanooga Red Wolves SCChattanooga R |
| |
| 18 Aug 21 | r11  | Chattanooga Red Wolves SCChattanooga R | 1 - 1 | North Texas SCNorth Texas S |
| 22 Aug 21 | r11 | Chattanooga Red Wolves SCChattanooga R | 1 - 0 | Union OmahaUnion Omaha |
| |
| 27 Aug 21 | r12 | Toronto FC IIToronto FC II | 0 - 0 | Chattanooga Red Wolves SCChattanooga R |
| |
| 05 Sep 21 | r13 | Fort Lauderdale CFFort Lauderda | 0 - 0 | Chattanooga Red Wolves SCChattanooga R |
| 09 Sep 21 | r13 | Chattanooga Red Wolves SCChattanooga R | 1 - 0 | North Texas SCNorth Texas S |
| 12 Sep 21 | r13 | Greenville Triumph SCGreenville Tr | 1 - 0 | Chattanooga Red Wolves SCChattanooga R |
| |
| 19 Sep 21 | r14 | Chattanooga Red Wolves SCChattanooga R | 3 - 1 | North Carolina FCNorth Carolin |
| 26 Sep 21 | r14 | Chattanooga Red Wolves SCChattanooga R | 0 - 1 | New England Revolution IINew England R |
| |
| 02 Oct 21 | r15 | Richmond KickersRichmond Kick | 1 - 0 | Chattanooga Red Wolves SCChattanooga R |
| |
| 09 Oct 21 | r16 | North Carolina FCNorth Carolin | 2 - 3 | Chattanooga Red Wolves SCChattanooga R |
| 17 Oct 21 | r16 | Chattanooga Red Wolves SCChattanooga R | 1 - 2 | Toronto FC IIToronto FC II |
| |
| 24 Oct 21 | r17 | Greenville Triumph SCGreenville Tr | 0 - 0 | Chattanooga Red Wolves SCChattanooga R |
| 31 Oct 21 | r17 | Forward Madison FCForward Madis | 2 - 1 | Chattanooga Red Wolves SCChattanooga R |
| |
| 06 Nov 21 | r00 | Chattanooga Red Wolves SCChattanooga R | 2 - 1 | North Texas SCNorth Texas S |
| 14 Nov 21 | r00 | Greenville Triumph SCGreenville Tr | 2 - 0 | Chattanooga Red Wolves SCChattanooga R |
Team 2021 Schedules
AC Boise
AV Alta FC
Charlotte Independence
Chattanooga Red Wolves
Corpus Christi FC
FC Naples
Fort Wayne FC
Forward Madison
Greenville Triumph
New York Cosmos
One Knoxville
Portland Hearts of Pine
Richmond Kickers
Sarasota Paradise
South Georgia Tormenta
Spokane Velocity
Union Omaha
Westchester SC
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