| 05 Jul 22 | Qualifier   | Gżira UnitedGżira United | 1 - 1 | Atlètic d'EscaldesAtlètic d'Esc |
| 05 Jul 22 | Qualifier | St JosephsSt Josephs | 0 - 0 | LarneLarne |
| 06 Jul 22 | Qualifier  | Inter TurkuInter Turku | 1 - 0 | DritaDrita |
| 06 Jul 22 | Qualifier | VikingurVikingur | 1 - 0 | Europa FCEuropa FC |
| 07 Jul 22 | Qualifier | AlashkertAlashkert | 1 - 0 | Ħamrun SpartansĦamrun Sparta |
| 07 Jul 22 | Qualifier | KuPS KuopioKuPS Kuopio | 2 - 0 | Dila GoriDila Gori |
| 07 Jul 22 | Qualifier | UE Santa ColomaUE Santa Colo | 0 - 1 | BreidablikBreidablik |
| 07 Jul 22 | Qualifier | FK PanevėžysFK Panevėžys | 0 - 0 | FC MilsamiFC Milsami |
| 07 Jul 22 | Qualifier | Sfântul Gheorghe SuruceniSfântul Gheor | 1 - 2 | NŠ MuraNŠ Mura |
| 07 Jul 22 | Qualifier | Borac Banja LukaBorac Banja L | 2 - 0 | B36 TorshavnB36 Torshavn |
| 07 Jul 22 | Qualifier | Olimpija LjubljanaOlimpija Ljub | 1 - 1 | FC 03 DifferdangeFC 03 Differd |
| 07 Jul 22 | Qualifier | Saburtalo TbilisiSaburtalo Tbi | 0 - 1 | PartizaniPartizani |
| 07 Jul 22 | Qualifier | Pogon SzczecinPogon Szczeci | 4 - 1 | KR ReykjavikKR Reykjavik |
| 07 Jul 22 | Qualifier | Bruno-'s MagpiesBruno-'s Magp | 2 - 1 | CrusadersCrusaders |
| 07 Jul 22 | Qualifier | FC Flora TallinFC Flora Tall | 1 - 0 | SJK SeinajokiSJK Seinajoki |
| 07 Jul 22 | Qualifier | MFK RužomberokMFK Ružombero | 2 - 0 | Kauno ŽalgirisKauno Žalgiri |
| 07 Jul 22 | Qualifier | Dinamo TbilisiDinamo Tbilis | 2 - 3 | Paide LinnameeskondPaide Linname |
| 07 Jul 22 | Qualifier | Floriana FCFloriana FC | 0 - 0 | Petrocub HînceștiPetrocub Hînc |
| 07 Jul 22 | Qualifier | Lechia GdańskLechia Gdańsk | 4 - 1 | Akademija PandevAkademija Pan |
| 07 Jul 22 | Qualifier | Derry CityDerry City | 0 - 2 | Riga FCRiga FC |
| 07 Jul 22 | Qualifier | LaciLaci | 0 - 0 | Iskra DanilovgradIskra Danilov |
| 07 Jul 22 | Qualifier | BalaBala | 1 - 2 | SligoSligo |
| 07 Jul 22 | Qualifier | Dinamo MinskDinamo Minsk | 1 - 1 | DečićDečić |
| 07 Jul 22 | Qualifier | Shkendija 79Shkendija 79 | 2 - 0 | Ararat YerevanArarat Yereva |
| 07 Jul 22 | Qualifier | HB TorshavnHB Torshavn | 1 - 0 | NewtownNewtown |
| 07 Jul 22 | Qualifier | FolaFola | 0 - 1 | Tre FioriTre Fiori |
| 07 Jul 22 | Qualifier | GjilaniGjilani | 1 - 0 | FK MetalurgsFK Metalurgs |
| 07 Jul 22 | Qualifier | Buducnost PodgoricaBuducnost Pod | 2 - 0 | LlapiLlapi |
| 07 Jul 22 | Qualifier | DAC 1904 Dunajská StredaDAC 1904 Duna | 2 - 1 | CliftonvilleCliftonville |
| 07 Jul 22 | Qualifier | Tre PenneTre Penne | 0 - 2 | Tuzla CityTuzla City |
| 12 Jul 22 | Qualifier | DritaDrita | 3 - 0 | Inter TurkuInter Turku |
| 14 Jul 22 | Qualifier | FK MetalurgsFK Metalurgs | 3 - 1 | GjilaniGjilani |
| 14 Jul 22 | Qualifier | Akademija PandevAkademija Pan | 1 - 2 | Lechia GdańskLechia Gdańsk |
| 14 Jul 22 | Qualifier | Europa FCEuropa FC | 1 - 2 | VikingurVikingur |
| 14 Jul 22 | Qualifier | Ararat YerevanArarat Yereva | 2 - 2 | Shkendija 79Shkendija 79 |
| 14 Jul 22 | Qualifier | Paide LinnameeskondPaide Linname | 1 - 2 | Dinamo TbilisiDinamo Tbilis |
| 14 Jul 22 | Qualifier | FC MilsamiFC Milsami | 2 - 0 | FK PanevėžysFK Panevėžys |
| 14 Jul 22 | Qualifier | Kauno ŽalgirisKauno Žalgiri | 0 - 0 | MFK RužomberokMFK Ružombero |
| 14 Jul 22 | Qualifier | Tuzla CityTuzla City | 6 - 0 | Tre PenneTre Penne |
| 14 Jul 22 | Qualifier | Petrocub HînceștiPetrocub Hînc | 1 - 0 | Floriana FCFloriana FC |
| 14 Jul 22 | Qualifier | SJK SeinajokiSJK Seinajoki | 4 - 2 | FC Flora TallinFC Flora Tall |
| 14 Jul 22 | Qualifier | Riga FCRiga FC | 2 - 0 | Derry CityDerry City |
| 14 Jul 22 | Qualifier | Dila GoriDila Gori | 0 - 0 | KuPS KuopioKuPS Kuopio |
| 14 Jul 22 | Qualifier | Atlètic d'EscaldesAtlètic d'Esc | 0 - 1 | Gżira UnitedGżira United |
| 14 Jul 22 | Qualifier | B36 TorshavnB36 Torshavn | 3 - 1 | Borac Banja LukaBorac Banja L |
| 14 Jul 22 | Qualifier | NewtownNewtown | 2 - 1 | HB TorshavnHB Torshavn |
| 14 Jul 22 | Qualifier | FC 03 DifferdangeFC 03 Differd | 1 - 2 | Olimpija LjubljanaOlimpija Ljub |
| 14 Jul 22 | Qualifier | Ħamrun SpartansĦamrun Sparta | 4 - 1 | AlashkertAlashkert |
| 14 Jul 22 | Qualifier | NŠ MuraNŠ Mura | 2 - 1 | Sfântul Gheorghe SuruceniSfântul Gheor |
| 14 Jul 22 | Qualifier | LlapiLlapi | 2 - 2 | Buducnost PodgoricaBuducnost Pod |
| 14 Jul 22 | Qualifier | SligoSligo | 0 - 1 | BalaBala |
| 14 Jul 22 | Qualifier | PartizaniPartizani | 0 - 1 | Saburtalo TbilisiSaburtalo Tbi |
| 14 Jul 22 | Qualifier | KR ReykjavikKR Reykjavik | 1 - 0 | Pogon SzczecinPogon Szczeci |
| 14 Jul 22 | Qualifier | DečićDečić | 1 - 2 | Dinamo MinskDinamo Minsk |
| 14 Jul 22 | Qualifier | Tre FioriTre Fiori | 3 - 1 | FolaFola |
| 14 Jul 22 | Qualifier | LarneLarne | 0 - 1 | St JosephsSt Josephs |
| 14 Jul 22 | Qualifier | Iskra DanilovgradIskra Danilov | 0 - 1 | LaciLaci |
| 14 Jul 22 | Qualifier | CliftonvilleCliftonville | 0 - 3 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| 14 Jul 22 | Qualifier | CrusadersCrusaders | 3 - 1 | Bruno-'s MagpiesBruno-'s Magp |
| 14 Jul 22 | Qualifier | BreidablikBreidablik | 4 - 1 | UE Santa ColomaUE Santa Colo |
| 19 Jul 22 | Qualifier | Hibernians FCHibernians FC | 3 - 2 | FC Levadia TallinnFC Levadia Ta |
| 19 Jul 22 | Qualifier | SK TiranaSK Tirana | 0 - 1 | ZrinjskiZrinjski |
| 19 Jul 22 | Qualifier | La FioritaLa Fiorita | 0 - 4 | BallkaniBallkani |
| 20 Jul 22 | Qualifier | Botev PlovdivBotev Plovdiv | 0 - 0 | Apoel NicosiaApoel Nicosia |
| 20 Jul 22 | Qualifier | VikingurVikingur | 0 - 2 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| 20 Jul 22 | Qualifier | SutjeskaSutjeska | 0 - 0 | KÍ KlaksvíkKÍ Klaksvík |
| 21 Jul 22 | Qualifier | Kyzylzhar SKKyzylzhar SK | 1 - 2 | OsijekOsijek |
| 21 Jul 22 | Qualifier | Kairat AlmatyKairat Almaty | 0 - 1 | Kisvárda FCKisvárda FC |
| 21 Jul 22 | Qualifier | FC TobolFC Tobol | 2 - 0 | Lincoln Red ImpsLincoln Red I |
| 21 Jul 22 | Qualifier | FK MetalurgsFK Metalurgs | 0 - 1 | Young BoysYoung Boys |
| 21 Jul 22 | Qualifier | Ararat-ArmeniaArarat-Armeni | 0 - 0 | Paide LinnameeskondPaide Linname |
| 21 Jul 22 | Qualifier | Valmieras FKValmieras FK | 1 - 2 | Shkendija 79Shkendija 79 |
| 21 Jul 22 | Qualifier | KuPS KuopioKuPS Kuopio | 2 - 2 | FC MilsamiFC Milsami |
| 21 Jul 22 | Qualifier | Makedonija GjPMakedonija Gj | 0 - 0 | CSKA SofiaCSKA Sofia |
| 21 Jul 22 | Qualifier | Zira FKZira FK | 0 - 3 | Maccabi Tel AvivMaccabi Tel A |
| 21 Jul 22 | Qualifier | MoldeMolde | 4 - 1 | ElfsborgElfsborg |
| 21 Jul 22 | Qualifier | KoperKoper | 0 - 1 | VaduzVaduz |
| 21 Jul 22 | Qualifier | Sparta PragueSparta Prague | 0 - 0 | VikingViking |
| 21 Jul 22 | Qualifier | Lech PoznanLech Poznan | 5 - 0 | Dinamo BatumiDinamo Batumi |
| 21 Jul 22 | Qualifier | Saburtalo TbilisiSaburtalo Tbi | 1 - 0 | Steaua BucurestiSteaua Bucure |
| 21 Jul 22 | Qualifier | SJK SeinajokiSJK Seinajoki | 0 - 1 | LillestroemLillestroem |
| 21 Jul 22 | Qualifier | Petrocub HînceștiPetrocub Hînc | 0 - 0 | LaciLaci |
| 21 Jul 22 | Qualifier | FK SuduvaFK Suduva | 0 - 1 | ViborgViborg |
| 21 Jul 22 | Qualifier | Pogon SzczecinPogon Szczeci | 1 - 1 | BrøndbyBrøndby |
| 21 Jul 22 | Qualifier | MFK RužomberokMFK Ružombero | 0 - 3 | Riga FCRiga FC |
| 21 Jul 22 | Qualifier | Videoton FC FehervarVideoton FC F | 4 - 1 | Gabala FKGabala FK |
| 21 Jul 22 | Qualifier | Levski SofiaLevski Sofia | 2 - 0 | PAOKPAOK |
| 21 Jul 22 | Qualifier | VorsklaVorskla | 3 - 2 | AIKAIK |
| 21 Jul 22 | Qualifier | AntwerpAntwerp | 0 - 0 | DritaDrita |
| 21 Jul 22 | Qualifier | Gżira UnitedGżira United | 2 - 2 | Radnički NišRadnički Niš |
| 21 Jul 22 | Qualifier | Rapid ViennaRapid Vienna | 0 - 0 | Lechia GdańskLechia Gdańsk |
| 21 Jul 22 | Qualifier | St JosephsSt Josephs | 0 - 4 | Slavia PragueSlavia Prague |
| 21 Jul 22 | Qualifier | B36 TorshavnB36 Torshavn | 1 - 0 | Tre FioriTre Fiori |
| 21 Jul 22 | Qualifier | FC BaselFC Basel | 2 - 0 | CrusadersCrusaders |
| 21 Jul 22 | Qualifier | Aris LimassolAris Limassol | 2 - 0 | Neftçi PFKNeftçi PFK |
| 21 Jul 22 | Qualifier | CFR Cluj-NapocaCFR Cluj-Napo | 3 - 0 | Inter Club d'EscaldesInter Club d' |
| 21 Jul 22 | Qualifier | Hapoel Beer ShevaHapoel Beer S | 2 - 1 | Dinamo MinskDinamo Minsk |
| 21 Jul 22 | Qualifier | Istanbul BasaksehirIstanbul Basa | 1 - 1 | Maccabi NetanyaMaccabi Netan |
| 21 Jul 22 | Qualifier | Racing FC Union LuxembourRacing FC Uni | 1 - 4 | CukarickiCukaricki |
| 21 Jul 22 | Qualifier | ArisAris | 5 - 1 | GomelGomel |
| 21 Jul 22 | Qualifier | Sepsi OSK Sfântu GheorgheSepsi OSK Sfâ | 3 - 1 | Olimpija LjubljanaOlimpija Ljub |
| 21 Jul 22 | Qualifier | GuimaraesGuimaraes | 3 - 0 | Puskás Akadémia FCPuskás Akadém |
| 21 Jul 22 | Qualifier  | RijekaRijeka | 1 - 2 | DjurgaardenDjurgaarden |
| 21 Jul 22 | Qualifier | FC Spartak TrnavaFC Spartak Tr | 4 - 1 | NewtownNewtown |
| 21 Jul 22 | Qualifier | Velez MostarVelez Mostar | 0 - 1 | Ħamrun SpartansĦamrun Sparta |
| 21 Jul 22 | Qualifier | AZ AlkmaarAZ Alkmaar | 1 - 0 | Tuzla CityTuzla City |
| 21 Jul 22 | Qualifier | St PatricksSt Patricks | 1 - 1 | NŠ MuraNŠ Mura |
| 21 Jul 22 | Qualifier | MotherwellMotherwell | 0 - 1 | SligoSligo |
| 21 Jul 22 | Qualifier | KF Vllaznia ShkodërKF Vllaznia S | 1 - 1 | Universitatea CraiovaUniversitatea |
| 21 Jul 22 | Qualifier | BATE BorisovBATE Borisov | 0 - 3 | KonyasporKonyaspor |
| 21 Jul 22 | Qualifier | Rakow CzestochowaRakow Czestoc | 5 - 0 | FC AstanaFC Astana |
| 21 Jul 22 | Qualifier | BreidablikBreidablik | 2 - 0 | Buducnost PodgoricaBuducnost Pod |
| 21 Jul 22 | Qualifier | Víkingur ReykjavikVíkingur Reyk | 2 - 0 | TNSTNS |
| 26 Jul 22 | Qualifier | Lincoln Red ImpsLincoln Red I | 0 - 1 | FC TobolFC Tobol |
| 26 Jul 22 | Qualifier | TNSTNS | 0 - 0 | Víkingur ReykjavikVíkingur Reyk |
| 26 Jul 22 | Qualifier | BallkaniBallkani | 6 - 0 | La FioritaLa Fiorita |
| 27 Jul 22 | Qualifier | Inter Club d'EscaldesInter Club d' | 1 - 1 | CFR Cluj-NapocaCFR Cluj-Napo |
| 27 Jul 22 | Qualifier | AIKAIK | 2 - 0 | VorsklaVorskla |
| 27 Jul 22 | Qualifier | GomelGomel | 1 - 2 | ArisAris |
| 27 Jul 22 | Qualifier | KÍ KlaksvíkKÍ Klaksvík | 1 - 0 | SutjeskaSutjeska |
| 28 Jul 22 | Qualifier | Kisvárda FCKisvárda FC | 1 - 0 | Kairat AlmatyKairat Almaty |
| 28 Jul 22 | Qualifier | FC AstanaFC Astana | 0 - 1 | Rakow CzestochowaRakow Czestoc |
| 28 Jul 22 | Qualifier | Gabala FKGabala FK | 2 - 1 | Videoton FC FehervarVideoton FC F |
| 28 Jul 22 | Qualifier | Paide LinnameeskondPaide Linname | 0 - 0 | Ararat-ArmeniaArarat-Armeni |
| 28 Jul 22 | Qualifier | FC MilsamiFC Milsami | 1 - 4 | KuPS KuopioKuPS Kuopio |
| 28 Jul 22 | Qualifier | Olimpija LjubljanaOlimpija Ljub | 2 - 0 | Sepsi OSK Sfântu GheorgheSepsi OSK Sfâ |
| 28 Jul 22 | Qualifier | Slavia PragueSlavia Prague | 7 - 0 | St JosephsSt Josephs |
| 28 Jul 22 | Qualifier | Maccabi NetanyaMaccabi Netan | 0 - 1 | Istanbul BasaksehirIstanbul Basa |
| 28 Jul 22 | Qualifier | ElfsborgElfsborg | 1 - 2 | MoldeMolde |
| 28 Jul 22 | Qualifier | Lechia GdańskLechia Gdańsk | 1 - 2 | Rapid ViennaRapid Vienna |
| 28 Jul 22 | Qualifier | CSKA SofiaCSKA Sofia | 4 - 0 | Makedonija GjPMakedonija Gj |
| 28 Jul 22 | Qualifier | Neftçi PFKNeftçi PFK | 3 - 0 | Aris LimassolAris Limassol |
| 28 Jul 22 | Qualifier | Apoel NicosiaApoel Nicosia | 2 - 0 | Botev PlovdivBotev Plovdiv |
| 28 Jul 22 | Qualifier | ViborgViborg | 1 - 0 | FK SuduvaFK Suduva |
| 28 Jul 22 | Qualifier | DjurgaardenDjurgaarden | 2 - 0 | RijekaRijeka |
| 28 Jul 22 | Qualifier | VikingViking | 2 - 1 | Sparta PragueSparta Prague |
| 28 Jul 22 | Qualifier | FC Levadia TallinnFC Levadia Ta | 1 - 1 | Hibernians FCHibernians FC |
| 28 Jul 22 | Qualifier | Dinamo BatumiDinamo Batumi | 1 - 1 | Lech PoznanLech Poznan |
| 28 Jul 22 | Qualifier | Radnički NišRadnički Niš | 3 - 3 | Gżira UnitedGżira United |
| 28 Jul 22 | Qualifier | LillestroemLillestroem | 5 - 2 | SJK SeinajokiSJK Seinajoki |
| 28 Jul 22 | Qualifier | Riga FCRiga FC | 2 - 1 | MFK RužomberokMFK Ružombero |
| 28 Jul 22 | Qualifier | NewtownNewtown | 1 - 2 | FC Spartak TrnavaFC Spartak Tr |
| 28 Jul 22 | Qualifier | Young BoysYoung Boys | 3 - 0 | FK MetalurgsFK Metalurgs |
| 28 Jul 22 | Qualifier | Maccabi Tel AvivMaccabi Tel A | 0 - 0 | Zira FKZira FK |
| 28 Jul 22 | Qualifier | Universitatea CraiovaUniversitatea | 3 - 0 | KF Vllaznia ShkodërKF Vllaznia S |
| 28 Jul 22 | Qualifier | PAOKPAOK | 1 - 1 | Levski SofiaLevski Sofia |
| 28 Jul 22 | Qualifier | Steaua BucurestiSteaua Bucure | 4 - 2 | Saburtalo TbilisiSaburtalo Tbi |
| 28 Jul 22 | Qualifier | KonyasporKonyaspor | 2 - 0 | BATE BorisovBATE Borisov |
| 28 Jul 22 | Qualifier | VaduzVaduz | 1 - 1 | KoperKoper |
| 28 Jul 22 | Qualifier | CukarickiCukaricki | 4 - 0 | Racing FC Union LuxembourRacing FC Uni |
| 28 Jul 22 | Qualifier | DritaDrita | 0 - 2 | AntwerpAntwerp |
| 28 Jul 22 | Qualifier | Ħamrun SpartansĦamrun Sparta | 1 - 0 | Velez MostarVelez Mostar |
| 28 Jul 22 | Qualifier | Dinamo MinskDinamo Minsk | 0 - 1 | Hapoel Beer ShevaHapoel Beer S |
| 28 Jul 22 | Qualifier | NŠ MuraNŠ Mura | 0 - 0 | St PatricksSt Patricks |
| 28 Jul 22 | Qualifier | BrøndbyBrøndby | 4 - 0 | Pogon SzczecinPogon Szczeci |
| 28 Jul 22 | Qualifier | SligoSligo | 2 - 0 | MotherwellMotherwell |
| 28 Jul 22 | Qualifier | LaciLaci | 1 - 4 | Petrocub HînceștiPetrocub Hînc |
| 28 Jul 22 | Qualifier | Shkendija 79Shkendija 79 | 3 - 1 | Valmieras FKValmieras FK |
| 28 Jul 22 | Qualifier | OsijekOsijek | 0 - 2 | Kyzylzhar SKKyzylzhar SK |
| 28 Jul 22 | Qualifier | Buducnost PodgoricaBuducnost Pod | 2 - 1 | BreidablikBreidablik |
| 28 Jul 22 | Qualifier | Tuzla CityTuzla City | 0 - 4 | AZ AlkmaarAZ Alkmaar |
| 28 Jul 22 | Qualifier | Tre FioriTre Fiori | 0 - 0 | B36 TorshavnB36 Torshavn |
| 28 Jul 22 | Qualifier | Puskás Akadémia FCPuskás Akadém | 0 - 0 | GuimaraesGuimaraes |
| 28 Jul 22 | Qualifier | ZrinjskiZrinjski | 3 - 2 | SK TiranaSK Tirana |
| 28 Jul 22 | Qualifier | DAC 1904 Dunajská StredaDAC 1904 Duna | 2 - 0 | VikingurVikingur |
| 28 Jul 22 | Qualifier | CrusadersCrusaders | 1 - 1 | FC BaselFC Basel |
| 03 Aug 22 | Qualifier | ViborgViborg | 3 - 0 | B36 TorshavnB36 Torshavn |
| 03 Aug 22 | Qualifier | Riga FCRiga FC | 1 - 1 | Gil VicenteGil Vicente |
| 03 Aug 22 | Qualifier | Wolfsberger ACWolfsberger A | 0 - 0 | Gżira UnitedGżira United |
| 03 Aug 22 | Qualifier | DAC 1904 Dunajská StredaDAC 1904 Duna | 0 - 1 | Steaua BucurestiSteaua Bucure |
| 04 Aug 22 | Qualifier | KuPS KuopioKuPS Kuopio | 0 - 2 | Young BoysYoung Boys |
| 04 Aug 22 | Qualifier | CSKA SofiaCSKA Sofia | 0 - 1 | St PatricksSt Patricks |
| 04 Aug 22 | Qualifier | Slavia PragueSlavia Prague | 2 - 0 | PanathinaikosPanathinaikos |
| 04 Aug 22 | Qualifier | Rīgas Futbola SkolaRīgas Futbola | 1 - 1 | Hibernians FCHibernians FC |
| 04 Aug 22 | Qualifier | FC Spartak TrnavaFC Spartak Tr | 0 - 2 | Rakow CzestochowaRakow Czestoc |
| 04 Aug 22 | Qualifier | Paide LinnameeskondPaide Linname | 0 - 2 | AnderlechtAnderlecht |
| 04 Aug 22 | Qualifier | Shakhter SoligorskShakhter Soli | 0 - 0 | CFR Cluj-NapocaCFR Cluj-Napo |
| 04 Aug 22 | Qualifier | AIKAIK | 1 - 1 | Shkendija 79Shkendija 79 |
| 04 Aug 22 | Qualifier | LillestroemLillestroem | 1 - 3 | AntwerpAntwerp |
| 04 Aug 22 | Qualifier | VikingViking | 5 - 1 | SligoSligo |
| 04 Aug 22 | Qualifier | Apoel NicosiaApoel Nicosia | 1 - 0 | Kyzylzhar SKKyzylzhar SK |
| 04 Aug 22 | Qualifier | MoldeMolde | 3 - 0 | Kisvárda FCKisvárda FC |
| 04 Aug 22 | Qualifier | Neftçi PFKNeftçi PFK | 2 - 1 | Rapid ViennaRapid Vienna |
| 04 Aug 22 | Qualifier | Maccabi Tel AvivMaccabi Tel A | 2 - 0 | ArisAris |
| 04 Aug 22 | Qualifier | Levski SofiaLevski Sofia | 0 - 1 | Ħamrun SpartansĦamrun Sparta |
| 04 Aug 22 | Qualifier | ZoryaZorya | 1 - 0 | Universitatea CraiovaUniversitatea |
| 04 Aug 22 | Qualifier | BallkaniBallkani | 3 - 2 | KÍ KlaksvíkKÍ Klaksvík |
| 04 Aug 22 | Qualifier | VaduzVaduz | 1 - 1 | KonyasporKonyaspor |
| 04 Aug 22 | Qualifier | Sepsi OSK Sfântu GheorgheSepsi OSK Sfâ | 1 - 3 | DjurgaardenDjurgaarden |
| 04 Aug 22 | Qualifier | LuganoLugano | 0 - 2 | Hapoel Beer ShevaHapoel Beer S |
| 04 Aug 22 | Qualifier | BrøndbyBrøndby | 1 - 0 | FC BaselFC Basel |
| 04 Aug 22 | Qualifier | BreidablikBreidablik | 1 - 3 | Istanbul BasaksehirIstanbul Basa |
| 04 Aug 22 | Qualifier | Víkingur ReykjavikVíkingur Reyk | 1 - 0 | Lech PoznanLech Poznan |
| 04 Aug 22 | Qualifier | Videoton FC FehervarVideoton FC F | 5 - 0 | Petrocub HînceștiPetrocub Hînc |
| 04 Aug 22 | Qualifier | ZrinjskiZrinjski | 1 - 0 | FC TobolFC Tobol |
| 04 Aug 22 | Qualifier | Hajduk SplitHajduk Split | 3 - 1 | GuimaraesGuimaraes |
| 04 Aug 22 | Qualifier | Dundee UnitedDundee United | 1 - 0 | AZ AlkmaarAZ Alkmaar |
| 09 Aug 22 | Qualifier | Gżira UnitedGżira United | 0 - 4 | Wolfsberger ACWolfsberger A |
| 09 Aug 22 | Qualifier | B36 TorshavnB36 Torshavn | 1 - 2 | ViborgViborg |
| 10 Aug 22 | Qualifier | GuimaraesGuimaraes | 1 - 0 | Hajduk SplitHajduk Split |
| 11 Aug 22 | Qualifier | Kyzylzhar SKKyzylzhar SK | 0 - 0 | Apoel NicosiaApoel Nicosia |
| 11 Aug 22 | Qualifier | FC TobolFC Tobol | 1 - 1 | ZrinjskiZrinjski |
| 11 Aug 22 | Qualifier | Rakow CzestochowaRakow Czestoc | 1 - 0 | FC Spartak TrnavaFC Spartak Tr |
| 11 Aug 22 | Qualifier | Petrocub HînceștiPetrocub Hînc | 1 - 2 | Videoton FC FehervarVideoton FC F |
| 11 Aug 22 | Qualifier | CFR Cluj-NapocaCFR Cluj-Napo | 1 - 0 | Shakhter SoligorskShakhter Soli |
| 11 Aug 22 | Qualifier | FC BaselFC Basel | 2 - 1 | BrøndbyBrøndby |
| 11 Aug 22 | Qualifier | KonyasporKonyaspor | 2 - 4 | VaduzVaduz |
| 11 Aug 22 | Qualifier | DjurgaardenDjurgaarden | 3 - 1 | Sepsi OSK Sfântu GheorgheSepsi OSK Sfâ |
| 11 Aug 22 | Qualifier | Hapoel Beer ShevaHapoel Beer S | 3 - 1 | LuganoLugano |
| 11 Aug 22 | Qualifier | FC TwenteFC Twente | 4 - 1 | CukarickiCukaricki |
| 11 Aug 22 | Qualifier | AntwerpAntwerp | 2 - 0 | LillestroemLillestroem |
| 11 Aug 22 | Qualifier | Steaua BucurestiSteaua Bucure | 1 - 0 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| 11 Aug 22 | Qualifier | Universitatea CraiovaUniversitatea | 3 - 0 | ZoryaZorya |
| 11 Aug 22 | Qualifier | PanathinaikosPanathinaikos | 1 - 1 | Slavia PragueSlavia Prague |
| 11 Aug 22 | Qualifier | Istanbul BasaksehirIstanbul Basa | 3 - 0 | BreidablikBreidablik |
| 11 Aug 22 | Qualifier | KÍ KlaksvíkKÍ Klaksvík | 2 - 1 | BallkaniBallkani |
| 11 Aug 22 | Qualifier | Young BoysYoung Boys | 3 - 0 | KuPS KuopioKuPS Kuopio |
| 11 Aug 22 | Qualifier | Shkendija 79Shkendija 79 | 1 - 1 | AIKAIK |
| 11 Aug 22 | Qualifier | SligoSligo | 1 - 0 | VikingViking |
| 11 Aug 22 | Qualifier | Kisvárda FCKisvárda FC | 2 - 1 | MoldeMolde |
| 11 Aug 22 | Qualifier | Ħamrun SpartansĦamrun Sparta | 1 - 2 | Levski SofiaLevski Sofia |
| 11 Aug 22 | Qualifier | ArisAris | 2 - 1 | Maccabi Tel AvivMaccabi Tel A |
| 11 Aug 22 | Qualifier | Hibernians FCHibernians FC | 1 - 3 | Rīgas Futbola SkolaRīgas Futbola |
| 11 Aug 22 | Qualifier | AnderlechtAnderlecht | 3 - 0 | Paide LinnameeskondPaide Linname |
| 11 Aug 22 | Qualifier | Rapid ViennaRapid Vienna | 2 - 0 | Neftçi PFKNeftçi PFK |
| 11 Aug 22 | Qualifier | Lech PoznanLech Poznan | 4 - 1 | Víkingur ReykjavikVíkingur Reyk |
| 11 Aug 22 | Qualifier | St PatricksSt Patricks | 0 - 2 | CSKA SofiaCSKA Sofia |
| 11 Aug 22 | Qualifier | AZ AlkmaarAZ Alkmaar | 7 - 0 | Dundee UnitedDundee United |
| 11 Aug 22 | Qualifier | Gil VicenteGil Vicente | 4 - 0 | Riga FCRiga FC |
| 17 Aug 22 | Qualifier | DjurgaardenDjurgaarden | 3 - 0 | Apoel NicosiaApoel Nicosia |
| 18 Aug 22 | Qualifier | CSKA SofiaCSKA Sofia | 1 - 0 | FC BaselFC Basel |
| 18 Aug 22 | Qualifier | Rakow CzestochowaRakow Czestoc | 2 - 1 | Slavia PragueSlavia Prague |
| 18 Aug 22 | Qualifier | Young BoysYoung Boys | 0 - 1 | AnderlechtAnderlecht |
| 18 Aug 22 | Qualifier | Rīgas Futbola SkolaRīgas Futbola | 2 - 2 | LinfieldLinfield |
| 18 Aug 22 | Qualifier | SlovackoSlovacko | 3 - 0 | AIKAIK |
| 18 Aug 22 | Qualifier | MoldeMolde | 0 - 1 | Wolfsberger ACWolfsberger A |
| 18 Aug 22 | Qualifier | Maccabi Tel AvivMaccabi Tel A | 1 - 0 | NiceNice |
| 18 Aug 22 | Qualifier | Universitatea CraiovaUniversitatea | 1 - 1 | Hapoel Beer ShevaHapoel Beer S |
| 18 Aug 22 | Qualifier | Istanbul BasaksehirIstanbul Basa | 1 - 1 | AntwerpAntwerp |
| 18 Aug 22 | Qualifier | ZrinjskiZrinjski | 1 - 0 | Slovan BratislavaSlovan Bratis |
| 18 Aug 22 | Qualifier | VaduzVaduz | 1 - 1 | Rapid ViennaRapid Vienna |
| 18 Aug 22 | Qualifier | Partizan BelgradePartizan Belg | 4 - 1 | Ħamrun SpartansĦamrun Sparta |
| 18 Aug 22 | Qualifier | NK MariborNK Maribor | 0 - 0 | CFR Cluj-NapocaCFR Cluj-Napo |
| 18 Aug 22 | Qualifier | Lech PoznanLech Poznan | 2 - 0 | F91 DudelangeF91 Dudelange |
| 18 Aug 22 | Qualifier | Steaua BucurestiSteaua Bucure | 1 - 2 | VikingViking |
| 18 Aug 22 | Qualifier | FC KolnFC Koln | 1 - 2 | Videoton FC FehervarVideoton FC F |
| 18 Aug 22 | Qualifier  | West HamWest Ham | 3 - 1 | ViborgViborg |
| 18 Aug 22 | Qualifier | VillarrealVillarreal | 4 - 2 | Hajduk SplitHajduk Split |
| 18 Aug 22 | Qualifier | FiorentinaFiorentina | 2 - 1 | FC TwenteFC Twente |
| 18 Aug 22 | Qualifier | AZ AlkmaarAZ Alkmaar | 4 - 0 | Gil VicenteGil Vicente |
| 18 Aug 22 | Qualifier | ShkupiShkupi | 1 - 2 | BallkaniBallkani |
| 23 Aug 22 | Qualifier | Apoel NicosiaApoel Nicosia | 3 - 2 | DjurgaardenDjurgaarden |
| 25 Aug 22 | Qualifier | Slavia PragueSlavia Prague | 2 - 0 | Rakow CzestochowaRakow Czestoc |
| 25 Aug 22 | Qualifier | ViborgViborg | 0 - 3 | West HamWest Ham |
| 25 Aug 22 | Qualifier | CFR Cluj-NapocaCFR Cluj-Napo | 1 - 0 | NK MariborNK Maribor |
| 25 Aug 22 | Qualifier | FC BaselFC Basel | 2 - 0 | CSKA SofiaCSKA Sofia |
| 25 Aug 22 | Qualifier | Hapoel Beer ShevaHapoel Beer S | 1 - 1 | Universitatea CraiovaUniversitatea |
| 25 Aug 22 | Qualifier | VikingViking | 1 - 3 | Steaua BucurestiSteaua Bucure |
| 25 Aug 22 | Qualifier | FC TwenteFC Twente | 0 - 0 | FiorentinaFiorentina |
| 25 Aug 22 | Qualifier | Videoton FC FehervarVideoton FC F | 0 - 3 | FC KolnFC Koln |
| 25 Aug 22 | Qualifier | AIKAIK | 0 - 1 | SlovackoSlovacko |
| 25 Aug 22 | Qualifier | Wolfsberger ACWolfsberger A | 0 - 4 | MoldeMolde |
| 25 Aug 22 | Qualifier | Slovan BratislavaSlovan Bratis | 2 - 1 | ZrinjskiZrinjski |
| 25 Aug 22 | Qualifier | Ħamrun SpartansĦamrun Sparta | 3 - 3 | Partizan BelgradePartizan Belg |
| 25 Aug 22 | Qualifier | AnderlechtAnderlecht | 0 - 1 | Young BoysYoung Boys |
| 25 Aug 22 | Qualifier | BallkaniBallkani | 1 - 0 | ShkupiShkupi |
| 25 Aug 22 | Qualifier | NiceNice | 2 - 0 | Maccabi Tel AvivMaccabi Tel A |
| 25 Aug 22 | Qualifier | F91 DudelangeF91 Dudelange | 1 - 1 | Lech PoznanLech Poznan |
| 25 Aug 22 | Qualifier | LinfieldLinfield | 1 - 1 | Rīgas Futbola SkolaRīgas Futbola |
| 25 Aug 22 | Qualifier | AntwerpAntwerp | 1 - 3 | Istanbul BasaksehirIstanbul Basa |
| 25 Aug 22 | Qualifier | Rapid ViennaRapid Vienna | 0 - 1 | VaduzVaduz |
| 25 Aug 22 | Qualifier | Gil VicenteGil Vicente | 1 - 2 | AZ AlkmaarAZ Alkmaar |
| 25 Aug 22 | Qualifier | Hajduk SplitHajduk Split | 0 - 2 | VillarrealVillarreal |
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