| 11 Aug 22 | r03  | Levski SofiaLevski Sofia | 1 - 2 | Ħamrun SpartansĦamrun Sparta |
| 06 Oct 22 | r03     | AnderlechtAnderlecht | 0 - 1 | West HamWest Ham |
| 06 Oct 22 | r03 | Silkeborg IFSilkeborg IF | 5 - 0 | Steaua BucurestiSteaua Bucure |
| 06 Oct 22 | r03 | Lech PoznanLech Poznan | 0 - 0 | Hapoel Beer ShevaHapoel Beer S |
| 06 Oct 22 | r03 | SlovackoSlovacko | 0 - 1 | NiceNice |
| 06 Oct 22 | r03 | SC Dnipro-1SC Dnipro-1 | 2 - 2 | VaduzVaduz |
| 06 Oct 22 | r03 | MoldeMolde | 3 - 0 | ShamrockShamrock |
| 06 Oct 22 | r03 | SivassporSivasspor | 3 - 4 | BallkaniBallkani |
| 06 Oct 22 | r03 | Pyunik YerevanPyunik Yereva | 2 - 0 | VMFD ZalgirisVMFD Zalgiris |
| 06 Oct 22 | r03 | Slavia PragueSlavia Prague | 0 - 1 | CFR Cluj-NapocaCFR Cluj-Napo |
| 06 Oct 22 | r03 | HeartsHearts | 0 - 3 | FiorentinaFiorentina |
| 06 Oct 22 | r03 | Rīgas Futbola SkolaRīgas Futbola | 0 - 0 | Istanbul BasaksehirIstanbul Basa |
| 06 Oct 22 | r03 | VillarrealVillarreal | 5 - 0 | Austria ViennaAustria Vienn |
| 06 Oct 22 | r03 | FC KolnFC Koln | 0 - 1 | Partizan BelgradePartizan Belg |
| 06 Oct 22 | r03 | AZ AlkmaarAZ Alkmaar | 3 - 2 | Apollon LimassolApollon Limas |
| 06 Oct 22 | r03 | GentGent | 0 - 1 | DjurgaardenDjurgaarden |
| 06 Oct 22 | r03 | FC BaselFC Basel | 0 - 2 | Slovan BratislavaSlovan Bratis |
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