| 09 Dec 21 | r06        | AlashkertAlashkert | 1 - 1 | Maccabi Tel AvivMaccabi Tel A |
| 09 Dec 21 | r06        | LASKLASK | 3 - 0 | HJK HelsinkiHJK Helsinki |
| 09 Dec 21 | r06        | GentGent | 1 - 0 | FC Flora TallinFC Flora Tall |
| 09 Dec 21 | r06        | Partizan BelgradePartizan Belg | 1 - 1 | Anorthosis FamagustaAnorthosis Fa |
| 09 Dec 21 | r06        | ZoryaZorya | 1 - 1 | Bodoe/GlimtBodoe/Glimt |
| 09 Dec 21 | r06        | CSKA SofiaCSKA Sofia | 2 - 3 | RomaRoma |
| 09 Dec 21 | r06        | AZ AlkmaarAZ Alkmaar | 1 - 0 | Randers FCRanders FC |
| 09 Dec 21 | r06        | CFR Cluj-NapocaCFR Cluj-Napo | 2 - 0 | JablonecJablonec |
| 09 Dec 21 | r06        | FeyenoordFeyenoord | 2 - 1 | Maccabi HaifaMaccabi Haifa |
| 09 Dec 21 | r06        | Union BerlinUnion Berlin | 1 - 1 | Slavia PragueSlavia Prague |
| 09 Dec 21 | r06        | PAOKPAOK | 2 - 0 | Lincoln Red ImpsLincoln Red I |
| 09 Dec 21 | r06        | FC CopenhagenFC Copenhagen | 2 - 0 | Slovan BratislavaSlovan Bratis |
| 09 Dec 21 | r06        | TottenhamTottenham | 0 - 3 | RennesRennes |
| 09 Dec 21 | r06        | VitesseVitesse | 3 - 1 | NŠ MuraNŠ Mura |
| 09 Dec 21 | r06        | FC BaselFC Basel | 3 - 0 | Qarabag FKQarabag FK |
| 09 Dec 21 | r06        | Omonia NicosiaOmonia Nicosi | 0 - 0 | Kairat AlmatyKairat Almaty |