| 06 Jul 21 | Qualifier   | Mosta FCMosta FC | 3 - 2 | FC Spartak TrnavaFC Spartak Tr |
| 06 Jul 21 | Qualifier | Mons CalpeMons Calpe | 1 - 1 | FC Santa ColomaFC Santa Colo |
| 06 Jul 21 | Qualifier | FK PodgoricaFK Podgorica | 1 - 0 | LaciLaci |
| 08 Jul 21 | Qualifier | NoahNoah | 1 - 0 | KuPS KuopioKuPS Kuopio |
| 08 Jul 21 | Qualifier | SileksSileks | 1 - 1 | Petrocub HînceștiPetrocub Hînc |
| 08 Jul 21 | Qualifier | FK MetalurgsFK Metalurgs | 1 - 1 | StrugaStruga |
| 08 Jul 21 | Qualifier  | Inter TurkuInter Turku | 1 - 1 | Puskás Akadémia FCPuskás Akadém |
| 08 Jul 21 | Qualifier | HonkaHonka | 0 - 0 | NSI RunavikNSI Runavik |
| 08 Jul 21 | Qualifier | FK Suduva FK Suduva | 2 - 1 | Valmieras FKValmieras FK |
| 08 Jul 21 | Qualifier | Sant JuliàSant Julià | 0 - 0 | Gżira UnitedGżira United |
| 08 Jul 21 | Qualifier | Rīgas Futbola SkolaRīgas Futbola | 2 - 3 | KÍ KlaksvíkKÍ Klaksvík |
| 08 Jul 21 | Qualifier | FC Levadia TallinnFC Levadia Ta | 3 - 1 | St JosephsSt Josephs |
| 08 Jul 21 | Qualifier | DundalkDundalk | 4 - 0 | NewtownNewtown |
| 08 Jul 21 | Qualifier | MSK ZilinaMSK Zilina | 5 - 1 | Dila GoriDila Gori |
| 08 Jul 21 | Qualifier | Racing FC Union LuxembourRacing FC Uni | 2 - 3 | BreidablikBreidablik |
| 08 Jul 21 | Qualifier | FC Milsami FC Milsami | 0 - 0 | FK SarajevoFK Sarajevo |
| 08 Jul 21 | Qualifier | GlentoranGlentoran | 1 - 1 | TNSTNS |
| 08 Jul 21 | Qualifier | BalaBala | 0 - 1 | LarneLarne |
| 08 Jul 21 | Qualifier | BirkirkaraBirkirkara | 1 - 0 | La FioritaLa Fiorita |
| 08 Jul 21 | Qualifier | ShkupiShkupi | 2 - 0 | LlapiLlapi |
| 08 Jul 21 | Qualifier | FH Hafnarfjordur FH Hafnarfjor | 1 - 0 | SligoSligo |
| 08 Jul 21 | Qualifier | Videoton FC FehervarVideoton FC F | 1 - 1 | Ararat YerevanArarat Yereva |
| 08 Jul 21 | Qualifier | Paide LinnameeskondPaide Linname | 1 - 2 | Slask WroclawSlask Wroclaw |
| 08 Jul 21 | Qualifier | DritaDrita | 2 - 1 | DečićDečić |
| 08 Jul 21 | Qualifier | PartizaniPartizani | 5 - 2 | Sfântul Gheorghe SuruceniSfântul Gheor |
| 08 Jul 21 | Qualifier | DomzaleDomzale | 1 - 0 | Swift HesperangeSwift Hespera |
| 08 Jul 21 | Qualifier | Europa FCEuropa FC | 0 - 0 | Kauno ŽalgirisKauno Žalgiri |
| 08 Jul 21 | Qualifier | Velez MostarVelez Mostar | 2 - 1 | ColeraineColeraine |
| 08 Jul 21 | Qualifier | SutjeskaSutjeska | 1 - 0 | GagraGagra |
| 08 Jul 21 | Qualifier | NK MariborNK Maribor | 1 - 0 | UrartuUrartu |
| 08 Jul 21 | Qualifier | Tre PenneTre Penne | 0 - 4 | Dinamo BatumiDinamo Batumi |
| 08 Jul 21 | Qualifier | Siroki BrijegSiroki Brijeg | 3 - 1 | KF Vllaznia ShkodërKF Vllaznia S |
| 08 Jul 21 | Qualifier | StjarnanStjarnan | 1 - 1 | BohemiansBohemians |
| 13 Jul 21 | Qualifier | NewtownNewtown | 0 - 1 | DundalkDundalk |
| 15 Jul 21 | Qualifier | Ararat YerevanArarat Yereva | 2 - 0 | Videoton FC FehervarVideoton FC F |
| 15 Jul 21 | Qualifier | StrugaStruga | 1 - 4 | FK MetalurgsFK Metalurgs |
| 15 Jul 21 | Qualifier | KuPS KuopioKuPS Kuopio | 5 - 0 | NoahNoah |
| 15 Jul 21 | Qualifier | Kauno ŽalgirisKauno Žalgiri | 2 - 0 | Europa FCEuropa FC |
| 15 Jul 21 | Qualifier | GagraGagra | 1 - 1 | SutjeskaSutjeska |
| 15 Jul 21 | Qualifier | Valmieras FKValmieras FK | 0 - 0 | FK Suduva FK Suduva |
| 15 Jul 21 | Qualifier | UrartuUrartu | 0 - 1 | NK MariborNK Maribor |
| 15 Jul 21 | Qualifier | Petrocub HînceștiPetrocub Hînc | 1 - 0 | SileksSileks |
| 15 Jul 21 | Qualifier | Dinamo BatumiDinamo Batumi | 3 - 0 | Tre PenneTre Penne |
| 15 Jul 21 | Qualifier | FC Santa ColomaFC Santa Colo | 4 - 0 | Mons CalpeMons Calpe |
| 15 Jul 21 | Qualifier | St JosephsSt Josephs | 1 - 1 | FC Levadia TallinnFC Levadia Ta |
| 15 Jul 21 | Qualifier | NSI RunavikNSI Runavik | 1 - 3 | HonkaHonka |
| 15 Jul 21 | Qualifier | Sfântul Gheorghe SuruceniSfântul Gheor | 2 - 3 | PartizaniPartizani |
| 15 Jul 21 | Qualifier | SligoSligo | 1 - 2 | FH Hafnarfjordur FH Hafnarfjor |
| 15 Jul 21 | Qualifier | Dila GoriDila Gori | 2 - 1 | MSK ZilinaMSK Zilina |
| 15 Jul 21 | Qualifier | TNSTNS | 2 - 0 | GlentoranGlentoran |
| 15 Jul 21 | Qualifier | Gżira UnitedGżira United | 1 - 1 | Sant JuliàSant Julià |
| 15 Jul 21 | Qualifier | Puskás Akadémia FCPuskás Akadém | 2 - 0 | Inter TurkuInter Turku |
| 15 Jul 21 | Qualifier | Swift HesperangeSwift Hespera | 1 - 1 | DomzaleDomzale |
| 15 Jul 21 | Qualifier | LaciLaci | 3 - 0 | FK PodgoricaFK Podgorica |
| 15 Jul 21 | Qualifier | LlapiLlapi | 1 - 1 | ShkupiShkupi |
| 15 Jul 21 | Qualifier | Slask WroclawSlask Wroclaw | 2 - 0 | Paide LinnameeskondPaide Linname |
| 15 Jul 21 | Qualifier | LarneLarne | 1 - 0 | BalaBala |
| 15 Jul 21 | Qualifier | DečićDečić | 0 - 1 | DritaDrita |
| 15 Jul 21 | Qualifier | BohemiansBohemians | 3 - 0 | StjarnanStjarnan |
| 15 Jul 21 | Qualifier | La FioritaLa Fiorita | 1 - 1 | BirkirkaraBirkirkara |
| 15 Jul 21 | Qualifier | FC Spartak TrnavaFC Spartak Tr | 2 - 0 | Mosta FCMosta FC |
| 15 Jul 21 | Qualifier | KÍ KlaksvíkKÍ Klaksvík | 2 - 4 | Rīgas Futbola SkolaRīgas Futbola |
| 15 Jul 21 | Qualifier | FK SarajevoFK Sarajevo | 0 - 1 | FC Milsami FC Milsami |
| 15 Jul 21 | Qualifier | BreidablikBreidablik | 2 - 0 | Racing FC Union LuxembourRacing FC Uni |
| 15 Jul 21 | Qualifier | KF Vllaznia ShkodërKF Vllaznia S | 3 - 0 | Siroki BrijegSiroki Brijeg |
| 15 Jul 21 | Qualifier | ColeraineColeraine | 1 - 2 | Velez MostarVelez Mostar |
| 20 Jul 21 | Qualifier | DomzaleDomzale | 1 - 1 | HonkaHonka |
| 20 Jul 21 | Qualifier | FC PrishtinaFC Prishtina | 4 - 1 | Connah's Quay NomadsConnah's Quay |
| 20 Jul 21 | Qualifier  | Kauno ŽalgirisKauno Žalgiri | 0 - 5 | TNSTNS |
| 20 Jul 21 | Qualifier | FolgoreFolgore | 1 - 3 | Hibernians FCHibernians FC |
| 21 Jul 21 | Qualifier | CukarickiCukaricki | 0 - 0 | Sumgayit FKSumgayit FK |
| 22 Jul 21 | Qualifier | FC AstanaFC Astana | 2 - 0 | ArisAris |
| 22 Jul 21 | Qualifier | Ararat YerevanArarat Yereva | 2 - 4 | Slask WroclawSlask Wroclaw |
| 22 Jul 21 | Qualifier | FK PanevėžysFK Panevėžys | 0 - 1 | VojvodinaVojvodina |
| 22 Jul 21 | Qualifier | Qarabag FKQarabag FK | 0 - 0 | FC AshdodFC Ashdod |
| 22 Jul 21 | Qualifier | MoldeMolde | 3 - 0 | ServetteServette |
| 22 Jul 21 | Qualifier | PFC SochiPFC Sochi | 3 - 0 | Keşla FKKeşla FK |
| 22 Jul 21 | Qualifier | Rīgas Futbola SkolaRīgas Futbola | 3 - 0 | Puskás Akadémia FCPuskás Akadém |
| 22 Jul 21 | Qualifier | Petrocub HînceștiPetrocub Hînc | 0 - 1 | SivassporSivasspor |
| 22 Jul 21 | Qualifier | KuPS KuopioKuPS Kuopio | 2 - 2 | VorsklaVorskla |
| 22 Jul 21 | Qualifier | Olimpija LjubljanaOlimpija Ljub | 1 - 0 | BirkirkaraBirkirkara |
| 22 Jul 21 | Qualifier | Austria ViennaAustria Vienn | 1 - 1 | BreidablikBreidablik |
| 22 Jul 21 | Qualifier | Dinamo TbilisiDinamo Tbilis | 1 - 2 | Maccabi HaifaMaccabi Haifa |
| 22 Jul 21 | Qualifier | F91 DudelangeF91 Dudelange | 0 - 1 | BohemiansBohemians |
| 22 Jul 21 | Qualifier | HammarbyHammarby | 3 - 1 | NK MariborNK Maribor |
| 22 Jul 21 | Qualifier | ElfsborgElfsborg | 4 - 0 | FC Milsami FC Milsami |
| 22 Jul 21 | Qualifier | Viktoria PlzenViktoria Plze | 2 - 1 | Dynamo BrestDynamo Brest |
| 22 Jul 21 | Qualifier | FC CopenhagenFC Copenhagen | 4 - 1 | Torpedo-BelAZ ZhodinoTorpedo-BelAZ |
| 22 Jul 21 | Qualifier | Lokomotiv Plovdiv Lokomotiv Plo | 1 - 0 | SlovackoSlovacko |
| 22 Jul 21 | Qualifier | KS Teuta KS Teuta | 0 - 2 | Inter Club d'EscaldesInter Club d' |
| 22 Jul 21 | Qualifier | Riga FCRiga FC | 2 - 0 | Shkendija 79Shkendija 79 |
| 22 Jul 21 | Qualifier | FK Suduva FK Suduva | 0 - 0 | Rakow CzestochowaRakow Czestoc |
| 22 Jul 21 | Qualifier | Gżira UnitedGżira United | 0 - 2 | RijekaRijeka |
| 22 Jul 21 | Qualifier | Dinamo BatumiDinamo Batumi | 0 - 1 | BATE BorisovBATE Borisov |
| 22 Jul 21 | Qualifier | Apollon LimassolApollon Limas | 1 - 3 | MSK ZilinaMSK Zilina |
| 22 Jul 21 | Qualifier | CSKA SofiaCSKA Sofia | 0 - 0 | FK MetalurgsFK Metalurgs |
| 22 Jul 21 | Qualifier | LaciLaci | 1 - 0 | Universitatea CraiovaUniversitatea |
| 22 Jul 21 | Qualifier | AEL LimassolAEL Limassol | 1 - 0 | KF Vllaznia ShkodërKF Vllaznia S |
| 22 Jul 21 | Qualifier | FC Spartak TrnavaFC Spartak Tr | 0 - 0 | Sepsi OSK Sfântu GheorgheSepsi OSK Sfâ |
| 22 Jul 21 | Qualifier | Arda KardzhaliArda Kardzhal | 0 - 2 | Hapoel Beer ShevaHapoel Beer S |
| 22 Jul 21 | Qualifier | Partizan BelgradePartizan Belg | 1 - 0 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| 22 Jul 21 | Qualifier | HB TorshavnHB Torshavn | 4 - 0 | Buducnost PodgoricaBuducnost Pod |
| 22 Jul 21 | Qualifier | ShkupiShkupi | 0 - 3 | Santa ClaraSanta Clara |
| 22 Jul 21 | Qualifier | FC BaselFC Basel | 3 - 0 | PartizaniPartizani |
| 22 Jul 21 | Qualifier | Steaua BucurestiSteaua Bucure | 1 - 0 | Shakhter KaragandaShakhter Kara |
| 22 Jul 21 | Qualifier | GentGent | 4 - 0 | VaalerengaVaalerenga |
| 22 Jul 21 | Qualifier | SutjeskaSutjeska | 0 - 0 | Maccabi Tel AvivMaccabi Tel A |
| 22 Jul 21 | Qualifier | LarneLarne | 2 - 1 | AGF AarhusAGF Aarhus |
| 22 Jul 21 | Qualifier  | Velez MostarVelez Mostar | 2 - 1 | AEKAEK |
| 22 Jul 21 | Qualifier | AberdeenAberdeen | 5 - 1 | HackenHacken |
| 22 Jul 21 | Qualifier | LinfieldLinfield | 4 - 0 | Borac Banja LukaBorac Banja L |
| 22 Jul 21 | Qualifier | HibernianHibernian | 3 - 0 | FC Santa ColomaFC Santa Colo |
| 22 Jul 21 | Qualifier | Pogon SzczecinPogon Szczeci | 0 - 0 | OsijekOsijek |
| 22 Jul 21 | Qualifier | Újpest FCÚjpest FC | 2 - 1 | VaduzVaduz |
| 22 Jul 21 | Qualifier | Hajduk SplitHajduk Split | 2 - 0 | FC TobolFC Tobol |
| 22 Jul 21 | Qualifier | FH Hafnarfjordur FH Hafnarfjor | 0 - 2 | RosenborgRosenborg |
| 22 Jul 21 | Qualifier | DundalkDundalk | 2 - 2 | FC Levadia TallinnFC Levadia Ta |
| 22 Jul 21 | Qualifier | ValurValur | 0 - 3 | Bodoe/GlimtBodoe/Glimt |
| 22 Jul 21 | Qualifier | DritaDrita | 0 - 0 | FeyenoordFeyenoord |
| 22 Jul 21 | Qualifier | Shakhter SoligorskShakhter Soli | 1 - 2 | FolaFola |
| 27 Jul 21 | Qualifier | Inter Club d'EscaldesInter Club d' | 0 - 3 | KS Teuta KS Teuta |
| 27 Jul 21 | Qualifier | Buducnost PodgoricaBuducnost Pod | 0 - 2 | HB TorshavnHB Torshavn |
| 27 Jul 21 | Qualifier | Hibernians FCHibernians FC | 4 - 2 | FolgoreFolgore |
| 29 Jul 21 | Qualifier | Shakhter KaragandaShakhter Kara | 2 - 1 | Steaua BucurestiSteaua Bucure |
| 29 Jul 21 | Qualifier | FK MetalurgsFK Metalurgs | 0 - 0 | CSKA SofiaCSKA Sofia |
| 29 Jul 21 | Qualifier | FC TobolFC Tobol | 4 - 1 | Hajduk SplitHajduk Split |
| 29 Jul 21 | Qualifier | Keşla FKKeşla FK | 2 - 4 | PFC SochiPFC Sochi |
| 29 Jul 21 | Qualifier | Dynamo BrestDynamo Brest | 1 - 2 | Viktoria PlzenViktoria Plze |
| 29 Jul 21 | Qualifier | Sumgayit FKSumgayit FK | 0 - 2 | CukarickiCukaricki |
| 29 Jul 21 | Qualifier | VaduzVaduz | 1 - 3 | Újpest FCÚjpest FC |
| 29 Jul 21 | Qualifier | Bodoe/GlimtBodoe/Glimt | 3 - 0 | ValurValur |
| 29 Jul 21 | Qualifier | VorsklaVorskla | 2 - 3 | KuPS KuopioKuPS Kuopio |
| 29 Jul 21 | Qualifier | HonkaHonka | 0 - 1 | DomzaleDomzale |
| 29 Jul 21 | Qualifier | BirkirkaraBirkirkara | 1 - 0 | Olimpija LjubljanaOlimpija Ljub |
| 29 Jul 21 | Qualifier | HackenHacken | 2 - 0 | AberdeenAberdeen |
| 29 Jul 21 | Qualifier | FC Santa ColomaFC Santa Colo | 1 - 2 | HibernianHibernian |
| 29 Jul 21 | Qualifier | FC Levadia TallinnFC Levadia Ta | 1 - 2 | DundalkDundalk |
| 29 Jul 21 | Qualifier | Sepsi OSK Sfântu GheorgheSepsi OSK Sfâ | 1 - 1 | FC Spartak TrnavaFC Spartak Tr |
| 29 Jul 21 | Qualifier | MSK ZilinaMSK Zilina | 2 - 2 | Apollon LimassolApollon Limas |
| 29 Jul 21 | Qualifier | FC AshdodFC Ashdod | 0 - 1 | Qarabag FKQarabag FK |
| 29 Jul 21 | Qualifier | Torpedo-BelAZ ZhodinoTorpedo-BelAZ | 0 - 5 | FC CopenhagenFC Copenhagen |
| 29 Jul 21 | Qualifier | VaalerengaVaalerenga | 2 - 0 | GentGent |
| 29 Jul 21 | Qualifier | Hapoel Beer ShevaHapoel Beer S | 4 - 0 | Arda KardzhaliArda Kardzhal |
| 29 Jul 21 | Qualifier | SlovackoSlovacko | 1 - 0 | Lokomotiv Plovdiv Lokomotiv Plo |
| 29 Jul 21 | Qualifier | SivassporSivasspor | 1 - 0 | Petrocub HînceștiPetrocub Hînc |
| 29 Jul 21 | Qualifier | Maccabi HaifaMaccabi Haifa | 5 - 1 | Dinamo TbilisiDinamo Tbilis |
| 29 Jul 21 | Qualifier | RosenborgRosenborg | 4 - 1 | FH Hafnarfjordur FH Hafnarfjor |
| 29 Jul 21 | Qualifier | Rakow CzestochowaRakow Czestoc | 0 - 0 | FK Suduva FK Suduva |
| 29 Jul 21 | Qualifier | BATE BorisovBATE Borisov | 1 - 4 | Dinamo BatumiDinamo Batumi |
| 29 Jul 21 | Qualifier | FC Milsami FC Milsami | 0 - 5 | ElfsborgElfsborg |
| 29 Jul 21 | Qualifier | AGF AarhusAGF Aarhus | 1 - 1 | LarneLarne |
| 29 Jul 21 | Qualifier | Slask WroclawSlask Wroclaw | 3 - 3 | Ararat YerevanArarat Yereva |
| 29 Jul 21 | Qualifier | TNSTNS | 5 - 1 | Kauno ŽalgirisKauno Žalgiri |
| 29 Jul 21 | Qualifier | FolaFola | 1 - 0 | Shakhter SoligorskShakhter Soli |
| 29 Jul 21 | Qualifier | Maccabi Tel AvivMaccabi Tel A | 3 - 1 | SutjeskaSutjeska |
| 29 Jul 21 | Qualifier | BreidablikBreidablik | 2 - 1 | Austria ViennaAustria Vienn |
| 29 Jul 21 | Qualifier | VojvodinaVojvodina | 1 - 0 | FK PanevėžysFK Panevėžys |
| 29 Jul 21 | Qualifier | Shkendija 79Shkendija 79 | 0 - 1 | Riga FCRiga FC |
| 29 Jul 21 | Qualifier | Borac Banja LukaBorac Banja L | 0 - 0 | LinfieldLinfield |
| 29 Jul 21 | Qualifier | Connah's Quay NomadsConnah's Quay | 4 - 2 | FC PrishtinaFC Prishtina |
| 29 Jul 21 | Qualifier | Puskás Akadémia FCPuskás Akadém | 0 - 2 | Rīgas Futbola SkolaRīgas Futbola |
| 29 Jul 21 | Qualifier | PartizaniPartizani | 0 - 2 | FC BaselFC Basel |
| 29 Jul 21 | Qualifier | RijekaRijeka | 1 - 0 | Gżira UnitedGżira United |
| 29 Jul 21 | Qualifier | AEKAEK | 1 - 0 | Velez MostarVelez Mostar |
| 29 Jul 21 | Qualifier | FeyenoordFeyenoord | 3 - 2 | DritaDrita |
| 29 Jul 21 | Qualifier | ServetteServette | 2 - 0 | MoldeMolde |
| 29 Jul 21 | Qualifier | ArisAris | 2 - 1 | FC AstanaFC Astana |
| 29 Jul 21 | Qualifier | Universitatea CraiovaUniversitatea | 0 - 0 | LaciLaci |
| 29 Jul 21 | Qualifier | DAC 1904 Dunajská StredaDAC 1904 Duna | 0 - 2 | Partizan BelgradePartizan Belg |
| 29 Jul 21 | Qualifier | NK MariborNK Maribor | 0 - 1 | HammarbyHammarby |
| 29 Jul 21 | Qualifier | BohemiansBohemians | 3 - 0 | F91 DudelangeF91 Dudelange |
| 29 Jul 21 | Qualifier | OsijekOsijek | 1 - 0 | Pogon SzczecinPogon Szczeci |
| 29 Jul 21 | Qualifier | KF Vllaznia ShkodërKF Vllaznia S | 0 - 1 | AEL LimassolAEL Limassol |
| 29 Jul 21 | Qualifier | Santa ClaraSanta Clara | 2 - 0 | ShkupiShkupi |
| 03 Aug 21 | Qualifier | LinfieldLinfield | 1 - 2 | FolaFola |
| 03 Aug 21 | Qualifier | BohemiansBohemians | 2 - 1 | PAOKPAOK |
| 05 Aug 21 | Qualifier | KuPS KuopioKuPS Kuopio | 1 - 1 | FC AstanaFC Astana |
| 05 Aug 21 | Qualifier | CSKA SofiaCSKA Sofia | 4 - 2 | OsijekOsijek |
| 05 Aug 21 | Qualifier | Lokomotiv Plovdiv Lokomotiv Plo | 1 - 1 | FC CopenhagenFC Copenhagen |
| 05 Aug 21 | Qualifier | PFC SochiPFC Sochi | 1 - 1 | Partizan BelgradePartizan Belg |
| 05 Aug 21 | Qualifier | FC TobolFC Tobol | 0 - 1 | MSK ZilinaMSK Zilina |
| 05 Aug 21 | Qualifier | ElfsborgElfsborg | 1 - 1 | Velez MostarVelez Mostar |
| 05 Aug 21 | Qualifier | Dinamo BatumiDinamo Batumi | 1 - 2 | SivassporSivasspor |
| 05 Aug 21 | Qualifier | AEL LimassolAEL Limassol | 1 - 1 | Qarabag FKQarabag FK |
| 05 Aug 21 | Qualifier | Slask WroclawSlask Wroclaw | 2 - 1 | Hapoel Beer ShevaHapoel Beer S |
| 05 Aug 21 | Qualifier | RosenborgRosenborg | 6 - 1 | DomzaleDomzale |
| 05 Aug 21 | Qualifier | Riga FCRiga FC | 0 - 1 | Hibernians FCHibernians FC |
| 05 Aug 21 | Qualifier | LaciLaci | 0 - 3 | AnderlechtAnderlecht |
| 05 Aug 21 | Qualifier | Maccabi HaifaMaccabi Haifa | 7 - 2 | HB TorshavnHB Torshavn |
| 05 Aug 21 | Qualifier | VojvodinaVojvodina | 0 - 1 | LASKLASK |
| 05 Aug 21 | Qualifier | VitesseVitesse | 2 - 2 | DundalkDundalk |
| 05 Aug 21 | Qualifier | TrabzonsporTrabzonspor | 3 - 3 | MoldeMolde |
| 05 Aug 21 | Qualifier | FC PrishtinaFC Prishtina | 2 - 1 | Bodoe/GlimtBodoe/Glimt |
| 05 Aug 21 | Qualifier | CukarickiCukaricki | 3 - 1 | HammarbyHammarby |
| 05 Aug 21 | Qualifier | F.C. Paços de FerreiraF.C. Paços de | 4 - 0 | LarneLarne |
| 05 Aug 21 | Qualifier | FC Kolos KovalivkaFC Kolos Kova | 0 - 0 | Shakhter KaragandaShakhter Kara |
| 05 Aug 21 | Qualifier | FC Spartak TrnavaFC Spartak Tr | 0 - 0 | Maccabi Tel AvivMaccabi Tel A |
| 05 Aug 21 | Qualifier | Lucerne Lucerne | 0 - 3 | FeyenoordFeyenoord |
| 05 Aug 21 | Qualifier | GentGent | 2 - 2 | Rīgas Futbola SkolaRīgas Futbola |
| 05 Aug 21 | Qualifier | HibernianHibernian | 1 - 1 | RijekaRijeka |
| 05 Aug 21 | Qualifier | TNSTNS | 4 - 2 | Viktoria PlzenViktoria Plze |
| 05 Aug 21 | Qualifier | ShamrockShamrock | 1 - 0 | KS Teuta KS Teuta |
| 05 Aug 21 | Qualifier | BreidablikBreidablik | 2 - 3 | AberdeenAberdeen |
| 05 Aug 21 | Qualifier | Újpest FCÚjpest FC | 1 - 2 | FC BaselFC Basel |
| 05 Aug 21 | Qualifier | Rakow CzestochowaRakow Czestoc | 0 - 0 | FK Rubin KazanFK Rubin Kaza |
| 05 Aug 21 | Qualifier | Santa ClaraSanta Clara | 2 - 0 | Olimpija LjubljanaOlimpija Ljub |
| 10 Aug 21 | Qualifier | Shakhter KaragandaShakhter Kara | 0 - 0 | FC Kolos KovalivkaFC Kolos Kova |
| 10 Aug 21 | Qualifier | DomzaleDomzale | 1 - 2 | RosenborgRosenborg |
| 12 Aug 21 | Qualifier | FC AstanaFC Astana | 3 - 4 | KuPS KuopioKuPS Kuopio |
| 12 Aug 21 | Qualifier | Bodoe/GlimtBodoe/Glimt | 2 - 0 | FC PrishtinaFC Prishtina |
| 12 Aug 21 | Qualifier | Qarabag FKQarabag FK | 1 - 0 | AEL LimassolAEL Limassol |
| 12 Aug 21 | Qualifier | MoldeMolde | 1 - 1 | TrabzonsporTrabzonspor |
| 12 Aug 21 | Qualifier | FK Rubin KazanFK Rubin Kaza | 0 - 1 | Rakow CzestochowaRakow Czestoc |
| 12 Aug 21 | Qualifier | HammarbyHammarby | 5 - 1 | CukarickiCukaricki |
| 12 Aug 21 | Qualifier | MSK ZilinaMSK Zilina | 5 - 0 | FC TobolFC Tobol |
| 12 Aug 21 | Qualifier | Rīgas Futbola SkolaRīgas Futbola | 0 - 1 | GentGent |
| 12 Aug 21 | Qualifier | Olimpija LjubljanaOlimpija Ljub | 0 - 1 | Santa ClaraSanta Clara |
| 12 Aug 21 | Qualifier | Hapoel Beer ShevaHapoel Beer S | 4 - 0 | Slask WroclawSlask Wroclaw |
| 12 Aug 21 | Qualifier | Viktoria PlzenViktoria Plze | 3 - 1 | TNSTNS |
| 12 Aug 21 | Qualifier | PAOKPAOK | 2 - 0 | BohemiansBohemians |
| 12 Aug 21 | Qualifier | FolaFola | 2 - 1 | LinfieldLinfield |
| 12 Aug 21 | Qualifier | FC BaselFC Basel | 4 - 0 | Újpest FCÚjpest FC |
| 12 Aug 21 | Qualifier | Maccabi Tel AvivMaccabi Tel A | 1 - 0 | FC Spartak TrnavaFC Spartak Tr |
| 12 Aug 21 | Qualifier | KS Teuta KS Teuta | 0 - 2 | ShamrockShamrock |
| 12 Aug 21 | Qualifier | SivassporSivasspor | 1 - 1 | Dinamo BatumiDinamo Batumi |
| 12 Aug 21 | Qualifier | FC CopenhagenFC Copenhagen | 4 - 2 | Lokomotiv Plovdiv Lokomotiv Plo |
| 12 Aug 21 | Qualifier | Partizan BelgradePartizan Belg | 2 - 2 | PFC SochiPFC Sochi |
| 12 Aug 21 | Qualifier | Velez MostarVelez Mostar | 1 - 4 | ElfsborgElfsborg |
| 12 Aug 21 | Qualifier | RijekaRijeka | 4 - 1 | HibernianHibernian |
| 12 Aug 21 | Qualifier | FeyenoordFeyenoord | 3 - 0 | Lucerne Lucerne |
| 12 Aug 21 | Qualifier | Hibernians FCHibernians FC | 1 - 4 | Riga FCRiga FC |
| 12 Aug 21 | Qualifier | AnderlechtAnderlecht | 2 - 1 | LaciLaci |
| 12 Aug 21 | Qualifier | LarneLarne | 1 - 0 | F.C. Paços de FerreiraF.C. Paços de |
| 12 Aug 21 | Qualifier | AberdeenAberdeen | 2 - 1 | BreidablikBreidablik |
| 12 Aug 21 | Qualifier | HB TorshavnHB Torshavn | 1 - 0 | Maccabi HaifaMaccabi Haifa |
| 12 Aug 21 | Qualifier | DundalkDundalk | 1 - 2 | VitesseVitesse |
| 12 Aug 21 | Qualifier | LASKLASK | 6 - 1 | VojvodinaVojvodina |
| 12 Aug 21 | Qualifier | OsijekOsijek | 1 - 1 | CSKA SofiaCSKA Sofia |
| 19 Aug 21 | Qualifier | Shakhter KaragandaShakhter Kara | 1 - 2 | Maccabi Tel AvivMaccabi Tel A |
| 19 Aug 21 | Qualifier | KuPS KuopioKuPS Kuopio | 0 - 4 | Union BerlinUnion Berlin |
| 19 Aug 21 | Qualifier | FC Flora TallinFC Flora Tall | 4 - 2 | ShamrockShamrock |
| 19 Aug 21 | Qualifier | Qarabag FKQarabag FK | 1 - 0 | AberdeenAberdeen |
| 19 Aug 21 | Qualifier | Rakow CzestochowaRakow Czestoc | 1 - 0 | GentGent |
| 19 Aug 21 | Qualifier | VMFD ZalgirisVMFD Zalgiris | 2 - 2 | Bodoe/GlimtBodoe/Glimt |
| 19 Aug 21 | Qualifier | Neftçi PFKNeftçi PFK | 3 - 3 | Maccabi HaifaMaccabi Haifa |
| 19 Aug 21 | Qualifier | Riga FCRiga FC | 1 - 1 | Lincoln Red ImpsLincoln Red I |
| 19 Aug 21 | Qualifier | Viktoria PlzenViktoria Plze | 2 - 0 | CSKA SofiaCSKA Sofia |
| 19 Aug 21 | Qualifier | Hapoel Beer ShevaHapoel Beer S | 0 - 0 | Anorthosis FamagustaAnorthosis Fa |
| 19 Aug 21 | Qualifier | LASKLASK | 1 - 1 | St JohnstoneSt Johnstone |
| 19 Aug 21 | Qualifier | FolaFola | 1 - 4 | Kairat AlmatyKairat Almaty |
| 19 Aug 21 | Qualifier | FC BaselFC Basel | 3 - 1 | HammarbyHammarby |
| 19 Aug 21 | Qualifier | TrabzonsporTrabzonspor | 1 - 2 | RomaRoma |
| 19 Aug 21 | Qualifier | RennesRennes | 2 - 0 | RosenborgRosenborg |
| 19 Aug 21 | Qualifier | AnderlechtAnderlecht | 3 - 3 | VitesseVitesse |
| 19 Aug 21 | Qualifier | PAOKPAOK | 1 - 1 | RijekaRijeka |
| 19 Aug 21 | Qualifier | FeyenoordFeyenoord | 5 - 0 | ElfsborgElfsborg |
| 19 Aug 21 | Qualifier | SivassporSivasspor | 1 - 2 | FC CopenhagenFC Copenhagen |
| 19 Aug 21 | Qualifier | JablonecJablonec | 5 - 1 | MSK ZilinaMSK Zilina |
| 19 Aug 21 | Qualifier | F.C. Paços de FerreiraF.C. Paços de | 1 - 0 | TottenhamTottenham |
| 19 Aug 21 | Qualifier | Santa ClaraSanta Clara | 2 - 1 | Partizan BelgradePartizan Belg |
| 26 Aug 21 | Qualifier | Kairat AlmatyKairat Almaty | 3 - 1 | FolaFola |
| 26 Aug 21 | Qualifier | Bodoe/GlimtBodoe/Glimt | 1 - 0 | VMFD ZalgirisVMFD Zalgiris |
| 26 Aug 21 | Qualifier | Lincoln Red ImpsLincoln Red I | 3 - 1 | Riga FCRiga FC |
| 26 Aug 21 | Qualifier | CSKA SofiaCSKA Sofia | 3 - 0 | Viktoria PlzenViktoria Plze |
| 26 Aug 21 | Qualifier | MSK ZilinaMSK Zilina | 0 - 3 | JablonecJablonec |
| 26 Aug 21 | Qualifier | RosenborgRosenborg | 1 - 3 | RennesRennes |
| 26 Aug 21 | Qualifier | Maccabi HaifaMaccabi Haifa | 4 - 0 | Neftçi PFKNeftçi PFK |
| 26 Aug 21 | Qualifier | HammarbyHammarby | 3 - 1 | FC BaselFC Basel |
| 26 Aug 21 | Qualifier | VitesseVitesse | 2 - 1 | AnderlechtAnderlecht |
| 26 Aug 21 | Qualifier | ElfsborgElfsborg | 3 - 1 | FeyenoordFeyenoord |
| 26 Aug 21 | Qualifier | FC CopenhagenFC Copenhagen | 5 - 0 | SivassporSivasspor |
| 26 Aug 21 | Qualifier | RomaRoma | 3 - 0 | TrabzonsporTrabzonspor |
| 26 Aug 21 | Qualifier | Anorthosis FamagustaAnorthosis Fa | 3 - 1 | Hapoel Beer ShevaHapoel Beer S |
| 26 Aug 21 | Qualifier | Maccabi Tel AvivMaccabi Tel A | 2 - 0 | Shakhter KaragandaShakhter Kara |
| 26 Aug 21 | Qualifier | St JohnstoneSt Johnstone | 0 - 2 | LASKLASK |
| 26 Aug 21 | Qualifier | RijekaRijeka | 0 - 2 | PAOKPAOK |
| 26 Aug 21 | Qualifier | GentGent | 3 - 0 | Rakow CzestochowaRakow Czestoc |
| 26 Aug 21 | Qualifier | Partizan BelgradePartizan Belg | 2 - 0 | Santa ClaraSanta Clara |
| 26 Aug 21 | Qualifier | Union BerlinUnion Berlin | 0 - 0 | KuPS KuopioKuPS Kuopio |
| 26 Aug 21 | Qualifier | ShamrockShamrock | 0 - 1 | FC Flora TallinFC Flora Tall |
| 26 Aug 21 | Qualifier | AberdeenAberdeen | 1 - 3 | Qarabag FKQarabag FK |
| 26 Aug 21 | Qualifier | TottenhamTottenham | 3 - 0 | F.C. Paços de FerreiraF.C. Paços de |
| |
| 14 Sep 21 | r01 | Maccabi HaifaMaccabi Haifa | 0 - 0 | FeyenoordFeyenoord |
| 14 Sep 21 | r01 | Maccabi Tel AvivMaccabi Tel A | 4 - 1 | AlashkertAlashkert |
| 16 Sep 21 | r01 | Kairat AlmatyKairat Almaty | 0 - 0 | Omonia NicosiaOmonia Nicosi |
| 16 Sep 21 | r01 | Slovan BratislavaSlovan Bratis | 1 - 3 | FC CopenhagenFC Copenhagen |
| 16 Sep 21 | r01 | HJK HelsinkiHJK Helsinki | 0 - 2 | LASKLASK |
| 16 Sep 21 | r01 | Slavia PragueSlavia Prague | 3 - 1 | Union BerlinUnion Berlin |
| 16 Sep 21 | r01 | Lincoln Red ImpsLincoln Red I | 0 - 2 | PAOKPAOK |
| 16 Sep 21 | r01 | RennesRennes | 2 - 2 | TottenhamTottenham |
| 16 Sep 21 | r01 | NŠ MuraNŠ Mura | 0 - 2 | VitesseVitesse |
| 16 Sep 21 | r01 | Qarabag FKQarabag FK | 0 - 0 | FC BaselFC Basel |
| 16 Sep 21 | r01 | FC Flora TallinFC Flora Tall | 0 - 1 | GentGent |
| 16 Sep 21 | r01 | Anorthosis FamagustaAnorthosis Fa | 0 - 2 | Partizan BelgradePartizan Belg |
| 16 Sep 21 | r01 | RomaRoma | 5 - 1 | CSKA SofiaCSKA Sofia |
| 16 Sep 21 | r01 | Bodoe/GlimtBodoe/Glimt | 3 - 1 | ZoryaZorya |
| 16 Sep 21 | r01 | JablonecJablonec | 1 - 0 | CFR Cluj-NapocaCFR Cluj-Napo |
| 16 Sep 21 | r01 | Randers FCRanders FC | 2 - 2 | AZ AlkmaarAZ Alkmaar |
| |
| 30 Sep 21 | r02 | Partizan BelgradePartizan Belg | 2 - 0 | FC Flora TallinFC Flora Tall |
| 30 Sep 21 | r02 | CSKA SofiaCSKA Sofia | 0 - 0 | Bodoe/GlimtBodoe/Glimt |
| 30 Sep 21 | r02 | AlashkertAlashkert | 2 - 4 | HJK HelsinkiHJK Helsinki |
| 30 Sep 21 | r02 | LASKLASK | 1 - 1 | Maccabi Tel AvivMaccabi Tel A |
| 30 Sep 21 | r02 | GentGent | 2 - 0 | Anorthosis FamagustaAnorthosis Fa |
| 30 Sep 21 | r02 | ZoryaZorya | 0 - 3 | RomaRoma |
| 30 Sep 21 | r02 | AZ AlkmaarAZ Alkmaar | 1 - 0 | JablonecJablonec |
| 30 Sep 21 | r02 | CFR Cluj-NapocaCFR Cluj-Napo | 1 - 1 | Randers FCRanders FC |
| 30 Sep 21 | r02 | FeyenoordFeyenoord | 2 - 1 | Slavia PragueSlavia Prague |
| 30 Sep 21 | r02 | Union BerlinUnion Berlin | 3 - 0 | Maccabi HaifaMaccabi Haifa |
| 30 Sep 21 | r02 | PAOKPAOK | 1 - 1 | Slovan BratislavaSlovan Bratis |
| 30 Sep 21 | r02 | FC CopenhagenFC Copenhagen | 3 - 1 | Lincoln Red ImpsLincoln Red I |
| 30 Sep 21 | r02 | TottenhamTottenham | 5 - 1 | NŠ MuraNŠ Mura |
| 30 Sep 21 | r02 | VitesseVitesse | 1 - 2 | RennesRennes |
| 30 Sep 21 | r02 | FC BaselFC Basel | 4 - 2 | Kairat AlmatyKairat Almaty |
| 30 Sep 21 | r02 | Omonia NicosiaOmonia Nicosi | 1 - 4 | Qarabag FKQarabag FK |
| |
| 21 Oct 21 | r03 | HJK HelsinkiHJK Helsinki | 0 - 5 | Maccabi Tel AvivMaccabi Tel A |
| 21 Oct 21 | r03 | Anorthosis FamagustaAnorthosis Fa | 2 - 2 | FC Flora TallinFC Flora Tall |
| 21 Oct 21 | r03 | Bodoe/GlimtBodoe/Glimt | 6 - 1 | RomaRoma |
| 21 Oct 21 | r03 | AlashkertAlashkert | 0 - 3 | LASKLASK |
| 21 Oct 21 | r03 | FeyenoordFeyenoord | 3 - 1 | Union BerlinUnion Berlin |
| 21 Oct 21 | r03 | Maccabi HaifaMaccabi Haifa | 1 - 0 | Slavia PragueSlavia Prague |
| 21 Oct 21 | r03 | FC CopenhagenFC Copenhagen | 1 - 2 | PAOKPAOK |
| 21 Oct 21 | r03 | NŠ MuraNŠ Mura | 1 - 2 | RennesRennes |
| 21 Oct 21 | r03 | VitesseVitesse | 1 - 0 | TottenhamTottenham |
| 21 Oct 21 | r03 | Qarabag FKQarabag FK | 2 - 1 | Kairat AlmatyKairat Almaty |
| 21 Oct 21 | r03 | Partizan BelgradePartizan Belg | 0 - 1 | GentGent |
| 21 Oct 21 | r03 | CSKA SofiaCSKA Sofia | 0 - 1 | ZoryaZorya |
| 21 Oct 21 | r03 | Slovan BratislavaSlovan Bratis | 2 - 0 | Lincoln Red ImpsLincoln Red I |
| 21 Oct 21 | r03 | JablonecJablonec | 2 - 2 | Randers FCRanders FC |
| 21 Oct 21 | r03 | CFR Cluj-NapocaCFR Cluj-Napo | 0 - 1 | AZ AlkmaarAZ Alkmaar |
| 21 Oct 21 | r03 | FC BaselFC Basel | 3 - 1 | Omonia NicosiaOmonia Nicosi |
| |
| 04 Nov 21 | r04 | Kairat AlmatyKairat Almaty | 1 - 2 | Qarabag FKQarabag FK |
| 04 Nov 21 | r04 | FC Flora TallinFC Flora Tall | 2 - 2 | Anorthosis FamagustaAnorthosis Fa |
| 04 Nov 21 | r04 | Maccabi Tel AvivMaccabi Tel A | 3 - 0 | HJK HelsinkiHJK Helsinki |
| 04 Nov 21 | r04 | LASKLASK | 2 - 0 | AlashkertAlashkert |
| 04 Nov 21 | r04 | GentGent | 1 - 1 | Partizan BelgradePartizan Belg |
| 04 Nov 21 | r04 | ZoryaZorya | 2 - 0 | CSKA SofiaCSKA Sofia |
| 04 Nov 21 | r04 | AZ AlkmaarAZ Alkmaar | 2 - 0 | CFR Cluj-NapocaCFR Cluj-Napo |
| 04 Nov 21 | r04 | Randers FCRanders FC | 2 - 2 | JablonecJablonec |
| 04 Nov 21 | r04 | Lincoln Red ImpsLincoln Red I | 1 - 4 | Slovan BratislavaSlovan Bratis |
| 04 Nov 21 | r04 | Omonia NicosiaOmonia Nicosi | 1 - 1 | FC BaselFC Basel |
| 04 Nov 21 | r04 | RomaRoma | 2 - 2 | Bodoe/GlimtBodoe/Glimt |
| 04 Nov 21 | r04 | Slavia PragueSlavia Prague | 1 - 0 | Maccabi HaifaMaccabi Haifa |
| 04 Nov 21 | r04 | Union BerlinUnion Berlin | 1 - 2 | FeyenoordFeyenoord |
| 04 Nov 21 | r04 | PAOKPAOK | 1 - 2 | FC CopenhagenFC Copenhagen |
| 04 Nov 21 | r04 | RennesRennes | 1 - 0 | NŠ MuraNŠ Mura |
| 04 Nov 21 | r04 | TottenhamTottenham | 3 - 2 | VitesseVitesse |
| |
| 25 Nov 21 | r05 | Kairat AlmatyKairat Almaty | 2 - 3 | FC BaselFC Basel |
| 25 Nov 21 | r05 | FC Flora TallinFC Flora Tall | 1 - 0 | Partizan BelgradePartizan Belg |
| 25 Nov 21 | r05 | Slavia PragueSlavia Prague | 2 - 2 | FeyenoordFeyenoord |
| 25 Nov 21 | r05 | Maccabi HaifaMaccabi Haifa | 0 - 1 | Union BerlinUnion Berlin |
| 25 Nov 21 | r05 | Slovan BratislavaSlovan Bratis | 0 - 0 | PAOKPAOK |
| 25 Nov 21 | r05 | Lincoln Red ImpsLincoln Red I | 0 - 4 | FC CopenhagenFC Copenhagen |
| 25 Nov 21 | r05 | RennesRennes | 3 - 3 | VitesseVitesse |
| 25 Nov 21 | r05 | NŠ MuraNŠ Mura | 2 - 1 | TottenhamTottenham |
| 25 Nov 21 | r05 | Qarabag FKQarabag FK | 2 - 2 | Omonia NicosiaOmonia Nicosi |
| 25 Nov 21 | r05 | HJK HelsinkiHJK Helsinki | 1 - 0 | AlashkertAlashkert |
| 25 Nov 21 | r05 | Maccabi Tel AvivMaccabi Tel A | 0 - 1 | LASKLASK |
| 25 Nov 21 | r05 | Anorthosis FamagustaAnorthosis Fa | 1 - 0 | GentGent |
| 25 Nov 21 | r05 | RomaRoma | 4 - 0 | ZoryaZorya |
| 25 Nov 21 | r05 | Bodoe/GlimtBodoe/Glimt | 2 - 0 | CSKA SofiaCSKA Sofia |
| 25 Nov 21 | r05 | JablonecJablonec | 1 - 1 | AZ AlkmaarAZ Alkmaar |
| 25 Nov 21 | r05 | Randers FCRanders FC | 2 - 1 | CFR Cluj-NapocaCFR Cluj-Napo |
| |
| 09 Dec 21 | r06 | AlashkertAlashkert | 1 - 1 | Maccabi Tel AvivMaccabi Tel A |
| 09 Dec 21 | r06 | LASKLASK | 3 - 0 | HJK HelsinkiHJK Helsinki |
| 09 Dec 21 | r06 | GentGent | 1 - 0 | FC Flora TallinFC Flora Tall |
| 09 Dec 21 | r06 | Partizan BelgradePartizan Belg | 1 - 1 | Anorthosis FamagustaAnorthosis Fa |
| 09 Dec 21 | r06 | ZoryaZorya | 1 - 1 | Bodoe/GlimtBodoe/Glimt |
| 09 Dec 21 | r06 | CSKA SofiaCSKA Sofia | 2 - 3 | RomaRoma |
| 09 Dec 21 | r06 | AZ AlkmaarAZ Alkmaar | 1 - 0 | Randers FCRanders FC |
| 09 Dec 21 | r06 | CFR Cluj-NapocaCFR Cluj-Napo | 2 - 0 | JablonecJablonec |
| 09 Dec 21 | r06 | FeyenoordFeyenoord | 2 - 1 | Maccabi HaifaMaccabi Haifa |
| 09 Dec 21 | r06 | Union BerlinUnion Berlin | 1 - 1 | Slavia PragueSlavia Prague |
| 09 Dec 21 | r06 | PAOKPAOK | 2 - 0 | Lincoln Red ImpsLincoln Red I |
| 09 Dec 21 | r06 | FC CopenhagenFC Copenhagen | 2 - 0 | Slovan BratislavaSlovan Bratis |
| 09 Dec 21 | r06 | TottenhamTottenham | 0 - 3 | RennesRennes |
| 09 Dec 21 | r06 | VitesseVitesse | 3 - 1 | NŠ MuraNŠ Mura |
| 09 Dec 21 | r06 | FC BaselFC Basel | 3 - 0 | Qarabag FKQarabag FK |
| 09 Dec 21 | r06 | Omonia NicosiaOmonia Nicosi | 0 - 0 | Kairat AlmatyKairat Almaty |
| |
| 17 Feb 22 | Playoff | PSV EindhovenPSV Eindhoven | 1 - 0 | Maccabi Tel AvivMaccabi Tel A |
| 17 Feb 22 | Playoff | FenerbahceFenerbahce | 2 - 3 | Slavia PragueSlavia Prague |
| 17 Feb 22 | Playoff | FC MidtjyllandFC Midtjyllan | 1 - 0 | PAOKPAOK |
| 17 Feb 22 | Playoff | Rapid ViennaRapid Vienna | 2 - 1 | VitesseVitesse |
| 17 Feb 22 | Playoff | MarseilleMarseille | 3 - 1 | Qarabag FKQarabag FK |
| 17 Feb 22 | Playoff | LeicesterLeicester | 4 - 1 | Randers FCRanders FC |
| 17 Feb 22 | Playoff | CelticCeltic | 1 - 3 | Bodoe/GlimtBodoe/Glimt |
| 17 Feb 22 | Playoff | Sparta PragueSparta Prague | 0 - 1 | Partizan BelgradePartizan Belg |
| 24 Feb 22 | Playoff | Qarabag FKQarabag FK | 0 - 3 | MarseilleMarseille |
| 24 Feb 22 | Playoff | Maccabi Tel AvivMaccabi Tel A | 1 - 1 | PSV EindhovenPSV Eindhoven |
| 24 Feb 22 | Playoff | Randers FCRanders FC | 1 - 3 | LeicesterLeicester |
| 24 Feb 22 | Playoff | Bodoe/GlimtBodoe/Glimt | 2 - 0 | CelticCeltic |
| 24 Feb 22 | Playoff | Partizan BelgradePartizan Belg | 2 - 1 | Sparta PragueSparta Prague |
| 24 Feb 22 | Playoff | Slavia PragueSlavia Prague | 3 - 2 | FenerbahceFenerbahce |
| 24 Feb 22 | Playoff | PAOKPAOK | 2 - 1 | FC MidtjyllandFC Midtjyllan |
| 24 Feb 22 | Playoff | VitesseVitesse | 2 - 0 | Rapid ViennaRapid Vienna |
| |
| 10 Mar 22 | r16 | PAOKPAOK | 1 - 0 | GentGent |
| 10 Mar 22 | r16 | VitesseVitesse | 0 - 1 | RomaRoma |
| 10 Mar 22 | r16 | Slavia PragueSlavia Prague | 4 - 1 | LASKLASK |
| 10 Mar 22 | r16 | Partizan BelgradePartizan Belg | 2 - 5 | FeyenoordFeyenoord |
| 10 Mar 22 | r16 | MarseilleMarseille | 2 - 1 | FC BaselFC Basel |
| 10 Mar 22 | r16 | LeicesterLeicester | 2 - 0 | RennesRennes |
| 10 Mar 22 | r16 | PSV EindhovenPSV Eindhoven | 4 - 4 | FC CopenhagenFC Copenhagen |
| 10 Mar 22 | r16 | Bodoe/GlimtBodoe/Glimt | 2 - 1 | AZ AlkmaarAZ Alkmaar |
| 17 Mar 22 | r16 | FC BaselFC Basel | 1 - 2 | MarseilleMarseille |
| 17 Mar 22 | r16 | RennesRennes | 2 - 1 | LeicesterLeicester |
| 17 Mar 22 | r16 | FC CopenhagenFC Copenhagen | 0 - 4 | PSV EindhovenPSV Eindhoven |
| 17 Mar 22 | r16 | AZ AlkmaarAZ Alkmaar | 2 - 2 | Bodoe/GlimtBodoe/Glimt |
| 17 Mar 22 | r16 | GentGent | 1 - 2 | PAOKPAOK |
| 17 Mar 22 | r16 | RomaRoma | 1 - 1 | VitesseVitesse |
| 17 Mar 22 | r16 | LASKLASK | 4 - 3 | Slavia PragueSlavia Prague |
| 17 Mar 22 | r16 | FeyenoordFeyenoord | 3 - 1 | Partizan BelgradePartizan Belg |
| |
| 07 Apr 22 | QF | FeyenoordFeyenoord | 3 - 3 | Slavia PragueSlavia Prague |
| 07 Apr 22 | QF | LeicesterLeicester | 0 - 0 | PSV EindhovenPSV Eindhoven |
| 07 Apr 22 | QF | Bodoe/GlimtBodoe/Glimt | 2 - 1 | RomaRoma |
| 07 Apr 22 | QF | MarseilleMarseille | 2 - 1 | PAOKPAOK |
| 14 Apr 22 | QF | PSV EindhovenPSV Eindhoven | 1 - 2 | LeicesterLeicester |
| 14 Apr 22 | QF | Slavia PragueSlavia Prague | 1 - 3 | FeyenoordFeyenoord |
| 14 Apr 22 | QF | RomaRoma | 4 - 0 | Bodoe/GlimtBodoe/Glimt |
| 14 Apr 22 | QF | PAOKPAOK | 0 - 1 | MarseilleMarseille |
| |
| 28 Apr 22 | SF | LeicesterLeicester | 1 - 1 | RomaRoma |
| 28 Apr 22 | SF | FeyenoordFeyenoord | 3 - 2 | MarseilleMarseille |
| 05 May 22 | SF | RomaRoma | 1 - 0 | LeicesterLeicester |
| 05 May 22 | SF | MarseilleMarseille | 0 - 0 | FeyenoordFeyenoord |
| |
| 25 May 22 | Final | RomaRoma | 1 - 0 | FeyenoordFeyenoord |
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