| 09 Sep 22 | r00        | Security SystemsSecurity Syst | - | Saint-Éloi LupopoSaint-Éloi Lu |
| 09 Sep 22 | r00        | Fasil KenemaFasil Kenema | 3 - 0 | BumamuruBumamuru |
| 09 Sep 22 | r00        | St Michel UnitedSt Michel Uni | - | Inter LitoralInter Litoral |
| 09 Sep 22 | r00        | MiloMilo | 2 - 1 | ASC KaraASC Kara |
| 09 Sep 22 | r00        | Les Buffles du BorgouLes Buffles d | 0 - 1 | KallonKallon |
| 10 Sep 22 | r00        | BUL Jinja FCBUL Jinja FC | 0 - 0 | Future FCFuture FC |
| 10 Sep 22 | r00        | Santé AbéchéSanté Abéché | 1 - 2 | Ferroviário BeiraFerroviário B |
| 10 Sep 22 | r00        | PWD BamendaPWD Bamenda | 1 - 1 | Elgeco PlusElgeco Plus |
| 10 Sep 22 | r00        | Ashanti Golden BoysAshanti Golde | 2 - 0 | Nouakchott KingsNouakchott Ki |
| 10 Sep 22 | r00        | ASASASAS | 0 - 0 | A.S. KigaliA.S. Kigali |
| 11 Sep 22 | r00        | Al Hilal WauAl Hilal Wau | 1 - 1 | KipangaKipanga |
| 11 Sep 22 | r00        | Mbabane HighlandersMbabane Highl | 0 - 0 | Real KingsReal Kings |
| 11 Sep 22 | r00        | Kwara UnitedKwara United | 3 - 0 | Douanes NiameyDouanes Niame |
| 11 Sep 22 | r00        | LISCRLISCR | 0 - 0 | Sporting GagnoaSporting Gagn |
| 11 Sep 22 | r00        | Al-AkhdarAl-Akhdar | 3 - 0 | Al Ahli KhartoumAl Ahli Khart |
| 11 Sep 22 | r00        | Hilal AlsahilHilal Alsahil | 1 - 0 | Geita GoldGeita Gold |
| 11 Sep 22 | r00        | FAR RabatFAR Rabat | 1 - 1 | Remo StarsRemo Stars |
| 13 Sep 22 | r00        | AS DouanesAS Douanes | 0 - 0 | Réal BamakoRéal Bamako |
| 16 Sep 22 | r00        | Saint-Éloi LupopoSaint-Éloi Lu | - | Security SystemsSecurity Syst |
| 16 Sep 22 | r00        | BumamuruBumamuru | 1 - 0 | Fasil KenemaFasil Kenema |
| 16 Sep 22 | r00        | Real KingsReal Kings | 2 - 0 | Mbabane HighlandersMbabane Highl |
| 16 Sep 22 | r00        | Inter LitoralInter Litoral | 0 - 0 | St Michel UnitedSt Michel Uni |
| 16 Sep 22 | r00        | Al Ahli KhartoumAl Ahli Khart | 0 - 0 | Al-AkhdarAl-Akhdar |
| 16 Sep 22 | r00        | Nouakchott KingsNouakchott Ki | 1 - 0 | Ashanti Golden BoysAshanti Golde |
| 17 Sep 22 | r00        | Sporting GagnoaSporting Gagn | 3 - 1 | LISCRLISCR |
| 17 Sep 22 | r00        | KallonKallon | 3 - 0 | Les Buffles du BorgouLes Buffles d |
| 17 Sep 22 | r00        | Geita GoldGeita Gold | 2 - 1 | Hilal AlsahilHilal Alsahil |
| 17 Sep 22 | r00        | KipangaKipanga | 1 - 1 | Al Hilal WauAl Hilal Wau |
| 17 Sep 22 | r00        | Future FCFuture FC | 1 - 0 | BUL Jinja FCBUL Jinja FC |
| 18 Sep 22 | r00        | Elgeco PlusElgeco Plus | 1 - 0 | PWD BamendaPWD Bamenda |
| 18 Sep 22 | r00        | Ferroviário BeiraFerroviário B | 1 - 0 | Santé AbéchéSanté Abéché |
| 18 Sep 22 | r00        | A.S. KigaliA.S. Kigali | 1 - 0 | ASASASAS |
| 18 Sep 22 | r00        | Remo StarsRemo Stars | 0 - 1 | FAR RabatFAR Rabat |
| 18 Sep 22 | r00        | Douanes NiameyDouanes Niame | 0 - 0 | Kwara UnitedKwara United |
| 18 Sep 22 | r00        | ASC KaraASC Kara | 3 - 0 | MiloMilo |
| 20 Sep 22 | r00        | Réal BamakoRéal Bamako | 0 - 0 | AS DouanesAS Douanes |
| 08 Oct 22 | r00        | St Michel UnitedSt Michel Uni | 1 - 0 | DCMP ImanaDCMP Imana |
| 08 Oct 22 | r00        | Ferroviário BeiraFerroviário B | 2 - 1 | Diables NoirsDiables Noirs |
| 08 Oct 22 | r00        | A.S. KigaliA.S. Kigali | 0 - 0 | Al-Nasr SCSCAl-Nasr SCSC |
| 08 Oct 22 | r00        | KipangaKipanga | 0 - 0 | Club AfricainClub Africain |
| 08 Oct 22 | r00        | Saint-Éloi LupopoSaint-Éloi Lu | 2 - 0 | G.D. Sagrada EsperançaG.D. Sagrada |
| 08 Oct 22 | r00        | Sporting GagnoaSporting Gagn | 1 - 0 | JS SaouraJS Saoura |
| 08 Oct 22 | r00        | Hilal AlsahilHilal Alsahil | 0 - 2 | Pyramids FCPyramids FC |
| 08 Oct 22 | r00        | Réal BamakoRéal Bamako | 3 - 0 | Hearts of OakHearts of Oak |
| 08 Oct 22 | r00        | Al-AkhdarAl-Akhdar | 3 - 0 | AzamAzam |
| 09 Oct 22 | r00        | BumamuruBumamuru | 0 - 0 | CS SfaxienCS Sfaxien |
| 09 Oct 22 | r00        | Elgeco PlusElgeco Plus | 1 - 3 | TT MadzivhandilaTT Madzivhand |
| 09 Oct 22 | r00        | Real KingsReal Kings | 0 - 0 | ZESCO UnitedZESCO United |
| 09 Oct 22 | r00        | Kwara UnitedKwara United | 3 - 1 | RS BerkaneRS Berkane |
| 09 Oct 22 | r00        | KallonKallon | 0 - 2 | Future FCFuture FC |
| 09 Oct 22 | r00        | ASC KaraASC Kara | 0 - 2 | USM AlgerUSM Alger |
| 09 Oct 22 | r00        | FAR RabatFAR Rabat | 4 - 0 | Ashanti Golden BoysAshanti Golde |
| 14 Oct 22 | r00        | Ashanti Golden BoysAshanti Golde | 0 - 1 | FAR RabatFAR Rabat |
| 15 Oct 22 | r00        | ZESCO UnitedZESCO United | 1 - 1 | Real KingsReal Kings |
| 15 Oct 22 | r00        | TT MadzivhandilaTT Madzivhand | 1 - 0 | Elgeco PlusElgeco Plus |
| 15 Oct 22 | r00        | JS SaouraJS Saoura | 0 - 0 | Sporting GagnoaSporting Gagn |
| 15 Oct 22 | r00        | CS SfaxienCS Sfaxien | 1 - 0 | BumamuruBumamuru |
| 15 Oct 22 | r00        | G.D. Sagrada EsperançaG.D. Sagrada | 0 - 0 | Saint-Éloi LupopoSaint-Éloi Lu |
| 15 Oct 22 | r00        | Pyramids FCPyramids FC | 7 - 0 | Hilal AlsahilHilal Alsahil |
| 15 Oct 22 | r00        | RS BerkaneRS Berkane | 2 - 0 | Kwara UnitedKwara United |
| 16 Oct 22 | r00        | DCMP ImanaDCMP Imana | 2 - 0 | St Michel UnitedSt Michel Uni |
| 16 Oct 22 | r00        | Diables NoirsDiables Noirs | 3 - 0 | Ferroviário BeiraFerroviário B |
| 16 Oct 22 | r00        | Club AfricainClub Africain | 7 - 0 | KipangaKipanga |
| 16 Oct 22 | r00        | Hearts of OakHearts of Oak | 1 - 0 | Réal BamakoRéal Bamako |
| 16 Oct 22 | r00        | AzamAzam | 2 - 0 | Al-AkhdarAl-Akhdar |
| 16 Oct 22 | r00        | Future FCFuture FC | 4 - 0 | KallonKallon |
| 16 Oct 22 | r00        | Al-Nasr SCSCAl-Nasr SCSC | 1 - 0 | A.S. KigaliA.S. Kigali |
| 16 Oct 22 | r00        | USM AlgerUSM Alger | 2 - 1 | ASC KaraASC Kara |
| 02 Nov 22 | r00        | TP MazembeTP Mazembe | 2 - 0 | Real KingsReal Kings |
| 02 Nov 22 | r00        | Royal LeopardsRoyal Leopard | 1 - 1 | Réal BamakoRéal Bamako |
| 02 Nov 22 | r00        | Rivers UnitedRivers United | 5 - 0 | Al-Nasr SCSCAl-Nasr SCSC |
| 02 Nov 22 | r00        | Flambeau du CentreFlambeau du C | 0 - 2 | DCMP ImanaDCMP Imana |
| 02 Nov 22 | r00        | Young AfricansYoung African | 0 - 0 | Club AfricainClub Africain |
| 02 Nov 22 | r00        | Rail Club du KadiogoRail Club du | 0 - 1 | Saint-Éloi LupopoSaint-Éloi Lu |
| 02 Nov 22 | r00        | DjolibaDjoliba | 0 - 0 | FAR RabatFAR Rabat |
| 02 Nov 22 | r00        | Primeiro de AgostoPrimeiro de A | 1 - 1 | Future FCFuture FC |
| 02 Nov 22 | r00        | Plateau UnitedPlateau Unite | 4 - 1 | Al-AkhdarAl-Akhdar |
| 02 Nov 22 | r00        | ASC KaraASC Kara | 2 - 1 | CS SfaxienCS Sfaxien |
| 02 Nov 22 | r00        | NigelecNigelec | 1 - 0 | Pyramids FCPyramids FC |
| 02 Nov 22 | r00        | ASEC MimosasASEC Mimosas | 2 - 0 | Sporting GagnoaSporting Gagn |
| 02 Nov 22 | r00        | Cape Town CityCape Town Cit | 0 - 0 | USM AlgerUSM Alger |
| 02 Nov 22 | r00        | US MonastirUS Monastir | 1 - 0 | RS BerkaneRS Berkane |
| 02 Nov 22 | r00        | Al Ahli TripoliAl Ahli Tripo | 1 - 0 | TT MadzivhandilaTT Madzivhand |
| 04 Nov 22 | r00        | La PasseLa Passe | 0 - 2 | Diables NoirsDiables Noirs |
| 09 Nov 22 | r00        | TT MadzivhandilaTT Madzivhand | 3 - 0 | Al Ahli TripoliAl Ahli Tripo |
| 09 Nov 22 | r00        | CS SfaxienCS Sfaxien | 0 - 0 | ASC KaraASC Kara |
| 09 Nov 22 | r00        | Saint-Éloi LupopoSaint-Éloi Lu | 1 - 0 | Rail Club du KadiogoRail Club du |
| 09 Nov 22 | r00        | Diables NoirsDiables Noirs | 4 - 2 | La PasseLa Passe |
| 09 Nov 22 | r00        | Al-AkhdarAl-Akhdar | 3 - 0 | Plateau UnitedPlateau Unite |
| 09 Nov 22 | r00        | Sporting GagnoaSporting Gagn | 2 - 3 | ASEC MimosasASEC Mimosas |
| 09 Nov 22 | r00        | Future FCFuture FC | 1 - 1 | Primeiro de AgostoPrimeiro de A |
| 09 Nov 22 | r00        | Réal BamakoRéal Bamako | 3 - 1 | Royal LeopardsRoyal Leopard |
| 09 Nov 22 | r00        | Pyramids FCPyramids FC | 3 - 0 | NigelecNigelec |
| 09 Nov 22 | r00        | Real KingsReal Kings | 0 - 1 | TP MazembeTP Mazembe |
| 09 Nov 22 | r00        | Club AfricainClub Africain | 0 - 1 | Young AfricansYoung African |
| 09 Nov 22 | r00        | USM AlgerUSM Alger | 1 - 0 | Cape Town CityCape Town Cit |
| 09 Nov 22 | r00        | DCMP ImanaDCMP Imana | 2 - 1 | Flambeau du CentreFlambeau du C |
| 09 Nov 22 | r00        | Al-Nasr SCSCAl-Nasr SCSC | 1 - 1 | Rivers UnitedRivers United |
| 09 Nov 22 | r00        | FAR RabatFAR Rabat | 4 - 0 | DjolibaDjoliba |
| 09 Nov 22 | r00        | RS BerkaneRS Berkane | 0 - 0 | US MonastirUS Monastir |
| 23 Apr 23 | r00        | Rivers UnitedRivers United | 0 - 2 | Young AfricansYoung African |
| 23 Apr 23 | r00        | Pyramids FCPyramids FC | 1 - 1 | TT MadzivhandilaTT Madzivhand |
| 23 Apr 23 | r00        | US MonastirUS Monastir | 0 - 0 | ASEC MimosasASEC Mimosas |
| 23 Apr 23 | r00        | USM AlgerUSM Alger | 2 - 0 | FAR RabatFAR Rabat |
| 30 Apr 23 | r00        | TT MadzivhandilaTT Madzivhand | 1 - 0 | Pyramids FCPyramids FC |
| 30 Apr 23 | r00        | ASEC MimosasASEC Mimosas | 2 - 0 | US MonastirUS Monastir |
| 30 Apr 23 | r00        | Young AfricansYoung African | 0 - 0 | Rivers UnitedRivers United |
| 30 Apr 23 | r00        | FAR RabatFAR Rabat | 3 - 2 | USM AlgerUSM Alger |
| 10 May 23 | r00        | Young AfricansYoung African | 2 - 0 | TT MadzivhandilaTT Madzivhand |
| 10 May 23 | r00        | ASEC MimosasASEC Mimosas | 0 - 0 | USM AlgerUSM Alger |
| 17 May 23 | r00        | TT MadzivhandilaTT Madzivhand | 1 - 2 | Young AfricansYoung African |
| 17 May 23 | r00        | USM AlgerUSM Alger | 2 - 0 | ASEC MimosasASEC Mimosas |
| 28 May 23 | r00        | Young AfricansYoung African | 1 - 2 | USM AlgerUSM Alger |
| 03 Jun 23 | r00        | USM AlgerUSM Alger | 0 - 1 | Young AfricansYoung African |