| 17 Oct 21 | r02        | Bayelsa UnitedBayelsa Unite | 1 - 0 | CS SfaxienCS Sfaxien |
| 23 Oct 21 | r02        | Coton Sport FC de GarouaCoton Sport F | 1 - 0 | MangasportMangasport |
| 23 Oct 21 | r02        | Al-MasryAl-Masry | 1 - 0 | URAURA |
| 23 Oct 21 | r02        | CS SfaxienCS Sfaxien | 4 - 0 | Bayelsa UnitedBayelsa Unite |
| 23 Oct 21 | r02        | JS SaouraJS Saoura | 1 - 1 | ConcordeConcorde |
| 23 Oct 21 | r02        | Pyramids FCPyramids FC | 1 - 0 | AzamAzam |
| 24 Oct 21 | r02        | Primeiro de AgostoPrimeiro de A | 0 - 0 | Red ArrowsRed Arrows |
| 24 Oct 21 | r02        | EnyimbaEnyimba | 3 - 0 | DiambarsDiambars |
| 24 Oct 21 | r02        | Orlando PiratesOrlando Pirat | 1 - 0 | Diables NoirsDiables Noirs |
| 24 Oct 21 | r02        | RS BerkaneRS Berkane | 4 - 0 | US Ben GuerdaneUS Ben Guerda |
| 24 Oct 21 | r02        | JS KabylieJS Kabylie | 2 - 1 | FAR RabatFAR Rabat |
| 20 Feb 22 | r02        | ZanacoZanaco | 0 - 2 | Pyramids FCPyramids FC |
| 20 Feb 22 | r02        | Al-Ittihad TripoliAl-Ittihad Tr | 3 - 2 | Orlando PiratesOrlando Pirat |
| 20 Feb 22 | r02        | Al-MasryAl-Masry | 2 - 0 | TP MazembeTP Mazembe |
| 20 Feb 22 | r02        | ASEC MimosasASEC Mimosas | 3 - 1 | RS BerkaneRS Berkane |
| 20 Feb 22 | r02        | US GNUS GN | 1 - 1 | Simba SCSimba SC |
| 20 Feb 22 | r02        | Al Ahli TripoliAl Ahli Tripo | 2 - 1 | CS SfaxienCS Sfaxien |
| 20 Feb 22 | r02        | JS SaouraJS Saoura | 2 - 0 | Royal LeopardsRoyal Leopard |
| 23 Feb 22 | r02        | AS OtohôAS Otohô | 1 - 1 | Coton Sport FC de GarouaCoton Sport F |