| 10 Sep 21 | r00  | Olympique de MissiriOlympique de | 1 - 2 | A.S. KigaliA.S. Kigali |
| 10 Sep 21 | r00 | BumamuruBumamuru | 0 - 0 | Diables NoirsDiables Noirs |
| 10 Sep 21 | r00 | DikhilDikhil | 0 - 1 | Biashara UnitedBiashara Unit |
| 11 Sep 21 | r00 | Red ArrowsRed Arrows | 2 - 1 | Young BuffaloesYoung Buffalo |
| 11 Sep 21 | r00 | AtlabaraAtlabara | 0 - 2 | Al-Ahly MeroweAl-Ahly Merow |
| 11 Sep 21 | r00 | Futuro Kings FCFuturo Kings | 2 - 1 | TT MadzivhandilaTT Madzivhand |
| 11 Sep 21 | r00 | AzamAzam | 3 - 1 | Horseed FCHorseed FC |
| 11 Sep 21 | r00 | BingaBinga | 3 - 0 | MC BreweriesMC Breweries |
| 12 Sep 21 | r00 | URAURA | 2 - 1 | Ethiopia BunnaEthiopia Bunn |
| 12 Sep 21 | r00 | CFFACFFA | 0 - 0 | Kabwe WarriorsKabwe Warrior |
| 12 Sep 21 | r00 | MangasportMangasport | 0 - 0 | Orapa United F.C.Orapa United |
| 12 Sep 21 | r00 | ASFA-YennengaASFA-Yennenga | 0 - 0 | FC San PédroFC San Pédro |
| 12 Sep 21 | r00 | ASC KaraASC Kara | 3 - 0 | ConcordeConcorde |
| 12 Sep 21 | r00 | MafunzoMafunzo | 0 - 1 | InterclubeInterclube |
| 12 Sep 21 | r00 | DiambarsDiambars | 3 - 0 | WakriyaWakriya |
| 12 Sep 21 | r00 | FAR RabatFAR Rabat | 3 - 0 | Les Buffles du BorgouLes Buffles d |
| 13 Sep 21 | r00 | Hay Al WadiHay Al Wadi | - | Al Ahli TripoliAl Ahli Tripo |
| 17 Sep 21 | r00 | TT MadzivhandilaTT Madzivhand | 3 - 0 | Futuro Kings FCFuturo Kings |
| 17 Sep 21 | r00 | Al-Ahly MeroweAl-Ahly Merow | 2 - 0 | AtlabaraAtlabara |
| 18 Sep 21 | r00 | A.S. KigaliA.S. Kigali | 6 - 0 | Olympique de MissiriOlympique de |
| 18 Sep 21 | r00 | Les Buffles du BorgouLes Buffles d | 0 - 0 | FAR RabatFAR Rabat |
| 18 Sep 21 | r00 | Biashara UnitedBiashara Unit | 2 - 0 | DikhilDikhil |
| 18 Sep 21 | r00 | Young BuffaloesYoung Buffalo | 0 - 0 | Red ArrowsRed Arrows |
| 18 Sep 21 | r00 | Horseed FCHorseed FC | 0 - 1 | AzamAzam |
| 18 Sep 21 | r00 | Orapa United F.C.Orapa United | 0 - 0 | MangasportMangasport |
| 18 Sep 21 | r00 | Diables NoirsDiables Noirs | 1 - 0 | BumamuruBumamuru |
| 19 Sep 21 | r00 | FC San PédroFC San Pédro | 1 - 2 | ASFA-YennengaASFA-Yennenga |
| 19 Sep 21 | r00 | Ethiopia BunnaEthiopia Bunn | 1 - 3 | URAURA |
| 19 Sep 21 | r00 | Kabwe WarriorsKabwe Warrior | 1 - 2 | CFFACFFA |
| 19 Sep 21 | r00 | InterclubeInterclube | 3 - 0 | MafunzoMafunzo |
| 19 Sep 21 | r00 | Ashanti Golden BoysAshanti Golde | 4 - 2 | Bayelsa UnitedBayelsa Unite |
| 19 Sep 21 | r00 | Bayelsa UnitedBayelsa Unite | - | Ashanti Golden BoysAshanti Golde |
| 19 Sep 21 | r00 | MC BreweriesMC Breweries | 0 - 2 | BingaBinga |
| 19 Sep 21 | r00 | WakriyaWakriya | - | DiambarsDiambars |
| 19 Sep 21 | r00 | Al Ahli TripoliAl Ahli Tripo | 4 - 0 | Hay Al WadiHay Al Wadi |
| 19 Sep 21 | r00 | ConcordeConcorde | 4 - 0 | ASC KaraASC Kara |
| 15 Oct 21 | r00 | Biashara UnitedBiashara Unit | 2 - 0 | Al Ahli TripoliAl Ahli Tripo |
| 15 Oct 21 | r00 | Diables NoirsDiables Noirs | 0 - 0 | Orlando PiratesOrlando Pirat |
| 15 Oct 21 | r00 | Futuro Kings FCFuturo Kings | 2 - 1 | Vita ClubVita Club |
| 15 Oct 21 | r00 | BingaBinga | 0 - 1 | ASFA-YennengaASFA-Yennenga |
| 15 Oct 21 | r00 | Al-Ahly MeroweAl-Ahly Merow | 1 - 3 | GOR MahiaGOR Mahia |
| 16 Oct 21 | r00 | AzamAzam | 0 - 0 | Pyramids FCPyramids FC |
| 16 Oct 21 | r00 | MangasportMangasport | 2 - 1 | Coton Sport FC de GarouaCoton Sport F |
| 16 Oct 21 | r00 | URAURA | 0 - 0 | Al-MasryAl-Masry |
| 16 Oct 21 | r00 | Red ArrowsRed Arrows | 1 - 0 | Primeiro de AgostoPrimeiro de A |
| 16 Oct 21 | r00 | US Ben GuerdaneUS Ben Guerda | 0 - 1 | RS BerkaneRS Berkane |
| 16 Oct 21 | r00 | ConcordeConcorde | 1 - 2 | JS SaouraJS Saoura |
| 16 Oct 21 | r00 | DiambarsDiambars | 0 - 1 | EnyimbaEnyimba |
| 16 Oct 21 | r00 | FAR RabatFAR Rabat | 0 - 1 | JS KabylieJS Kabylie |
| 17 Oct 21 | r00 | A.S. KigaliA.S. Kigali | 1 - 2 | DCMP ImanaDCMP Imana |
| 17 Oct 21 | r00 | CFFACFFA | 0 - 3 | InterclubeInterclube |
| 17 Oct 21 | r00 | Bayelsa UnitedBayelsa Unite | 1 - 0 | CS SfaxienCS Sfaxien |
| 22 Oct 21 | r00 | Vita ClubVita Club | 1 - 1 | Futuro Kings FCFuturo Kings |
| 22 Oct 21 | r00 | InterclubeInterclube | - | CFFACFFA |
| 23 Oct 21 | r00 | Coton Sport FC de GarouaCoton Sport F | 1 - 0 | MangasportMangasport |
| 23 Oct 21 | r00 | ASFA-YennengaASFA-Yennenga | 0 - 1 | BingaBinga |
| 23 Oct 21 | r00 | Al Ahli TripoliAl Ahli Tripo | 3 - 0 | Biashara UnitedBiashara Unit |
| 23 Oct 21 | r00 | CS SfaxienCS Sfaxien | 4 - 0 | Bayelsa UnitedBayelsa Unite |
| 23 Oct 21 | r00 | Al-MasryAl-Masry | 1 - 0 | URAURA |
| 23 Oct 21 | r00 | JS SaouraJS Saoura | 1 - 1 | ConcordeConcorde |
| 23 Oct 21 | r00 | Pyramids FCPyramids FC | 1 - 0 | AzamAzam |
| 24 Oct 21 | r00 | GOR MahiaGOR Mahia | - | Al-Ahly MeroweAl-Ahly Merow |
| 24 Oct 21 | r00 | DCMP ImanaDCMP Imana | 2 - 1 | A.S. KigaliA.S. Kigali |
| 24 Oct 21 | r00 | EnyimbaEnyimba | 3 - 0 | DiambarsDiambars |
| 24 Oct 21 | r00 | Primeiro de AgostoPrimeiro de A | 0 - 0 | Red ArrowsRed Arrows |
| 24 Oct 21 | r00 | Orlando PiratesOrlando Pirat | 1 - 0 | Diables NoirsDiables Noirs |
| 24 Oct 21 | r00 | RS BerkaneRS Berkane | 4 - 0 | US Ben GuerdaneUS Ben Guerda |
| 24 Oct 21 | r00 | JS KabylieJS Kabylie | 2 - 1 | FAR RabatFAR Rabat |
| 28 Nov 21 | r00 | TuskerTusker | 0 - 0 | CS SfaxienCS Sfaxien |
| 28 Nov 21 | r00 | ZanacoZanaco | 3 - 0 | BingaBinga |
| 28 Nov 21 | r00 | Simba SCSimba SC | 3 - 0 | Red ArrowsRed Arrows |
| 28 Nov 21 | r00 | APRAPR | 0 - 0 | RS BerkaneRS Berkane |
| 28 Nov 21 | r00 | Royal LeopardsRoyal Leopard | 1 - 0 | JS KabylieJS Kabylie |
| 28 Nov 21 | r00 | TP MazembeTP Mazembe | 1 - 0 | TT MadzivhandilaTT Madzivhand |
| 28 Nov 21 | r00 | AS OtohôAS Otohô | 1 - 0 | GOR MahiaGOR Mahia |
| 28 Nov 21 | r00 | Hearts of OakHearts of Oak | 2 - 0 | JS SaouraJS Saoura |
| 28 Nov 21 | r00 | Rivers UnitedRivers United | 2 - 1 | Al-MasryAl-Masry |
| 28 Nov 21 | r00 | Maniema UnionManiema Union | 0 - 1 | Pyramids FCPyramids FC |
| 28 Nov 21 | r00 | US GNUS GN | 2 - 0 | DCMP ImanaDCMP Imana |
| 28 Nov 21 | r00 | ASEC MimosasASEC Mimosas | 2 - 0 | InterclubeInterclube |
| 28 Nov 21 | r00 | NouadhibouNouadhibou | 0 - 0 | Coton Sport FC de GarouaCoton Sport F |
| 28 Nov 21 | r00 | Stade MalienStade Malien | 1 - 0 | Al Ahli TripoliAl Ahli Tripo |
| 28 Nov 21 | r00 | LPRC OilersLPRC Oilers | 0 - 2 | Orlando PiratesOrlando Pirat |
| 05 Dec 21 | r00 | Red ArrowsRed Arrows | 2 - 1 | Simba SCSimba SC |
| 05 Dec 21 | r00 | GOR MahiaGOR Mahia | 1 - 1 | AS OtohôAS Otohô |
| 05 Dec 21 | r00 | TT MadzivhandilaTT Madzivhand | 0 - 0 | TP MazembeTP Mazembe |
| 05 Dec 21 | r00 | InterclubeInterclube | 2 - 3 | ASEC MimosasASEC Mimosas |
| 05 Dec 21 | r00 | Coton Sport FC de GarouaCoton Sport F | 2 - 0 | NouadhibouNouadhibou |
| 05 Dec 21 | r00 | DCMP ImanaDCMP Imana | 1 - 0 | US GNUS GN |
| 05 Dec 21 | r00 | EnyimbaEnyimba | 2 - 0 | Al-Ittihad TripoliAl-Ittihad Tr |
| 05 Dec 21 | r00 | Orlando PiratesOrlando Pirat | - | LPRC OilersLPRC Oilers |
| 05 Dec 21 | r00 | Al-MasryAl-Masry | 1 - 0 | Rivers UnitedRivers United |
| 05 Dec 21 | r00 | Al Ahli TripoliAl Ahli Tripo | 1 - 0 | Stade MalienStade Malien |
| 05 Dec 21 | r00 | Pyramids FCPyramids FC | 1 - 0 | Maniema UnionManiema Union |
| 05 Dec 21 | r00 | BingaBinga | 2 - 0 | ZanacoZanaco |
| 05 Dec 21 | r00 | JS SaouraJS Saoura | 4 - 0 | Hearts of OakHearts of Oak |
| 05 Dec 21 | r00 | CS SfaxienCS Sfaxien | 1 - 0 | TuskerTusker |
| 05 Dec 21 | r00 | RS BerkaneRS Berkane | 2 - 1 | APRAPR |
| 19 Dec 21 | r00 | Al-Ittihad TripoliAl-Ittihad Tr | P - P | EnyimbaEnyimba |
| 06 Feb 22 | r00 | JS KabylieJS Kabylie | 2 - 1 | Royal LeopardsRoyal Leopard |
Team 2021-2022 Schedules
15 de Agosto
Aigle Royal
Al-Merreikh Juba
AS Otohô
AS Port
Bhantal
Djabal Club
Djoliba
Fanalamanga
FC 105 Libreville
Ferroviário de Maputo
Foresters
Gbohloé-Su des Lacs
Mighty Wanderers
Nigelec
Pamplemousses SC
Singida Black Stars
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