| 08 Jul 22 | r21        | Bentleigh Greens SCBentleigh Gre | 3 - 0 | Eastern Lions SCEastern Lions |
| 09 Jul 22 | r21        | Avondale FCAvondale FC | 1 - 4 | Oakleigh Cannons FCOakleigh Cann |
| 09 Jul 22 | r21        | Dandenong City SCDandenong Cit | 2 - 1 | Altona Magic SCAltona Magic |
| 09 Jul 22 | r21        | Port Melbourne SCPort Melbourn | 4 - 0 | Heidelberg United FCHeidelberg Un |
| 09 Jul 22 | r21        | South Melbourne FCSouth Melbour | 2 - 1 | Dandenong Thunder SCDandenong Thu |
| 10 Jul 22 | r21        | St Albans Saints SCSt Albans Sai | 0 - 1 | Hume City FCHume City FC |
| 05 Aug 22 | r21        | Melbourne KnightsMelbourne Kni | 2 - 0 | Green Gully SCGreen Gully S |