| 22 Apr 22 | r10        | Green Gully SCGreen Gully S | 1 - 0 | Hume City FCHume City FC |
| 23 Apr 22 | r10        | Eastern Lions SCEastern Lions | 1 - 2 | St Albans Saints SCSt Albans Sai |
| 23 Apr 22 | r10        | Port Melbourne SCPort Melbourn | 0 - 2 | Avondale FCAvondale FC |
| 23 Apr 22 | r10        | Dandenong Thunder SCDandenong Thu | 3 - 1 | Melbourne KnightsMelbourne Kni |
| 25 Apr 22 | r10        | Oakleigh Cannons FCOakleigh Cann | 1 - 0 | Bentleigh Greens SCBentleigh Gre |
| 25 Apr 22 | r10        | Altona Magic SCAltona Magic | 0 - 1 | South Melbourne FCSouth Melbour |
| 24 Jul 22 | r10        | Heidelberg United FCHeidelberg Un | 5 - 1 | Dandenong City SCDandenong Cit |