| 08 Apr 22 | r08        | Green Gully SCGreen Gully S | 2 - 1 | Melbourne KnightsMelbourne Kni |
| 08 Apr 22 | r08        | Oakleigh Cannons FCOakleigh Cann | 6 - 2 | Avondale FCAvondale FC |
| 09 Apr 22 | r08        | Eastern Lions SCEastern Lions | 1 - 4 | Bentleigh Greens SCBentleigh Gre |
| 09 Apr 22 | r08        | Altona Magic SCAltona Magic | 2 - 0 | Dandenong City SCDandenong Cit |
| 09 Apr 22 | r08        | Hume City FCHume City FC | 1 - 2 | St Albans Saints SCSt Albans Sai |
| 09 Apr 22 | r08        | Dandenong Thunder SCDandenong Thu | 1 - 1 | South Melbourne FCSouth Melbour |
| 10 Apr 22 | r08        | Heidelberg United FCHeidelberg Un | 0 - 1 | Port Melbourne SCPort Melbourn |