| 01 Apr 22 | r07        | Dandenong City SCDandenong Cit | 0 - 4 | Oakleigh Cannons FCOakleigh Cann |
| 01 Apr 22 | r07        | Melbourne KnightsMelbourne Kni | 3 - 0 | Hume City FCHume City FC |
| 01 Apr 22 | r07        | Bentleigh Greens SCBentleigh Gre | 3 - 0 | Green Gully SCGreen Gully S |
| 02 Apr 22 | r07        | Port Melbourne SCPort Melbourn | 1 - 0 | Altona Magic SCAltona Magic |
| 02 Apr 22 | r07        | South Melbourne FCSouth Melbour | 5 - 0 | Eastern Lions SCEastern Lions |
| 02 Apr 22 | r07        | Dandenong Thunder SCDandenong Thu | 2 - 1 | Avondale FCAvondale FC |
| 03 Apr 22 | r07        | Heidelberg United FCHeidelberg Un | 0 - 2 | St Albans Saints SCSt Albans Sai |