| 18 Mar 22 | r05        | Dandenong City SCDandenong Cit | 2 - 2 | Eastern Lions SCEastern Lions |
| 18 Mar 22 | r05        | Melbourne KnightsMelbourne Kni | 0 - 4 | Heidelberg United FCHeidelberg Un |
| 18 Mar 22 | r05        | South Melbourne FCSouth Melbour | 5 - 0 | Hume City FCHume City FC |
| 18 Mar 22 | r05        | Bentleigh Greens SCBentleigh Gre | 1 - 0 | St Albans Saints SCSt Albans Sai |
| 19 Mar 22 | r05        | Avondale FCAvondale FC | 1 - 0 | Green Gully SCGreen Gully S |
| 19 Mar 22 | r05        | Port Melbourne SCPort Melbourn | 1 - 0 | Dandenong Thunder SCDandenong Thu |
| 19 Mar 22 | r05        | Altona Magic SCAltona Magic | 0 - 3 | Oakleigh Cannons FCOakleigh Cann |