| 11 Mar 22 | r04        | Melbourne KnightsMelbourne Kni | 3 - 2 | Bentleigh Greens SCBentleigh Gre |
| 11 Mar 22 | r04        | Green Gully SCGreen Gully S | 1 - 0 | Dandenong City SCDandenong Cit |
| 12 Mar 22 | r04        | Eastern Lions SCEastern Lions | 0 - 3 | Port Melbourne SCPort Melbourn |
| 12 Mar 22 | r04        | Hume City FCHume City FC | 0 - 3 | Avondale FCAvondale FC |
| 12 Mar 22 | r04        | Dandenong Thunder SCDandenong Thu | 0 - 2 | Altona Magic SCAltona Magic |
| 13 Mar 22 | r04        | Heidelberg United FCHeidelberg Un | 2 - 0 | Oakleigh Cannons FCOakleigh Cann |
| 13 Mar 22 | r04        | St Albans Saints SCSt Albans Sai | 1 - 4 | South Melbourne FCSouth Melbour |