| 04 Mar 22 | r03        | Dandenong City SCDandenong Cit | 2 - 1 | Hume City FCHume City FC |
| 04 Mar 22 | r03        | South Melbourne FCSouth Melbour | 2 - 0 | Melbourne KnightsMelbourne Kni |
| 04 Mar 22 | r03        | Oakleigh Cannons FCOakleigh Cann | 2 - 1 | Dandenong Thunder SCDandenong Thu |
| 04 Mar 22 | r03        | Bentleigh Greens SCBentleigh Gre | 1 - 0 | Heidelberg United FCHeidelberg Un |
| 05 Mar 22 | r03        | Avondale FCAvondale FC | 0 - 1 | St Albans Saints SCSt Albans Sai |
| 05 Mar 22 | r03        | Port Melbourne SCPort Melbourn | 2 - 0 | Green Gully SCGreen Gully S |
| 05 Mar 22 | r03        | Altona Magic SCAltona Magic | 0 - 1 | Eastern Lions SCEastern Lions |