| 17 Feb 22 | r01        | South Melbourne FCSouth Melbour | 3 - 1 | Heidelberg United FCHeidelberg Un |
| 18 Feb 22 | r01        | Dandenong City SCDandenong Cit | 0 - 5 | Melbourne KnightsMelbourne Kni |
| 18 Feb 22 | r01        | Oakleigh Cannons FCOakleigh Cann | 2 - 3 | Green Gully SCGreen Gully S |
| 19 Feb 22 | r01        | Avondale FCAvondale FC | 3 - 1 | Bentleigh Greens SCBentleigh Gre |
| 19 Feb 22 | r01        | Port Melbourne SCPort Melbourn | 1 - 1 | St Albans Saints SCSt Albans Sai |
| 19 Feb 22 | r01        | Dandenong Thunder SCDandenong Thu | 2 - 1 | Eastern Lions SCEastern Lions |
| 19 Feb 22 | r01        | Altona Magic SCAltona Magic | 0 - 0 | Hume City FCHume City FC |