| 30 Jul 21 | r23        | Green Gully SCGreen Gully S | 0 - 2 | Bentleigh Greens SCBentleigh Gre |
| 30 Jul 21 | r23        | Dandenong City SCDandenong Cit | 2 - 0 | Melbourne KnightsMelbourne Kni |
| 31 Jul 21 | r23        | Avondale FCAvondale FC | 2 - 1 | St Albans Saints SCSt Albans Sai |
| 31 Jul 21 | r23        | Oakleigh Cannons FCOakleigh Cann | 1 - 0 | Port Melbourne SCPort Melbourn |
| 31 Jul 21 | r23        | Hume City FCHume City FC | 1 - 1 | South Melbourne FCSouth Melbour |
| 31 Jul 21 | r23        | Altona Magic SCAltona Magic | 2 - 1 | Eastern Lions SCEastern Lions |
| 01 Aug 21 | r23        | Heidelberg United FCHeidelberg Un | 0 - 1 | Dandenong Thunder SCDandenong Thu |