| 02 Jul 21 | r19        | Green Gully SCGreen Gully S | 4 - 0 | Altona Magic SCAltona Magic |
| 02 Jul 21 | r19        | Oakleigh Cannons FCOakleigh Cann | 6 - 1 | Dandenong City SCDandenong Cit |
| 03 Jul 21 | r19        | Avondale FCAvondale FC | 3 - 1 | Bentleigh Greens SCBentleigh Gre |
| 03 Jul 21 | r19        | Hume City FCHume City FC | 4 - 0 | Eastern Lions SCEastern Lions |
| 03 Jul 21 | r19        | Dandenong Thunder SCDandenong Thu | 4 - 1 | South Melbourne FCSouth Melbour |
| 04 Jul 21 | r19        | St Albans Saints SCSt Albans Sai | 0 - 4 | Port Melbourne SCPort Melbourn |
| 04 Jul 21 | r19        | Heidelberg United FCHeidelberg Un | 2 - 2 | Melbourne KnightsMelbourne Kni |