| 23 Apr 21 | r09        | Green Gully SCGreen Gully S | 2 - 2 | Melbourne KnightsMelbourne Kni |
| 23 Apr 21 | r09        | Dandenong City SCDandenong Cit | 1 - 1 | South Melbourne FCSouth Melbour |
| 23 Apr 21 | r09        | Oakleigh Cannons FCOakleigh Cann | 4 - 1 | Eastern Lions SCEastern Lions |
| 24 Apr 21 | r09        | Avondale FCAvondale FC | 2 - 1 | Dandenong Thunder SCDandenong Thu |
| 24 Apr 21 | r09        | Heidelberg United FCHeidelberg Un | 3 - 1 | Port Melbourne SCPort Melbourn |
| 24 Apr 21 | r09        | Hume City FCHume City FC | 6 - 0 | St Albans Saints SCSt Albans Sai |
| 24 Apr 21 | r09        | Altona Magic SCAltona Magic | 0 - 2 | Bentleigh Greens SCBentleigh Gre |