| 16 Apr 21 | r08        | Melbourne KnightsMelbourne Kni | 2 - 1 | Altona Magic SCAltona Magic |
| 16 Apr 21 | r08        | Port Melbourne SCPort Melbourn | 1 - 1 | Avondale FCAvondale FC |
| 16 Apr 21 | r08        | Bentleigh Greens SCBentleigh Gre | 1 - 0 | Oakleigh Cannons FCOakleigh Cann |
| 16 Apr 21 | r08        | Dandenong City SCDandenong Cit | 1 - 1 | Green Gully SCGreen Gully S |
| 17 Apr 21 | r08        | Eastern Lions SCEastern Lions | 0 - 1 | Heidelberg United FCHeidelberg Un |
| 17 Apr 21 | r08        | South Melbourne FCSouth Melbour | 2 - 0 | St Albans Saints SCSt Albans Sai |
| 17 Apr 21 | r08        | Dandenong Thunder SCDandenong Thu | 4 - 3 | Hume City FCHume City FC |