| 09 Apr 21 | r07        | Green Gully SCGreen Gully S | 0 - 1 | South Melbourne FCSouth Melbour |
| 09 Apr 21 | r07        | Oakleigh Cannons FCOakleigh Cann | 2 - 2 | Melbourne KnightsMelbourne Kni |
| 10 Apr 21 | r07        | Avondale FCAvondale FC | 2 - 0 | Eastern Lions SCEastern Lions |
| 10 Apr 21 | r07        | Altona Magic SCAltona Magic | 2 - 2 | Dandenong City SCDandenong Cit |
| 10 Apr 21 | r07        | Hume City FCHume City FC | 2 - 1 | Port Melbourne SCPort Melbourn |
| 10 Apr 21 | r07        | Dandenong Thunder SCDandenong Thu | 1 - 0 | St Albans Saints SCSt Albans Sai |
| 11 Apr 21 | r07        | Bentleigh Greens SCBentleigh Gre | 1 - 1 | Heidelberg United FCHeidelberg Un |