| 05 Mar 21 | r02        | Melbourne KnightsMelbourne Kni | 2 - 1 | Dandenong Thunder SCDandenong Thu |
| 05 Mar 21 | r02        | South Melbourne FCSouth Melbour | 1 - 1 | Eastern Lions SCEastern Lions |
| 05 Mar 21 | r02        | Green Gully SCGreen Gully S | 1 - 1 | Hume City FCHume City FC |
| 05 Mar 21 | r02        | Bentleigh Greens SCBentleigh Gre | 2 - 3 | Port Melbourne SCPort Melbourn |
| 05 Mar 21 | r02        | Dandenong City SCDandenong Cit | 1 - 2 | St Albans Saints SCSt Albans Sai |
| 05 Mar 21 | r02        | Oakleigh Cannons FCOakleigh Cann | 1 - 1 | Heidelberg United FCHeidelberg Un |
| 06 Mar 21 | r02        | Altona Magic SCAltona Magic | 2 - 2 | Avondale FCAvondale FC |