| 10 Oct 18 |
r05  | Rhein-Neckar LöwenRhein-Neckar | 36 - 27 | IFK KristianstadIFK Kristians |
| 13 Oct 18 |
r05 | Beşiktaş JK HandballBeşiktaş JK H | 24 - 37 | Bjerringbro-Silkeborg HånBjerringbro-S |
| 13 Oct 18 |
r05 | Chekhovskiye MedvediChekhovskiye | 33 - 25 | RK Metalurg SkopjeRK Metalurg S |
| 13 Oct 18 |
r05 | Meshkov BrestMeshkov Brest | 21 - 29 | FC Barcelona HandbolFC Barcelona |
| 13 Oct 18 |
r05 | Montpellier HandballMontpellier H | 29 - 30 | Veszprém KCVeszprém KC |
| 13 Oct 18 |
r05 | Wacker ThunWacker Thun | 25 - 26 | CB Ademar LeónCB Ademar Leó |
| 13 Oct 18 |
r05 | HT Tatran PrešovHT Tatran Pre | 27 - 30 | Sporting CP HandballSporting CP H |
| 14 Oct 18 |
r05 | Skjern HåndboldSkjern Håndbo | 24 - 26 | Paris Saint-Germain HandbParis Saint-G |
| 14 Oct 18 |
r05 | HC Motor ZaporizhzhiaHC Motor Zapo | 35 - 27 | RK PPD ZagrebRK PPD Zagreb |
| 14 Oct 18 |
r05 | SC Pick SzegedSC Pick Szege | 30 - 28 | SG Flensburg-HandewittSG Flensburg- |
| 14 Oct 18 |
r05 | Elverum HåndballElverum Håndb | 28 - 27 | Riihimäki CocksRiihimäki Coc |
| 14 Oct 18 |
r05 | HBC NantesHBC Nantes | 38 - 27 | Celje Pivovarna LaškoCelje Pivovar |
| 14 Oct 18 |
r05 | CS Dinamo BucureștiCS Dinamo Buc | 24 - 21 | Wisła PłockWisła Płock |
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