| 19 Sep 18 | r02  | SG Flensburg-HandewittSG Flensburg- | 29 - 31 | RK PPD ZagrebRK PPD Zagreb |
| 20 Sep 18 | r02 | Wacker ThunWacker Thun | 26 - 26 | Riihimäki CocksRiihimäki Coc |
| 22 Sep 18 | r02 | Chekhovskiye MedvediChekhovskiye | 22 - 23 | Sporting CP HandballSporting CP H |
| 22 Sep 18 | r02 | Vardar 1961Vardar 1961 | 33 - 25 | IFK KristianstadIFK Kristians |
| 22 Sep 18 | r02 | FC Barcelona HandbolFC Barcelona | 31 - 28 | Veszprém KCVeszprém KC |
| 22 Sep 18 | r02 | HT Tatran PrešovHT Tatran Pre | 26 - 24 | Bjerringbro-Silkeborg HånBjerringbro-S |
| 22 Sep 18 | r02 | Vive KielceVive Kielce | 35 - 32 | Rhein-Neckar LöwenRhein-Neckar |
| 22 Sep 18 | r02 | Meshkov BrestMeshkov Brest | 26 - 23 | Montpellier HandballMontpellier H |
| 22 Sep 18 | r02 | CB Ademar LeónCB Ademar Leó | 31 - 28 | CS Dinamo BucureștiCS Dinamo Buc |
| 23 Sep 18 | r02 | Skjern HåndboldSkjern Håndbo | 37 - 33 | HC Motor ZaporizhzhiaHC Motor Zapo |
| 23 Sep 18 | r02 | RK Metalurg SkopjeRK Metalurg S | 22 - 30 | Beşiktaş JK HandballBeşiktaş JK H |
| 23 Sep 18 | r02 | Paris Saint-Germain HandbParis Saint-G | 33 - 21 | Celje Pivovarna LaškoCelje Pivovar |
| 23 Sep 18 | r02 | Elverum HåndballElverum Håndb | 28 - 30 | Wisła PłockWisła Płock |
| 23 Sep 18 | r02 | SC Pick SzegedSC Pick Szege | 30 - 28 | HBC NantesHBC Nantes |
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