| 03 Dec 15 | r10  | Kadetten SchaffhausenKadetten Scha | 24 - 23 | CS Minaur Baia MareCS Minaur Bai |
| 05 Dec 15 | r10 | Meshkov BrestMeshkov Brest | 32 - 26 | Chekhovskiye MedvediChekhovskiye |
| 05 Dec 15 | r10 | FC Porto HandballFC Porto Hand | 37 - 15 | RK VojvodinaRK Vojvodina |
| 05 Dec 15 | r10 | Vardar 1961Vardar 1961 | 34 - 24 | KIF KoldingKIF Kolding |
| 05 Dec 15 | r10 | IFK KristianstadIFK Kristians | 29 - 30 | Montpellier HandballMontpellier H |
| 05 Dec 15 | r10 | FC Barcelona HandbolFC Barcelona | 31 - 33 | Vive KielceVive Kielce |
| 05 Dec 15 | r10 | HT Tatran PrešovHT Tatran Pre | 19 - 21 | CB Ciudad de LogroñoCB Ciudad de |
| 05 Dec 15 | r10 | Wisła PłockWisła Płock | 23 - 23 | RK PPD ZagrebRK PPD Zagreb |
| 05 Dec 15 | r10 | SC Pick SzegedSC Pick Szege | 30 - 24 | Rhein-Neckar LöwenRhein-Neckar |
| 06 Dec 15 | r10 | THW KielTHW Kiel | 25 - 24 | Veszprém KCVeszprém KC |
| 06 Dec 15 | r10 | Elverum HåndballElverum Håndb | 29 - 23 | RK Metalurg SkopjeRK Metalurg S |
| 06 Dec 15 | r10 | Skjern HåndboldSkjern Håndbo | 36 - 36 | HC Motor ZaporizhzhiaHC Motor Zapo |
| 06 Dec 15 | r10 | Paris Saint-Germain HandbParis Saint-G | 32 - 27 | Celje Pivovarna LaškoCelje Pivovar |
| 06 Dec 15 | r10 | Beşiktaş JK HandballBeşiktaş JK H | 26 - 34 | SG Flensburg-HandewittSG Flensburg- |
| 10 Feb 16 | r10 | RK PPD ZagrebRK PPD Zagreb | 23 - 25 | Paris Saint-Germain HandbParis Saint-G |
| 11 Feb 16 | r10 | IFK KristianstadIFK Kristians | 35 - 35 | Vive KielceVive Kielce |
| 11 Feb 16 | r10 | Rhein-Neckar LöwenRhein-Neckar | 28 - 27 | Vardar 1961Vardar 1961 |
| 13 Feb 16 | r10 | Wisła PłockWisła Płock | 26 - 31 | Celje Pivovarna LaškoCelje Pivovar |
| 13 Feb 16 | r10 | Beşiktaş JK HandballBeşiktaş JK H | 34 - 38 | Veszprém KCVeszprém KC |
| 14 Feb 16 | r10 | Montpellier HandballMontpellier H | 23 - 31 | FC Barcelona HandbolFC Barcelona |
| 14 Feb 16 | r10 | SC Pick SzegedSC Pick Szege | 34 - 23 | KIF KoldingKIF Kolding |
| 14 Feb 16 | r10 | SG Flensburg-HandewittSG Flensburg- | 37 - 27 | THW KielTHW Kiel |
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