| 14 Oct 15 | r05  | SG Flensburg-HandewittSG Flensburg- | 33 - 25 | Beşiktaş JK HandballBeşiktaş JK H |
| 15 Oct 15 | r05 | Kadetten SchaffhausenKadetten Scha | 24 - 30 | Skjern HåndboldSkjern Håndbo |
| 17 Oct 15 | r05 | Veszprém KCVeszprém KC | 29 - 27 | THW KielTHW Kiel |
| 17 Oct 15 | r05 | Montpellier HandballMontpellier H | 30 - 26 | IFK KristianstadIFK Kristians |
| 17 Oct 15 | r05 | Rhein-Neckar LöwenRhein-Neckar | 30 - 25 | SC Pick SzegedSC Pick Szege |
| 17 Oct 15 | r05 | Vive KielceVive Kielce | 30 - 30 | FC Barcelona HandbolFC Barcelona |
| 17 Oct 15 | r05 | RK VojvodinaRK Vojvodina | 26 - 31 | CB Ciudad de LogroñoCB Ciudad de |
| 17 Oct 15 | r05 | FC Porto HandballFC Porto Hand | 29 - 28 | Meshkov BrestMeshkov Brest |
| 17 Oct 15 | r05 | RK PPD ZagrebRK PPD Zagreb | 29 - 25 | Wisła PłockWisła Płock |
| 18 Oct 15 | r05 | CS Minaur Baia MareCS Minaur Bai | 21 - 20 | RK Metalurg SkopjeRK Metalurg S |
| 18 Oct 15 | r05 | Elverum HåndballElverum Håndb | 29 - 30 | HC Motor ZaporizhzhiaHC Motor Zapo |
| 18 Oct 15 | r05 | KIF KoldingKIF Kolding | 33 - 31 | Vardar 1961Vardar 1961 |
| 18 Oct 15 | r05 | Celje Pivovarna LaškoCelje Pivovar | 30 - 32 | Paris Saint-Germain HandbParis Saint-G |
| 18 Oct 15 | r05 | HT Tatran PrešovHT Tatran Pre | 27 - 21 | Chekhovskiye MedvediChekhovskiye |
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