| 12 Sep 25 | r01  | Hearts of OakHearts of Oak | 0 - 0 | Hohoe UnitedHohoe United |
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| 22 Sep 25 | r02 | Dreams FCDreams FC | 0 - 1 | Hearts of OakHearts of Oak |
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| 26 Sep 25 | r03 | Hearts of OakHearts of Oak | 1 - 0 | Eleven WondersEleven Wonder |
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| 03 Oct 25 | r04 | Bechem UnitedBechem United | 0 - 0 | Hearts of OakHearts of Oak |
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| 13 Oct 25 | r09 | Hearts of OakHearts of Oak | 0 - 0 | Heart of LionsHeart of Lion |
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| 19 Oct 25 | r06 | Berekum ChelseaBerekum Chels | 0 - 2 | Hearts of OakHearts of Oak |
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| 26 Oct 25 | r07 | Hearts of OakHearts of Oak | 2 - 2 | Bibiani Gold StarsBibiani Gold |
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| 02 Nov 25 | r08 | Basake Holy StarsBasake Holy S | 1 - 2 | Hearts of OakHearts of Oak |
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| 09 Nov 25 | r05 | Hearts of OakHearts of Oak | 0 - 1 | Asante KotokoAsante Kotoko |
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| 15 Nov 25 | r10 | Swedru All BlacksSwedru All Bl | 0 - 0 | Hearts of OakHearts of Oak |
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| 23 Nov 25 | r11 | Young ApostlesYoung Apostle | 0 - 0 | Hearts of OakHearts of Oak |
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| 29 Nov 25 | r12 | Hearts of OakHearts of Oak | 1 - 0 | VisionVision |
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| 07 Dec 25 | r13 | Karela UnitedKarela United | 2 - 0 | Hearts of OakHearts of Oak |
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| 13 Dec 25 | r14 | Hearts of OakHearts of Oak | 1 - 0 | Nations FCNations FC |
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| 21 Dec 25 | r15 | Aduana StarsAduana Stars | 0 - 0 | Hearts of OakHearts of Oak |
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| 26 Dec 25 | r16 | Hearts of OakHearts of Oak | 1 - 0 | SamartexSamartex |
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| 04 Jan 26 | r17 | MedeamaMedeama | 1 - 0 | Hearts of OakHearts of Oak |
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| 10 Jan 26 | r18 | Hohoe UnitedHohoe United | 0 - 1 | Hearts of OakHearts of Oak |
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| 16 Jan 26 | r19 | Hearts of OakHearts of Oak | 0 - 0 | Dreams FCDreams FC |
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| 24 Jan 26 | r20 | Eleven WondersEleven Wonder | 0 - 3 | Hearts of OakHearts of Oak |
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| 01 Feb 26 | r21 | Hearts of OakHearts of Oak | 0 - 0 | Bechem UnitedBechem United |
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| 15 Feb 26 | r22 | Asante KotokoAsante Kotoko | 0 - 1 | Hearts of OakHearts of Oak |
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| 22 Feb 26 | r23 | Hearts of OakHearts of Oak | 0 - 0 | Berekum ChelseaBerekum Chels |
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| 01 Mar 26 | r24 | Bibiani Gold StarsBibiani Gold | 2 - 1 | Hearts of OakHearts of Oak |
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| 08 Mar 26 | r25 | Hearts of OakHearts of Oak | 0 - 0 | Basake Holy StarsBasake Holy S |
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| 20 Mar 26 | r26 | Heart of LionsHeart of Lion | 0 - 0 | Hearts of OakHearts of Oak |
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| 29 Mar 26 | r27 | Hearts of OakHearts of Oak | 2 - 2 | Swedru All BlacksSwedru All Bl |
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| 05 Apr 26 | r28 | Hearts of OakHearts of Oak | 1 - 0 | Young ApostlesYoung Apostle |
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| 11 Apr 26 | r29 | VisionVision | 1 - 0 | Hearts of OakHearts of Oak |
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| 03 May 26 | r31 | Nations FCNations FC | 0 - 1 | Hearts of OakHearts of Oak |
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| 06 May 26 | r30 | Hearts of OakHearts of Oak | 0 - 0 | Karela UnitedKarela United |
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| 10 May 26 | r32 | Hearts of OakHearts of Oak | 0 - 0 | Aduana StarsAduana Stars |
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| 17 May 26 | r33 | SamartexSamartex | 1 - 0 | Hearts of OakHearts of Oak |
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| 24 May 26 | r34 | Hearts of OakHearts of Oak | 4 - 2 | MedeamaMedeama |
Team 2025-2026 Schedules
Aduana Stars
Asante Kotoko
Basake Holy Stars
Bechem United
Berekum Chelsea
Bibiani Gold Stars
Dreams FC
Eleven Wonders
Heart of Lions
Hearts of Oak
Hohoe United
Karela United
Medeama
Nations FC
Samartex
Swedru All Blacks
Vision
Young Apostles
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