| 15 Nov 20 | r01        | Ashanti GoldAshanti Gold | 2 - 2 | Karela UnitedKarela United |
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| 22 Nov 20 | r02        | Karela UnitedKarela United | 1 - 0 | Inter AlliesInter Allies |
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| 29 Nov 20 | r03        | Karela UnitedKarela United | 2 - 1 | Dreams FCDreams FC |
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| 04 Dec 20 | r04        | Hearts of OakHearts of Oak | 0 - 0 | Karela UnitedKarela United |
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| 13 Dec 20 | r05        | Karela UnitedKarela United | 2 - 0 | King FaisalKing Faisal |
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| 18 Dec 20 | r06        | Bechem UnitedBechem United | 2 - 1 | Karela UnitedKarela United |
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| 03 Jan 21 | r07        | Karela UnitedKarela United | 3 - 1 | Elmina SharksElmina Sharks |
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| 10 Jan 21 | r08        | Eleven WondersEleven Wonder | 3 - 1 | Karela UnitedKarela United |
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| 17 Jan 21 | r09        | Karela UnitedKarela United | 4 - 1 | Berekum ChelseaBerekum Chels |
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| 23 Jan 21 | r10        | Great OlympicsGreat Olympic | 0 - 0 | Karela UnitedKarela United |
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| 31 Jan 21 | r11        | Karela UnitedKarela United | 2 - 0 | MedeamaMedeama |
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| 04 Feb 21 | r12        | Legon CitiesLegon Cities | 0 - 0 | Karela UnitedKarela United |
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| 07 Feb 21 | r13        | Karela UnitedKarela United | 0 - 2 | Asante KotokoAsante Kotoko |
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| 14 Feb 21 | r14        | Ebusua DwarfsEbusua Dwarfs | 1 - 2 | Karela UnitedKarela United |
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| 21 Feb 21 | r15        | Karela UnitedKarela United | 2 - 0 | Liberty ProfessionalsLiberty Profe |
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| 24 Feb 21 | r16        | WAFAWAFA | 3 - 1 | Karela UnitedKarela United |
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| 06 Mar 21 | r17        | Karela UnitedKarela United | 2 - 1 | Aduana StarsAduana Stars |
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| 04 Apr 21 | r18        | Karela UnitedKarela United | 1 - 1 | Ashanti GoldAshanti Gold |
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| 11 Apr 21 | r19        | Inter AlliesInter Allies | 2 - 0 | Karela UnitedKarela United |
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| 19 Apr 21 | r20        | Dreams FCDreams FC | 1 - 0 | Karela UnitedKarela United |
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| 25 Apr 21 | r21        | Karela UnitedKarela United | 1 - 1 | Hearts of OakHearts of Oak |
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| 02 May 21 | r22        | King FaisalKing Faisal | 1 - 1 | Karela UnitedKarela United |
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| 09 May 21 | r23        | Karela UnitedKarela United | 2 - 1 | Bechem UnitedBechem United |
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| 12 May 21 | r24        | Elmina SharksElmina Sharks | 1 - 1 | Karela UnitedKarela United |
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| 16 May 21 | r25        | Karela UnitedKarela United | 2 - 0 | Eleven WondersEleven Wonder |
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| 23 May 21 | r26        | Berekum ChelseaBerekum Chels | 1 - 1 | Karela UnitedKarela United |
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| 28 May 21 | r27        | Karela UnitedKarela United | 1 - 1 | Great OlympicsGreat Olympic |
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| 05 Jun 21 | r28        | MedeamaMedeama | 1 - 0 | Karela UnitedKarela United |
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| 13 Jun 21 | r29        | Karela UnitedKarela United | 2 - 0 | Legon CitiesLegon Cities |
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| 23 Jun 21 | r30        | Asante KotokoAsante Kotoko | 2 - 1 | Karela UnitedKarela United |
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| 28 Jun 21 | r31        | Karela UnitedKarela United | 1 - 4 | Ebusua DwarfsEbusua Dwarfs |
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| 04 Jul 21 | r32        | Liberty ProfessionalsLiberty Profe | 3 - 2 | Karela UnitedKarela United |
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| 11 Jul 21 | r33        | Karela UnitedKarela United | 0 - 2 | WAFAWAFA |
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| 18 Jul 21 | r34        | Aduana StarsAduana Stars | 2 - 1 | Karela UnitedKarela United |