| 24 Nov 20 | r02  | Hearts of OakHearts of Oak | 2 - 2 | Ashanti GoldAshanti Gold |
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| 29 Nov 20 | r03 | Inter AlliesInter Allies | 1 - 0 | Hearts of OakHearts of Oak |
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| 04 Dec 20 | r04 | Hearts of OakHearts of Oak | 0 - 0 | Karela UnitedKarela United |
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| 13 Dec 20 | r05 | Hearts of OakHearts of Oak | 3 - 0 | Dreams FCDreams FC |
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| 16 Dec 20 | r01 | Aduana StarsAduana Stars | 2 - 0 | Hearts of OakHearts of Oak |
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| 19 Dec 20 | r06 | King FaisalKing Faisal | 1 - 2 | Hearts of OakHearts of Oak |
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| 02 Jan 21 | r07 | Hearts of OakHearts of Oak | 6 - 1 | Bechem UnitedBechem United |
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| 10 Jan 21 | r08 | Elmina SharksElmina Sharks | 1 - 1 | Hearts of OakHearts of Oak |
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| 17 Jan 21 | r09 | Hearts of OakHearts of Oak | 2 - 0 | Eleven WondersEleven Wonder |
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| 23 Jan 21 | r10 | Berekum ChelseaBerekum Chels | 0 - 0 | Hearts of OakHearts of Oak |
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| 30 Jan 21 | r11 | Hearts of OakHearts of Oak | 0 - 2 | Great OlympicsGreat Olympic |
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| 04 Feb 21 | r12 | MedeamaMedeama | 1 - 0 | Hearts of OakHearts of Oak |
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| 07 Feb 21 | r13 | Hearts of OakHearts of Oak | 1 - 1 | Legon CitiesLegon Cities |
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| 21 Feb 21 | r15 | Hearts of OakHearts of Oak | 3 - 2 | Ebusua DwarfsEbusua Dwarfs |
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| 24 Feb 21 | r16 | Liberty ProfessionalsLiberty Profe | 0 - 1 | Hearts of OakHearts of Oak |
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| 28 Feb 21 | r14 | Asante KotokoAsante Kotoko | 0 - 0 | Hearts of OakHearts of Oak |
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| 07 Mar 21 | r17 | Hearts of OakHearts of Oak | 4 - 0 | WAFAWAFA |
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| 04 Apr 21 | r18 | Hearts of OakHearts of Oak | 2 - 0 | Aduana StarsAduana Stars |
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| 10 Apr 21 | r19 | Ashanti GoldAshanti Gold | 1 - 0 | Hearts of OakHearts of Oak |
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| 18 Apr 21 | r20 | Hearts of OakHearts of Oak | 1 - 0 | Inter AlliesInter Allies |
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| 25 Apr 21 | r21 | Karela UnitedKarela United | 1 - 1 | Hearts of OakHearts of Oak |
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| 02 May 21 | r22 | Dreams FCDreams FC | 2 - 0 | Hearts of OakHearts of Oak |
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| 09 May 21 | r23 | Hearts of OakHearts of Oak | 2 - 0 | King FaisalKing Faisal |
| |
| 12 May 21 | r24 | Bechem UnitedBechem United | 0 - 1 | Hearts of OakHearts of Oak |
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| 16 May 21 | r25 | Hearts of OakHearts of Oak | 2 - 0 | Elmina SharksElmina Sharks |
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| 21 May 21 | r26 | Eleven WondersEleven Wonder | 0 - 1 | Hearts of OakHearts of Oak |
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| 30 May 21 | r27 | Hearts of OakHearts of Oak | 2 - 0 | Berekum ChelseaBerekum Chels |
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| 06 Jun 21 | r28 | Great OlympicsGreat Olympic | 1 - 1 | Hearts of OakHearts of Oak |
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| 13 Jun 21 | r29 | Hearts of OakHearts of Oak | 2 - 0 | MedeamaMedeama |
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| 24 Jun 21 | r30 | Legon CitiesLegon Cities | 1 - 2 | Hearts of OakHearts of Oak |
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| 27 Jun 21 | r31 | Hearts of OakHearts of Oak | 1 - 0 | Asante KotokoAsante Kotoko |
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| 04 Jul 21 | r32 | Ebusua DwarfsEbusua Dwarfs | 1 - 1 | Hearts of OakHearts of Oak |
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| 11 Jul 21 | r33 | Hearts of OakHearts of Oak | 1 - 1 | Liberty ProfessionalsLiberty Profe |
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| 17 Jul 21 | r34 | WAFAWAFA | 1 - 0 | Hearts of OakHearts of Oak |
Team 2020-2021 Schedules
Aduana Stars
Asante Kotoko
Basake Holy Stars
Bechem United
Berekum Chelsea
Bibiani Gold Stars
Dreams FC
Eleven Wonders
Heart of Lions
Hearts of Oak
Hohoe United
Karela United
Medeama
Nations FC
Samartex
Swedru All Blacks
Vision
Young Apostles
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