| 14 Nov 20 | r01  | Legon CitiesLegon Cities | 1 - 1 | Berekum ChelseaBerekum Chels |
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| 22 Nov 20 | r02 | Berekum ChelseaBerekum Chels | 1 - 1 | Asante KotokoAsante Kotoko |
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| 29 Nov 20 | r03 | Ebusua DwarfsEbusua Dwarfs | 1 - 0 | Berekum ChelseaBerekum Chels |
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| 05 Dec 20 | r04 | Berekum ChelseaBerekum Chels | 1 - 0 | Liberty ProfessionalsLiberty Profe |
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| 13 Dec 20 | r05 | WAFAWAFA | 2 - 0 | Berekum ChelseaBerekum Chels |
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| 21 Dec 20 | r06 | Berekum ChelseaBerekum Chels | 1 - 1 | Aduana StarsAduana Stars |
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| 03 Jan 21 | r07 | Ashanti GoldAshanti Gold | 2 - 1 | Berekum ChelseaBerekum Chels |
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| 10 Jan 21 | r08 | Berekum ChelseaBerekum Chels | 1 - 0 | Inter AlliesInter Allies |
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| 17 Jan 21 | r09 | Karela UnitedKarela United | 4 - 1 | Berekum ChelseaBerekum Chels |
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| 23 Jan 21 | r10 | Berekum ChelseaBerekum Chels | 0 - 0 | Hearts of OakHearts of Oak |
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| 30 Jan 21 | r11 | King FaisalKing Faisal | 4 - 3 | Berekum ChelseaBerekum Chels |
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| 03 Feb 21 | r12 | Berekum ChelseaBerekum Chels | 2 - 0 | Bechem UnitedBechem United |
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| 08 Feb 21 | r13 | Elmina SharksElmina Sharks | 1 - 1 | Berekum ChelseaBerekum Chels |
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| 14 Feb 21 | r14 | Berekum ChelseaBerekum Chels | 2 - 0 | Eleven WondersEleven Wonder |
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| 21 Feb 21 | r15 | Berekum ChelseaBerekum Chels | 1 - 0 | Dreams FCDreams FC |
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| 26 Feb 21 | r16 | Great OlympicsGreat Olympic | 1 - 0 | Berekum ChelseaBerekum Chels |
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| 07 Mar 21 | r17 | Berekum ChelseaBerekum Chels | 1 - 1 | MedeamaMedeama |
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| 04 Apr 21 | r18 | Berekum ChelseaBerekum Chels | 2 - 1 | Legon CitiesLegon Cities |
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| 11 Apr 21 | r19 | Asante KotokoAsante Kotoko | 2 - 0 | Berekum ChelseaBerekum Chels |
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| 18 Apr 21 | r20 | Berekum ChelseaBerekum Chels | 2 - 1 | Ebusua DwarfsEbusua Dwarfs |
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| 24 Apr 21 | r21 | Liberty ProfessionalsLiberty Profe | 2 - 0 | Berekum ChelseaBerekum Chels |
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| 30 Apr 21 | r22 | Berekum ChelseaBerekum Chels | 2 - 3 | WAFAWAFA |
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| 09 May 21 | r23 | Aduana StarsAduana Stars | 1 - 0 | Berekum ChelseaBerekum Chels |
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| 12 May 21 | r24 | Berekum ChelseaBerekum Chels | 3 - 1 | Ashanti GoldAshanti Gold |
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| 16 May 21 | r25 | Inter AlliesInter Allies | 5 - 0 | Berekum ChelseaBerekum Chels |
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| 23 May 21 | r26 | Berekum ChelseaBerekum Chels | 1 - 1 | Karela UnitedKarela United |
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| 30 May 21 | r27 | Hearts of OakHearts of Oak | 2 - 0 | Berekum ChelseaBerekum Chels |
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| 06 Jun 21 | r28 | Berekum ChelseaBerekum Chels | 5 - 0 | King FaisalKing Faisal |
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| 13 Jun 21 | r29 | Bechem UnitedBechem United | 2 - 0 | Berekum ChelseaBerekum Chels |
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| 23 Jun 21 | r30 | Berekum ChelseaBerekum Chels | 2 - 1 | Elmina SharksElmina Sharks |
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| 26 Jun 21 | r31 | Eleven WondersEleven Wonder | 3 - 1 | Berekum ChelseaBerekum Chels |
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| 04 Jul 21 | r32 | Dreams FCDreams FC | 0 - 1 | Berekum ChelseaBerekum Chels |
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| 11 Jul 21 | r33 | Berekum ChelseaBerekum Chels | 2 - 1 | Great OlympicsGreat Olympic |
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| 18 Jul 21 | r34 | MedeamaMedeama | 1 - 0 | Berekum ChelseaBerekum Chels |
Team 2020-2021 Schedules
Aduana Stars
Asante Kotoko
Basake Holy Stars
Bechem United
Berekum Chelsea
Bibiani Gold Stars
Dreams FC
Eleven Wonders
Heart of Lions
Hearts of Oak
Hohoe United
Karela United
Medeama
Nations FC
Samartex
Swedru All Blacks
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Young Apostles
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