| 15 Nov 20 | r01        | Asante KotokoAsante Kotoko | 1 - 1 | Eleven WondersEleven Wonder |
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| 22 Nov 20 | r02        | Berekum ChelseaBerekum Chels | 1 - 1 | Asante KotokoAsante Kotoko |
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| 11 Dec 20 | r05        | Asante KotokoAsante Kotoko | 1 - 0 | Legon CitiesLegon Cities |
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| 17 Dec 20 | r03        | Asante KotokoAsante Kotoko | 0 - 1 | Great OlympicsGreat Olympic |
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| 20 Dec 20 | r06        | Dreams FCDreams FC | 0 - 1 | Asante KotokoAsante Kotoko |
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| 27 Dec 20 | r04        | MedeamaMedeama | 1 - 1 | Asante KotokoAsante Kotoko |
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| 11 Jan 21 | r08        | Asante KotokoAsante Kotoko | 2 - 0 | Liberty ProfessionalsLiberty Profe |
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| 17 Jan 21 | r09        | WAFAWAFA | 1 - 1 | Asante KotokoAsante Kotoko |
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| 20 Jan 21 | r07        | Ebusua DwarfsEbusua Dwarfs | 0 - 1 | Asante KotokoAsante Kotoko |
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| 24 Jan 21 | r10        | Asante KotokoAsante Kotoko | 0 - 1 | Aduana StarsAduana Stars |
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| 31 Jan 21 | r11        | Ashanti GoldAshanti Gold | 0 - 0 | Asante KotokoAsante Kotoko |
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| 03 Feb 21 | r12        | Asante KotokoAsante Kotoko | 1 - 0 | Inter AlliesInter Allies |
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| 07 Feb 21 | r13        | Karela UnitedKarela United | 0 - 2 | Asante KotokoAsante Kotoko |
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| 28 Feb 21 | r14        | Asante KotokoAsante Kotoko | 0 - 0 | Hearts of OakHearts of Oak |
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| 05 Mar 21 | r17        | Elmina SharksElmina Sharks | 1 - 0 | Asante KotokoAsante Kotoko |
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| 10 Mar 21 | r15        | King FaisalKing Faisal | 0 - 1 | Asante KotokoAsante Kotoko |
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| 03 Apr 21 | r18        | Eleven WondersEleven Wonder | 1 - 1 | Asante KotokoAsante Kotoko |
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| 07 Apr 21 | r16        | Asante KotokoAsante Kotoko | 4 - 0 | Bechem UnitedBechem United |
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| 11 Apr 21 | r19        | Asante KotokoAsante Kotoko | 2 - 0 | Berekum ChelseaBerekum Chels |
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| 16 Apr 21 | r20        | Great OlympicsGreat Olympic | 0 - 0 | Asante KotokoAsante Kotoko |
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| 24 Apr 21 | r21        | Asante KotokoAsante Kotoko | 1 - 2 | MedeamaMedeama |
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| 01 May 21 | r22        | Legon CitiesLegon Cities | 0 - 1 | Asante KotokoAsante Kotoko |
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| 08 May 21 | r23        | Asante KotokoAsante Kotoko | 3 - 1 | Dreams FCDreams FC |
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| 13 May 21 | r24        | Asante KotokoAsante Kotoko | 2 - 1 | Ebusua DwarfsEbusua Dwarfs |
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| 16 May 21 | r25        | Liberty ProfessionalsLiberty Profe | 1 - 1 | Asante KotokoAsante Kotoko |
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| 22 May 21 | r26        | Asante KotokoAsante Kotoko | 1 - 1 | WAFAWAFA |
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| 29 May 21 | r27        | Aduana StarsAduana Stars | 0 - 0 | Asante KotokoAsante Kotoko |
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| 06 Jun 21 | r28        | Asante KotokoAsante Kotoko | 1 - 0 | Ashanti GoldAshanti Gold |
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| 14 Jun 21 | r29        | Inter AlliesInter Allies | 2 - 3 | Asante KotokoAsante Kotoko |
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| 23 Jun 21 | r30        | Asante KotokoAsante Kotoko | 2 - 1 | Karela UnitedKarela United |
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| 27 Jun 21 | r31        | Hearts of OakHearts of Oak | 1 - 0 | Asante KotokoAsante Kotoko |
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| 03 Jul 21 | r32        | Asante KotokoAsante Kotoko | 1 - 1 | King FaisalKing Faisal |
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| 11 Jul 21 | r33        | Bechem UnitedBechem United | 2 - 1 | Asante KotokoAsante Kotoko |
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| 18 Jul 21 | r34        | Asante KotokoAsante Kotoko | 0 - 1 | Elmina SharksElmina Sharks |