| 08 Nov 22 | r04  | KasimpasaKasimpasa | 6 - 1 | Hekimoğlu TrabzonHekimoğlu Tra |
| 08 Nov 22 | r04 | ErzurumsporErzurumspor | 2 - 2 | Esenler EroksporEsenler Eroks |
| 08 Nov 22 | r04 | MalatyasporMalatyaspor | 0 - 1 | Utaş UşaksporUtaş Uşakspor |
| 08 Nov 22 | r04 | AlanyasporAlanyaspor | 3 - 0 | SakaryasporSakaryaspor |
| 08 Nov 22 | r04 | AnkaragucuAnkaragucu | 6 - 2 | AmedAmed |
| 08 Nov 22 | r04 | Adana DemirsporAdana Demirsp | 4 - 3 | Nazilli BelediyesporNazilli Beled |
| 09 Nov 22 | r04 | GiresunsporGiresunspor | 3 - 2 | OsmanlısporOsmanlıspor |
| 09 Nov 22 | r04 | AltınorduAltınordu | 0 - 1 | BB BodrumsporBB Bodrumspor |
| 09 Nov 22 | r04 | BandırmasporBandırmaspor | 0 - 3 | Karacabey BelediyesporKaracabey Bel |
| 09 Nov 22 | r04 | BolusporBoluspor | 2 - 1 | Tarsus İdman YurduTarsus İdman |
| 09 Nov 22 | r04 | EyüpsporEyüpspor | 2 - 1 | DüzcesporDüzcespor |
| 09 Nov 22 | r04 | GenclerbirligiGenclerbirlig | 1 - 0 | Bayburt İÖİBayburt İÖİ |
| 09 Nov 22 | r04 | SamsunsporSamsunspor | 4 - 0 | AdanasporAdanaspor |
| 09 Nov 22 | r04 | AntalyasporAntalyaspor | 3 - 0 | PendiksporPendikspor |
| 09 Nov 22 | r04 | BesiktasBesiktas | 3 - 1 | Serik BelediyesporSerik Belediy |
| 10 Nov 22 | r04 | IstanbulsporIstanbulspor | 3 - 2 | Etimesgut BelediyesporEtimesgut Bel |
| 10 Nov 22 | r04 | GoztepeGoztepe | 2 - 0 | Bucaspor 1928Bucaspor 1928 |
| 10 Nov 22 | r04 | TuzlasporTuzlaspor | 2 - 1 | Isparta 32 SporIsparta 32 Sp |
| 10 Nov 22 | r04 | RizesporRizespor | 2 - 1 | KırklarelisporKırklarelispo |
| 10 Nov 22 | r04 | DenizlisporDenizlispor | 0 - 5 | ŞanlıurfasporŞanlıurfaspor |
| 10 Nov 22 | r04 | KaragumrukKaragumruk | 3 - 1 | Kırşehir BelediyesporKırşehir Bele |
| 10 Nov 22 | r04 | KayserisporKayserispor | 1 - 0 | Sivas BelediyesporSivas Belediy |
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