| 30 Nov 21 | r04  | BandırmasporBandırmaspor | 5 - 0 | ŞanlıurfasporŞanlıurfaspor |
| 30 Nov 21 | r04 | IstanbulsporIstanbulspor | 2 - 3 | Afjet AfyonsporAfjet Afyonsp |
| 30 Nov 21 | r04 | AltayAltay | 4 - 2 | Manisa BBSKManisa BBSK |
| 30 Nov 21 | r04 | BursasporBursaspor | 2 - 1 | Kırşehir BelediyesporKırşehir Bele |
| 30 Nov 21 | r04 | Istanbul BasaksehirIstanbul Basa | 1 - 1 | BB BodrumsporBB Bodrumspor |
| 30 Nov 21 | r04 | Adana DemirsporAdana Demirsp | 5 - 0 | Serik BelediyesporSerik Belediy |
| 30 Nov 21 | r04 | AntalyasporAntalyaspor | 4 - 0 | AmedAmed |
| 01 Dec 21 | r04 | RizesporRizespor | 0 - 1 | OsmanlısporOsmanlıspor |
| 01 Dec 21 | r04 | SamsunsporSamsunspor | 4 - 0 | Utaş UşaksporUtaş Uşakspor |
| 01 Dec 21 | r04 | AdanasporAdanaspor | 1 - 2 | KocaelisporKocaelispor |
| 01 Dec 21 | r04 | KaragumrukKaragumruk | 2 - 0 | SarıyerSarıyer |
| 01 Dec 21 | r04 | HataysporHatayspor | 1 - 1 | EyüpsporEyüpspor |
| 02 Dec 21 | r04 | GiresunsporGiresunspor | 4 - 2 | Ankara DemirsporAnkara Demirs |
| 02 Dec 21 | r04 | ÜmraniyesporÜmraniyespor | 3 - 2 | Arnavutköy BelediyesporArnavutköy Be |
| 02 Dec 21 | r04 | Menemen BelediyesporMenemen Beled | 3 - 0 | Hekimoğlu TrabzonHekimoğlu Tra |
| 02 Dec 21 | r04 | MalatyasporMalatyaspor | 3 - 1 | Akhisar BelediyesporAkhisar Beled |
| 02 Dec 21 | r04 | AnkaragucuAnkaragucu | 3 - 0 | Nazilli BelediyesporNazilli Beled |
| 02 Dec 21 | r04 | KonyasporKonyaspor | 3 - 1 | Vanspor FKVanspor FK |
| 02 Dec 21 | r04 | Gaziantep FKGaziantep FK | 3 - 1 | SakaryasporSakaryaspor |
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