| 28 Sep 21 | r00  | ElazığsporElazığspor | 0 - 1 | Arnavutköy BelediyesporArnavutköy Be |
| 26 Oct 21 | r00 | AnkaragucuAnkaragucu | 2 - 0 | SomasporSomaspor |
| 26 Oct 21 | r00 | AmedAmed | 3 - 2 | Tarsus İdman YurduTarsus İdman |
| 26 Oct 21 | r00 | EyüpsporEyüpspor | 2 - 0 | Bucaspor 1928Bucaspor 1928 |
| 26 Oct 21 | r00 | SamsunsporSamsunspor | 2 - 1 | Anadolu SelçuksporAnadolu Selçu |
| 26 Oct 21 | r00 | AdanasporAdanaspor | 2 - 0 | Adıyaman 1954Adıyaman 1954 |
| 27 Oct 21 | r00 | KocaelisporKocaelispor | 2 - 0 | Bayburt İÖİBayburt İÖİ |
| 27 Oct 21 | r00 | Vanspor FKVanspor FK | 1 - 0 | Zonguldak KömürsporZonguldak Köm |
| 27 Oct 21 | r00 | Yeni ÇorumsporYeni Çorumspo | 0 - 2 | Arnavutköy BelediyesporArnavutköy Be |
| 27 Oct 21 | r00 | Hekimoğlu TrabzonHekimoğlu Tra | 1 - 1 | DüzcesporDüzcespor |
| 27 Oct 21 | r00 | Serik BelediyesporSerik Belediy | 7 - 0 | PazarsporPazarspor |
| 27 Oct 21 | r00 | OsmanlısporOsmanlıspor | 2 - 0 | İnegölsporİnegölspor |
| 27 Oct 21 | r00 | Karacabey BelediyesporKaracabey Bel | 1 - 2 | ŞanlıurfasporŞanlıurfaspor |
| 27 Oct 21 | r00 | Afjet AfyonsporAfjet Afyonsp | 3 - 1 | Sivas BelediyesporSivas Belediy |
| 27 Oct 21 | r00 | IstanbulsporIstanbulspor | 5 - 0 | Ergene VelimeşesporErgene Velime |
| 27 Oct 21 | r00 | BB BodrumsporBB Bodrumspor | 3 - 1 | Isparta 32 SporIsparta 32 Sp |
| 27 Oct 21 | r00 | ErzurumsporErzurumspor | 0 - 0 | Nazilli BelediyesporNazilli Beled |
| 28 Oct 21 | r00 | ÜmraniyesporÜmraniyespor | 3 - 1 | KahramanmaraşsporKahramanmaraş |
| 28 Oct 21 | r00 | GenclerbirligiGenclerbirlig | 3 - 1 | PendiksporPendikspor |
| 28 Oct 21 | r00 | AntalyasporAntalyaspor | 5 - 0 | DiyarbekirsporDiyarbekirspo |
| 28 Oct 21 | r00 | Adana DemirsporAdana Demirsp | 3 - 0 | Niğde AnadoluNiğde Anadolu |
| 01 Mar 22 | r00 | TrabzonsporTrabzonspor | 2 - 0 | AntalyasporAntalyaspor |
| 02 Mar 22 | r00 | SivassporSivasspor | 1 - 0 | KaragumrukKaragumruk |
| 02 Mar 22 | r00 | BesiktasBesiktas | 1 - 2 | KayserisporKayserispor |
| 03 Mar 22 | r00 | AlanyasporAlanyaspor | 2 - 1 | Gaziantep FKGaziantep FK |
| 19 Apr 22 | r00  | TrabzonsporTrabzonspor | 1 - 0 | KayserisporKayserispor |
| 20 Apr 22 | r00 | AlanyasporAlanyaspor | 1 - 2 | SivassporSivasspor |
| 10 May 22 | r00 | KayserisporKayserispor | 4 - 2 | TrabzonsporTrabzonspor |
| 11 May 22 | r00 | SivassporSivasspor | 1 - 1 | AlanyasporAlanyaspor |
| 26 May 22 | r00 | KayserisporKayserispor | 2 - 3 | SivassporSivasspor |
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