| 17 Mar 21 | r01  | CumbayáCumbayá | 2 - 1 | GualaceoGualaceo |
| |
| 24 Mar 21 | r02 | GualaceoGualaceo | 3 - 0 | Atlético PorteñoAtlético Port |
| |
| 01 Apr 21 | r03 | ChacaritasChacaritas | 2 - 0 | GualaceoGualaceo |
| |
| 07 Apr 21 | r04 | GualaceoGualaceo | 2 - 0 | Guayaquil SCGuayaquil SC |
| |
| 14 Apr 21 | r05 | Independiente JuniorsIndependiente | 2 - 0 | GualaceoGualaceo |
| |
| 21 Apr 21 | r06 | Atlético Santo DomingoAtlético Sant | 1 - 0 | GualaceoGualaceo |
| |
| 06 May 21 | r07 | GualaceoGualaceo | 1 - 0 | El NacionalEl Nacional |
| |
| 12 May 21 | r08 | LDU PortoviejoLDU Portoviej | 3 - 1 | GualaceoGualaceo |
| |
| 19 May 21 | r09 | GualaceoGualaceo | 1 - 1 | América de QuitoAmérica de Qu |
| |
| 26 May 21 | r10 | Atlético PorteñoAtlético Port | 3 - 1 | GualaceoGualaceo |
| |
| 02 Jun 21 | r11 | GualaceoGualaceo | 0 - 0 | ChacaritasChacaritas |
| |
| 06 Jun 21 | r12 | Guayaquil SCGuayaquil SC | 1 - 1 | GualaceoGualaceo |
| |
| 09 Jun 21 | r13 | GualaceoGualaceo | 0 - 0 | Independiente JuniorsIndependiente |
| |
| 13 Jun 21 | r14 | GualaceoGualaceo | 3 - 0 | Atlético Santo DomingoAtlético Sant |
| |
| 17 Jun 21 | r15 | El NacionalEl Nacional | 1 - 1 | GualaceoGualaceo |
| |
| 20 Jun 21 | r16 | GualaceoGualaceo | 0 - 0 | LDU PortoviejoLDU Portoviej |
| |
| 25 Jun 21 | r17 | América de QuitoAmérica de Qu | 0 - 1 | GualaceoGualaceo |
| |
| 28 Jun 21 | r18 | GualaceoGualaceo | 0 - 1 | CumbayáCumbayá |
| |
| 03 Jul 21 | r19 | Atlético Santo DomingoAtlético Sant | 1 - 4 | GualaceoGualaceo |
| |
| 09 Jul 21 | r20 | Independiente JuniorsIndependiente | 1 - 3 | GualaceoGualaceo |
| |
| 11 Jul 21 | r21 | GualaceoGualaceo | 2 - 0 | Guayaquil SCGuayaquil SC |
| |
| 14 Jul 21 | r22 | ChacaritasChacaritas | 0 - 0 | GualaceoGualaceo |
| |
| 18 Jul 21 | r23 | GualaceoGualaceo | 4 - 2 | Atlético PorteñoAtlético Port |
| |
| 22 Jul 21 | r24 | CumbayáCumbayá | 2 - 1 | GualaceoGualaceo |
| |
| 28 Jul 21 | r25 | GualaceoGualaceo | 1 - 0 | América de QuitoAmérica de Qu |
| |
| 04 Aug 21 | r26 | LDU PortoviejoLDU Portoviej | 1 - 1 | GualaceoGualaceo |
| |
| 11 Aug 21 | r27 | GualaceoGualaceo | 1 - 0 | El NacionalEl Nacional |
| |
| 18 Aug 21 | r28 | GualaceoGualaceo | 2 - 0 | Independiente JuniorsIndependiente |
| |
| 26 Aug 21 | r29 | Guayaquil SCGuayaquil SC | 0 - 2 | GualaceoGualaceo |
| |
| 01 Sep 21 | r30 | GualaceoGualaceo | 0 - 1 | ChacaritasChacaritas |
| |
| 08 Sep 21 | r31 | Atlético PorteñoAtlético Port | 0 - 1 | GualaceoGualaceo |
| |
| 15 Sep 21 | r32 | GualaceoGualaceo | 3 - 1 | CumbayáCumbayá |
| |
| 22 Sep 21 | r33 | América de QuitoAmérica de Qu | 1 - 1 | GualaceoGualaceo |
| |
| 29 Sep 21 | r34 | GualaceoGualaceo | 1 - 0 | LDU PortoviejoLDU Portoviej |
| |
| 07 Oct 21 | r35 | El NacionalEl Nacional | 4 - 2 | GualaceoGualaceo |
| 07 Oct 21 | r35 | El NacionalEl Nacional | 4 - 2 | GualaceoGualaceo |
| |
| 13 Oct 21 | r36 | GualaceoGualaceo | 1 - 0 | Atlético Santo DomingoAtlético Sant |
Team 2021 Schedules
22 de Julio
9 de Octubre
Atlético FC
Cuenca Juniors
Cumbayá
Deportivo Santo Domingo
El Nacional
Gualaceo
Independiente Juniors
LDU Portoviejo
San Antonio FC
Vinotinto Ecuador
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