| 18 Mar 21 | r01  | LDU PortoviejoLDU Portoviej | 1 - 3 | Guayaquil SCGuayaquil SC |
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| 24 Mar 21 | r02 | Independiente JuniorsIndependiente | 3 - 0 | LDU PortoviejoLDU Portoviej |
| |
| 31 Mar 21 | r03 | LDU PortoviejoLDU Portoviej | 3 - 0 | El NacionalEl Nacional |
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| 07 Apr 21 | r04 | América de QuitoAmérica de Qu | 2 - 1 | LDU PortoviejoLDU Portoviej |
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| 14 Apr 21 | r05 | LDU PortoviejoLDU Portoviej | 1 - 2 | Atlético PorteñoAtlético Port |
| |
| 21 Apr 21 | r06 | LDU PortoviejoLDU Portoviej | 1 - 3 | CumbayáCumbayá |
| |
| 06 May 21 | r07 | ChacaritasChacaritas | 2 - 2 | LDU PortoviejoLDU Portoviej |
| |
| 12 May 21 | r08 | LDU PortoviejoLDU Portoviej | 3 - 1 | GualaceoGualaceo |
| |
| 20 May 21 | r09 | Atlético Santo DomingoAtlético Sant | 3 - 2 | LDU PortoviejoLDU Portoviej |
| |
| 26 May 21 | r10 | LDU PortoviejoLDU Portoviej | 2 - 2 | Independiente JuniorsIndependiente |
| |
| 03 Jun 21 | r11 | El NacionalEl Nacional | 1 - 2 | LDU PortoviejoLDU Portoviej |
| |
| 06 Jun 21 | r12 | LDU PortoviejoLDU Portoviej | 2 - 1 | América de QuitoAmérica de Qu |
| |
| 10 Jun 21 | r13 | Atlético PorteñoAtlético Port | 3 - 0 | LDU PortoviejoLDU Portoviej |
| |
| 13 Jun 21 | r14 | CumbayáCumbayá | 1 - 1 | LDU PortoviejoLDU Portoviej |
| |
| 16 Jun 21 | r15 | LDU PortoviejoLDU Portoviej | 0 - 0 | ChacaritasChacaritas |
| |
| 20 Jun 21 | r16 | GualaceoGualaceo | 0 - 0 | LDU PortoviejoLDU Portoviej |
| |
| 23 Jun 21 | r17 | LDU PortoviejoLDU Portoviej | 2 - 0 | Atlético Santo DomingoAtlético Sant |
| |
| 27 Jun 21 | r18 | Guayaquil SCGuayaquil SC | 2 - 1 | LDU PortoviejoLDU Portoviej |
| |
| 04 Jul 21 | r19 | LDU PortoviejoLDU Portoviej | 1 - 2 | CumbayáCumbayá |
| |
| 08 Jul 21 | r20 | LDU PortoviejoLDU Portoviej | 0 - 2 | Atlético PorteñoAtlético Port |
| |
| 11 Jul 21 | r21 | América de QuitoAmérica de Qu | 1 - 0 | LDU PortoviejoLDU Portoviej |
| |
| 14 Jul 21 | r22 | LDU PortoviejoLDU Portoviej | 2 - 0 | El NacionalEl Nacional |
| |
| 18 Jul 21 | r23 | Independiente JuniorsIndependiente | 3 - 1 | LDU PortoviejoLDU Portoviej |
| |
| 22 Jul 21 | r24 | LDU PortoviejoLDU Portoviej | 2 - 0 | Guayaquil SCGuayaquil SC |
| |
| 28 Jul 21 | r25 | Atlético Santo DomingoAtlético Sant | 1 - 1 | LDU PortoviejoLDU Portoviej |
| |
| 04 Aug 21 | r26 | LDU PortoviejoLDU Portoviej | 1 - 1 | GualaceoGualaceo |
| |
| 11 Aug 21 | r27 | ChacaritasChacaritas | 1 - 0 | LDU PortoviejoLDU Portoviej |
| |
| 18 Aug 21 | r28 | Atlético PorteñoAtlético Port | 0 - 2 | LDU PortoviejoLDU Portoviej |
| |
| 25 Aug 21 | r29 | LDU PortoviejoLDU Portoviej | 0 - 0 | América de QuitoAmérica de Qu |
| |
| 01 Sep 21 | r30 | El NacionalEl Nacional | 1 - 1 | LDU PortoviejoLDU Portoviej |
| |
| 08 Sep 21 | r31 | LDU PortoviejoLDU Portoviej | 0 - 1 | Independiente JuniorsIndependiente |
| |
| 15 Sep 21 | r32 | Guayaquil SCGuayaquil SC | 2 - 0 | LDU PortoviejoLDU Portoviej |
| |
| 22 Sep 21 | r33 | LDU PortoviejoLDU Portoviej | 3 - 3 | Atlético Santo DomingoAtlético Sant |
| |
| 29 Sep 21 | r34 | GualaceoGualaceo | 1 - 0 | LDU PortoviejoLDU Portoviej |
| |
| 06 Oct 21 | r35 | LDU PortoviejoLDU Portoviej | 1 - 0 | ChacaritasChacaritas |
| |
| 13 Oct 21 | r36 | CumbayáCumbayá | 4 - 3 | LDU PortoviejoLDU Portoviej |
Team 2021 Schedules
22 de Julio
9 de Octubre
Atlético FC
Cuenca Juniors
Cumbayá
Deportivo Santo Domingo
El Nacional
Gualaceo
Independiente Juniors
LDU Portoviejo
San Antonio FC
Vinotinto Ecuador
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