| 17 Apr 21 | r01  | CibaoCibao | 3 - 2 | JarabacoaJarabacoa |
| |
| 24 Apr 21 | r02 | Atlético San CristóbalAtlético San | 0 - 2 | CibaoCibao |
| |
| 03 May 21 | r03 | CibaoCibao | 1 - 0 | MocaMoca |
| |
| 10 May 21 | r04 | Atlético PantojaAtlético Pant | 0 - 2 | CibaoCibao |
| |
| 15 May 21 | r05 | AtlánticoAtlántico | 0 - 1 | CibaoCibao |
| |
| 28 May 21 | r07 | Universidad O&MUniversidad O | 1 - 1 | CibaoCibao |
| |
| 06 Jun 21 | r08 | CibaoCibao | 3 - 0 | Atlético San FranciscoAtlético San |
| |
| 09 Jun 21 | r09 | Atlético Vega RealAtlético Vega | 1 - 2 | CibaoCibao |
| |
| 13 Jun 21 | r10 | CibaoCibao | 3 - 0 | Atlético San CristóbalAtlético San |
| |
| 16 Jun 21 | r06 | CibaoCibao | 2 - 0 | Delfines del EsteDelfines del |
| |
| 20 Jun 21 | r11 | CibaoCibao | 1 - 0 | Atlético Vega RealAtlético Vega |
| |
| 23 Jun 21 | r12 | MocaMoca | 0 - 4 | CibaoCibao |
| |
| 27 Jun 21 | r13 | CibaoCibao | 0 - 0 | Atlético PantojaAtlético Pant |
| |
| 04 Jul 21 | r14 | CibaoCibao | 0 - 0 | Universidad O&MUniversidad O |
| |
| 07 Jul 21 | r15 | Delfines del EsteDelfines del | 1 - 3 | CibaoCibao |
| |
| 10 Jul 21 | r16 | Atlético San FranciscoAtlético San | 1 - 2 | CibaoCibao |
| |
| 16 Jul 21 | r17 | CibaoCibao | 1 - 1 | AtlánticoAtlántico |
| |
| 24 Jul 21 | r18 | JarabacoaJarabacoa | 1 - 1 | CibaoCibao |
| |
| 31 Jul 21 | r01 | CibaoCibao | 1 - 0 | JarabacoaJarabacoa |
| |
| 07 Aug 21 | r02 | CibaoCibao | 1 - 0 | MocaMoca |
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| 15 Aug 21 | r03 | Universidad O&MUniversidad O | 1 - 0 | CibaoCibao |
| |
| 22 Aug 21 | r04 | CibaoCibao | 4 - 0 | Atlético Vega RealAtlético Vega |
| |
| 28 Aug 21 | r05 | Atlético PantojaAtlético Pant | 1 - 1 | CibaoCibao |
| |
| 04 Sep 21 | r06 | JarabacoaJarabacoa | 0 - 0 | CibaoCibao |
| |
| 11 Sep 21 | r07 | MocaMoca | 0 - 2 | CibaoCibao |
| |
| 19 Sep 21 | r08 | CibaoCibao | 3 - 1 | Universidad O&MUniversidad O |
| |
| 25 Sep 21 | r09 | CibaoCibao | 0 - 2 | Atlético PantojaAtlético Pant |
| |
| 02 Oct 21 | r10 | Atlético Vega RealAtlético Vega | 1 - 0 | CibaoCibao |
| |
| 10 Oct 21 | r00 | Atlético PantojaAtlético Pant | 1 - 0 | CibaoCibao |
| 16 Oct 21 | r00 | CibaoCibao | 4 - 1 | Atlético PantojaAtlético Pant |
| 24 Oct 21 | r00 | CibaoCibao | 1 - 1 | Atlético Vega RealAtlético Vega |
| 31 Oct 21 | r00 | Atlético Vega RealAtlético Vega | 1 - 3 | CibaoCibao |
Team 2021 Schedules
Atlántico
Atlético Pantoja
Atlético San Cristóbal
Atlético Vega Real
Barcelona Atlético
Cibao
Delfines del Este
Jarabacoa
Moca
Salcedo
Santa Fe
Universidad O and M
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