| 11 Sep 21 | r01  | Omonia 29is MaiouOmonia 29is M | 2 - 1 | Ayia NapaAyia Napa |
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| 19 Sep 21 | r02 | KarmiotissaKarmiotissa | 0 - 1 | Omonia 29is MaiouOmonia 29is M |
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| 26 Sep 21 | r03 | Omonia 29is MaiouOmonia 29is M | 0 - 1 | Olympiada LympionOlympiada Lym |
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| 01 Oct 21 | r04 | OthellosOthellos | 0 - 4 | Omonia 29is MaiouOmonia 29is M |
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| 16 Oct 21 | r05 | Omonia 29is MaiouOmonia 29is M | 0 - 0 | XylotymbouXylotymbou |
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| 24 Oct 21 | r06 | Omonia AradippouOmonia Aradip | 1 - 1 | Omonia 29is MaiouOmonia 29is M |
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| 31 Oct 21 | r07 | Omonia 29is MaiouOmonia 29is M | 0 - 2 | Alki OrokliniAlki Oroklini |
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| 07 Nov 21 | r08 | Achyronas LiopetriouAchyronas Lio | 2 - 0 | Omonia 29is MaiouOmonia 29is M |
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| 21 Nov 21 | r09 | Omonia 29is MaiouOmonia 29is M | 0 - 2 | Akritas ChlorakasAkritas Chlor |
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| 28 Nov 21 | r10 | Omonia 29is MaiouOmonia 29is M | 0 - 1 | Anagennisi DeryneiaAnagennisi De |
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| 04 Dec 21 | r11 | Enosis Neon ParalimniEnosis Neon P | 2 - 0 | Omonia 29is MaiouOmonia 29is M |
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| 12 Dec 21 | r12 | Omonia 29is MaiouOmonia 29is M | 0 - 1 | OnisilosOnisilos |
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| 18 Dec 21 | r13 | ASILASIL | 2 - 2 | Omonia 29is MaiouOmonia 29is M |
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| 08 Jan 22 | r15 | Nea Salamis FamagustaNea Salamis F | 3 - 0 | Omonia 29is MaiouOmonia 29is M |
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| 15 Jan 22 | r16 | Ayia NapaAyia Napa | 0 - 2 | Omonia 29is MaiouOmonia 29is M |
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| 23 Jan 22 | r17 | Omonia 29is MaiouOmonia 29is M | 1 - 1 | KarmiotissaKarmiotissa |
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| 26 Jan 22 | r14 | Omonia 29is MaiouOmonia 29is M | 2 - 0 | Ermis AradippouErmis Aradipp |
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| 30 Jan 22 | r18 | Olympiada LympionOlympiada Lym | 0 - 3 | Omonia 29is MaiouOmonia 29is M |
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| 06 Feb 22 | r19 | Omonia 29is MaiouOmonia 29is M | 1 - 2 | OthellosOthellos |
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| 12 Feb 22 | r20 | XylotymbouXylotymbou | 0 - 1 | Omonia 29is MaiouOmonia 29is M |
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| 20 Feb 22 | r21 | Omonia 29is MaiouOmonia 29is M | 0 - 0 | Omonia AradippouOmonia Aradip |
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| 26 Feb 22 | r22 | Alki OrokliniAlki Oroklini | 0 - 0 | Omonia 29is MaiouOmonia 29is M |
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| 04 Mar 22 | r23 | Omonia 29is MaiouOmonia 29is M | 2 - 1 | Achyronas LiopetriouAchyronas Lio |
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| 12 Mar 22 | r24 | Akritas ChlorakasAkritas Chlor | 2 - 0 | Omonia 29is MaiouOmonia 29is M |
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| 19 Mar 22 | r25 | Anagennisi DeryneiaAnagennisi De | 1 - 1 | Omonia 29is MaiouOmonia 29is M |
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| 01 Apr 22 | r26 | Omonia 29is MaiouOmonia 29is M | 1 - 1 | Enosis Neon ParalimniEnosis Neon P |
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| 17 Apr 22 | r27 | OnisilosOnisilos | 2 - 1 | Omonia 29is MaiouOmonia 29is M |
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| 30 Apr 22 | r28 | Omonia 29is MaiouOmonia 29is M | 2 - 2 | ASILASIL |
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| 07 May 22 | r29 | Ermis AradippouErmis Aradipp | 0 - 2 | Omonia 29is MaiouOmonia 29is M |
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| 14 May 22 | r30 | Omonia 29is MaiouOmonia 29is M | 2 - 3 | Nea Salamis FamagustaNea Salamis F |
Team 2021-2022 Schedules
Achyronas-Onisilos
AEZ Zakakiou
APEA Akrotiri
ASIL Lysi
Ayia Napa
Chalkanoras Idaliou
Digenis Akritas Morphou
Doxa Katokopias
Ethnikos Latsion
Iraklis Gerolakkou
Karmiotissa
MEAP Nisou
Nea Salamis Famagusta
Omonia 29M
PAEEK
Spartakos Kitiou
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