| 11 Sep 21 | r01  | Anagennisi DeryneiaAnagennisi De | 0 - 3 | Nea Salamis FamagustaNea Salamis F |
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| 17 Sep 21 | r02 | Nea Salamis FamagustaNea Salamis F | 0 - 1 | Enosis Neon ParalimniEnosis Neon P |
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| 25 Sep 21 | r03 | OnisilosOnisilos | 1 - 1 | Nea Salamis FamagustaNea Salamis F |
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| 02 Oct 21 | r04 | Nea Salamis FamagustaNea Salamis F | 2 - 1 | ASILASIL |
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| 15 Oct 21 | r05 | Ermis AradippouErmis Aradipp | 3 - 2 | Nea Salamis FamagustaNea Salamis F |
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| 23 Oct 21 | r06 | Akritas ChlorakasAkritas Chlor | 0 - 0 | Nea Salamis FamagustaNea Salamis F |
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| 30 Oct 21 | r07 | Nea Salamis FamagustaNea Salamis F | 4 - 1 | Ayia NapaAyia Napa |
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| 06 Nov 21 | r08 | KarmiotissaKarmiotissa | 2 - 1 | Nea Salamis FamagustaNea Salamis F |
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| 19 Nov 21 | r09 | Nea Salamis FamagustaNea Salamis F | 3 - 0 | Olympiada LympionOlympiada Lym |
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| 27 Nov 21 | r10 | OthellosOthellos | 1 - 4 | Nea Salamis FamagustaNea Salamis F |
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| 04 Dec 21 | r11 | Nea Salamis FamagustaNea Salamis F | 3 - 0 | XylotymbouXylotymbou |
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| 11 Dec 21 | r12 | Omonia AradippouOmonia Aradip | 1 - 2 | Nea Salamis FamagustaNea Salamis F |
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| 17 Dec 21 | r13 | Nea Salamis FamagustaNea Salamis F | 0 - 2 | Alki OrokliniAlki Oroklini |
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| 08 Jan 22 | r15 | Nea Salamis FamagustaNea Salamis F | 3 - 0 | Omonia 29is MaiouOmonia 29is M |
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| 12 Jan 22 | r14 | Achyronas LiopetriouAchyronas Lio | 0 - 2 | Nea Salamis FamagustaNea Salamis F |
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| 15 Jan 22 | r16 | Nea Salamis FamagustaNea Salamis F | 3 - 2 | Anagennisi DeryneiaAnagennisi De |
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| 22 Jan 22 | r17 | Enosis Neon ParalimniEnosis Neon P | 1 - 0 | Nea Salamis FamagustaNea Salamis F |
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| 28 Jan 22 | r18 | Nea Salamis FamagustaNea Salamis F | 3 - 0 | OnisilosOnisilos |
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| 06 Feb 22 | r19 | ASILASIL | 0 - 1 | Nea Salamis FamagustaNea Salamis F |
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| 12 Feb 22 | r20 | Nea Salamis FamagustaNea Salamis F | 3 - 1 | Ermis AradippouErmis Aradipp |
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| 19 Feb 22 | r21 | Nea Salamis FamagustaNea Salamis F | 2 - 0 | Akritas ChlorakasAkritas Chlor |
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| 26 Feb 22 | r22 | Ayia NapaAyia Napa | 0 - 2 | Nea Salamis FamagustaNea Salamis F |
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| 05 Mar 22 | r23 | Nea Salamis FamagustaNea Salamis F | 0 - 2 | KarmiotissaKarmiotissa |
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| 19 Mar 22 | r25 | Nea Salamis FamagustaNea Salamis F | 4 - 1 | OthellosOthellos |
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| 06 Apr 22 | r24 | Olympiada LympionOlympiada Lym | 1 - 0 | Nea Salamis FamagustaNea Salamis F |
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| 10 Apr 22 | r26 | XylotymbouXylotymbou | 1 - 1 | Nea Salamis FamagustaNea Salamis F |
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| 17 Apr 22 | r27 | Nea Salamis FamagustaNea Salamis F | 2 - 0 | Omonia AradippouOmonia Aradip |
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| 30 Apr 22 | r28 | Alki OrokliniAlki Oroklini | 0 - 2 | Nea Salamis FamagustaNea Salamis F |
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| 07 May 22 | r29 | Nea Salamis FamagustaNea Salamis F | 3 - 0 | Achyronas LiopetriouAchyronas Lio |
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| 14 May 22 | r30 | Omonia 29is MaiouOmonia 29is M | 2 - 3 | Nea Salamis FamagustaNea Salamis F |
Team 2021-2022 Schedules
Achyronas-Onisilos
AEZ Zakakiou
APEA Akrotiri
ASIL Lysi
Ayia Napa
Chalkanoras Idaliou
Digenis Akritas Morphou
Doxa Katokopias
Ethnikos Latsion
Iraklis Gerolakkou
Karmiotissa
MEAP Nisou
Nea Salamis Famagusta
Omonia 29M
PAEEK
Spartakos Kitiou
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