| 16 Jan 21 | r01  | Real CartagenaReal Cartagen | 2 - 1 | CortuluáCortuluá |
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| 23 Jan 21 | r02 | Atlético CaliAtlético Cali | 3 - 0 | Real CartagenaReal Cartagen |
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| 01 Feb 21 | r03 | Real CartagenaReal Cartagen | 1 - 0 | Barranquilla FCBarranquilla |
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| 08 Feb 21 | r04 | ValleduparValledupar | 2 - 0 | Real CartagenaReal Cartagen |
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| 11 Feb 21 | r05 | Real CartagenaReal Cartagen | 3 - 1 | LlanerosLlaneros |
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| 15 Feb 21 | r06 | Union MagdalenaUnion Magdale | 2 - 1 | Real CartagenaReal Cartagen |
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| 19 Feb 21 | r07 | Real CartagenaReal Cartagen | 2 - 3 | Deportes QuindíoDeportes Quin |
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| 27 Feb 21 | r08 | OrsomarsoOrsomarso | 3 - 3 | Real CartagenaReal Cartagen |
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| 03 Mar 21 | r09 | Real CartagenaReal Cartagen | 1 - 1 | Boca Juniors de CaliBoca Juniors |
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| 06 Mar 21 | r10 | Tigres FCTigres FC | 0 - 0 | Real CartagenaReal Cartagen |
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| 14 Mar 21 | r11 | Real San AndrésReal San Andr | 0 - 3 | Real CartagenaReal Cartagen |
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| 22 Mar 21 | r12 | Real CartagenaReal Cartagen | 1 - 1 | Bogotá FCBogotá FC |
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| 28 Mar 21 | r13 | Fortaleza CEIFFortaleza CEI | 1 - 1 | Real CartagenaReal Cartagen |
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| 02 Apr 21 | r14 | Real CartagenaReal Cartagen | 2 - 1 | Leones FCLeones FC |
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| 09 Apr 21 | r15 | Atlético HuilaAtlético Huil | 4 - 1 | Real CartagenaReal Cartagen |
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| 28 Jul 21 | r01 | Real CartagenaReal Cartagen | 2 - 2 | ValleduparValledupar |
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| 03 Aug 21 | r02 | Boyacá Chicó F.C.Boyacá Chicó | 1 - 0 | Real CartagenaReal Cartagen |
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| 06 Aug 21 | r03 | Real CartagenaReal Cartagen | 0 - 1 | Fortaleza CEIFFortaleza CEI |
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| 14 Aug 21 | r04 | Real San AndrésReal San Andr | 2 - 2 | Real CartagenaReal Cartagen |
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| 25 Aug 21 | r05 | Real CartagenaReal Cartagen | 2 - 0 | CortuluáCortuluá |
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| 31 Aug 21 | r06 | Union MagdalenaUnion Magdale | 1 - 0 | Real CartagenaReal Cartagen |
| 31 Aug 21 | r06 | Union MagdalenaUnion Magdale | 1 - 0 | Real CartagenaReal Cartagen |
| |
| 04 Sep 21 | r07 | Real CartagenaReal Cartagen | 2 - 0 | Boca Juniors de CaliBoca Juniors |
| |
| 19 Sep 21 | r09 | Leones FCLeones FC | 2 - 0 | Real CartagenaReal Cartagen |
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| 29 Sep 21 | r10  | Real CartagenaReal Cartagen | 2 - 1 | LlanerosLlaneros |
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| 06 Oct 21 | r11 | Tigres FCTigres FC | 1 - 2 | Real CartagenaReal Cartagen |
| |
| 11 Oct 21 | r12 | Real CartagenaReal Cartagen | 3 - 1 | Barranquilla FCBarranquilla |
| 12 Oct 21 | r12 | Real CartagenaReal Cartagen | 3 - 1 | Barranquilla FCBarranquilla |
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| 20 Oct 21 | r13 | Bogotá FCBogotá FC | 0 - 0 | Real CartagenaReal Cartagen |
| 20 Oct 21 | r13 | Bogotá FCBogotá FC | 0 - 0 | Real CartagenaReal Cartagen |
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| 26 Oct 21 | r14 | Real CartagenaReal Cartagen | 1 - 1 | Atlético CaliAtlético Cali |
| 26 Oct 21 | r14 | Real CartagenaReal Cartagen | 1 - 1 | Atlético CaliAtlético Cali |
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| 30 Oct 21 | r15 | OrsomarsoOrsomarso | 1 - 1 | Real CartagenaReal Cartagen |
| |
| 08 Nov 21 | r01 | CortuluáCortuluá | 3 - 1 | Real CartagenaReal Cartagen |
| 13 Nov 21 | r01 | Real CartagenaReal Cartagen | 3 - 3 | Leones FCLeones FC |
| 18 Nov 21 | r01 | Real CartagenaReal Cartagen | 0 - 0 | Boyacá Chicó F.C.Boyacá Chicó |
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| 22 Nov 21 | r02 | Boyacá Chicó F.C.Boyacá Chicó | 4 - 0 | Real CartagenaReal Cartagen |
| 28 Nov 21 | r02 | Leones FCLeones FC | 3 - 2 | Real CartagenaReal Cartagen |
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| 06 Dec 21 | r03 | Real CartagenaReal Cartagen | 0 - 5 | CortuluáCortuluá |
Team 2021 Schedules
Atlético Cali
Barranquilla
Boca Juniors de Cali
Bogotá
Deportes Quindío
Envigado
Independiente Yumbo
Internacional de Palmira
Itagüí Leones
Orsomarso
Patriotas Boyacá
Real Cartagena
Real Cundinamarca
Real Santander
Tigres FC
Unión Magdalena
League Table
List
Poster
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= Banner Image 
= Fanart Image 
= Timeline Details