| 10 Feb 21 | r05        | Leones FCLeones FC | 1 - 1 | CortuluáCortuluá |
| 10 Feb 21 | r05        | Fortaleza CEIFFortaleza CEI | 1 - 1 | Atlético CaliAtlético Cali |
| 10 Feb 21 | r05        | OrsomarsoOrsomarso | 2 - 1 | Deportes QuindíoDeportes Quin |
| 11 Feb 21 | r05        | Atlético HuilaAtlético Huil | 1 - 0 | Tigres FCTigres FC |
| 11 Feb 21 | r05        | Bogotá FCBogotá FC | 1 - 0 | Barranquilla FCBarranquilla |
| 11 Feb 21 | r05        | Real CartagenaReal Cartagen | 3 - 1 | LlanerosLlaneros |
| 11 Feb 21 | r05        | Boca Juniors de CaliBoca Juniors | 0 - 1 | Union MagdalenaUnion Magdale |
| 11 Feb 21 | r05        | Real San AndrésReal San Andr | 0 - 1 | ValleduparValledupar |
| 05 May 21 | r05        | Leones FCLeones FC | 3 - 0 | Fortaleza CEIFFortaleza CEI |
| 06 May 21 | r05        | Atlético HuilaAtlético Huil | 1 - 1 | CortuluáCortuluá |
| 06 May 21 | r05        | Atlético HuilaAtlético Huil | 1 - 1 | CortuluáCortuluá |
| 06 May 21 | r05        | ValleduparValledupar | 0 - 1 | Deportes QuindíoDeportes Quin |
| 07 May 21 | r05        | Union MagdalenaUnion Magdale | 5 - 1 | Atlético CaliAtlético Cali |
| 20 Aug 21 | r05        | Leones FCLeones FC | 2 - 1 | Real San AndrésReal San Andr |
| 20 Aug 21 | r05        | Bogotá FCBogotá FC | 3 - 0 | OrsomarsoOrsomarso |
| 21 Aug 21 | r05        | Boca Juniors de CaliBoca Juniors | 0 - 2 | Union MagdalenaUnion Magdale |
| 22 Aug 21 | r05        | LlanerosLlaneros | 1 - 1 | Fortaleza CEIFFortaleza CEI |
| 23 Aug 21 | r05        | Tigres FCTigres FC | 0 - 1 | Boyacá Chicó F.C.Boyacá Chicó |
| 25 Aug 21 | r05        | Real CartagenaReal Cartagen | 2 - 0 | CortuluáCortuluá |
| 26 Aug 21 | r05        | Barranquilla FCBarranquilla | 2 - 1 | ValleduparValledupar |