| 05 Feb 21 | r04        | Atlético HuilaAtlético Huil | 1 - 1 | Leones FCLeones FC |
| 06 Feb 21 | r04        | Union MagdalenaUnion Magdale | 1 - 1 | OrsomarsoOrsomarso |
| 06 Feb 21 | r04        | LlanerosLlaneros | 0 - 1 | Boca Juniors de CaliBoca Juniors |
| 06 Feb 21 | r04        | Barranquilla FCBarranquilla | 1 - 0 | Real San AndrésReal San Andr |
| 06 Feb 21 | r04        | Atlético CaliAtlético Cali | 2 - 2 | Bogotá FCBogotá FC |
| 06 Feb 21 | r04        | CortuluáCortuluá | 3 - 0 | Fortaleza CEIFFortaleza CEI |
| 07 Feb 21 | r04        | Tigres FCTigres FC | 1 - 1 | Deportes QuindíoDeportes Quin |
| 08 Feb 21 | r04        | ValleduparValledupar | 2 - 0 | Real CartagenaReal Cartagen |
| 02 May 21 | r04        | Fortaleza CEIFFortaleza CEI | 2 - 3 | CortuluáCortuluá |
| 02 May 21 | r04        | ValleduparValledupar | 1 - 1 | Union MagdalenaUnion Magdale |
| 03 May 21 | r04        | Atlético HuilaAtlético Huil | 0 - 2 | Leones FCLeones FC |
| 03 May 21 | r04        | Atlético CaliAtlético Cali | - | Deportes QuindíoDeportes Quin |
| 13 Aug 21 | r04        | Atlético CaliAtlético Cali | 0 - 1 | Bogotá FCBogotá FC |
| 14 Aug 21 | r04        | Real San AndrésReal San Andr | 2 - 2 | Real CartagenaReal Cartagen |
| 14 Aug 21 | r04        | Fortaleza CEIFFortaleza CEI | 3 - 1 | Leones FCLeones FC |
| 15 Aug 21 | r04        | ValleduparValledupar | 0 - 0 | Tigres FCTigres FC |
| 16 Aug 21 | r04        | OrsomarsoOrsomarso | 0 - 0 | Barranquilla FCBarranquilla |
| 17 Aug 21 | r04        | CortuluáCortuluá | 3 - 1 | Boca Juniors de CaliBoca Juniors |
| 18 Aug 21 | r04        | Boyacá Chicó F.C.Boyacá Chicó | 0 - 0 | LlanerosLlaneros |