| 30 Jan 21 | r03        | Fortaleza CEIFFortaleza CEI | 3 - 4 | Atlético HuilaAtlético Huil |
| 30 Jan 21 | r03        | OrsomarsoOrsomarso | 0 - 0 | LlanerosLlaneros |
| 31 Jan 21 | r03        | Leones FCLeones FC | 1 - 2 | Tigres FCTigres FC |
| 31 Jan 21 | r03        | Bogotá FCBogotá FC | 2 - 3 | CortuluáCortuluá |
| 31 Jan 21 | r03        | Boca Juniors de CaliBoca Juniors | 1 - 2 | ValleduparValledupar |
| 31 Jan 21 | r03        | Deportes QuindíoDeportes Quin | 1 - 0 | Union MagdalenaUnion Magdale |
| 01 Feb 21 | r03        | Real CartagenaReal Cartagen | 1 - 0 | Barranquilla FCBarranquilla |
| 02 Feb 21 | r03        | Real San AndrésReal San Andr | 2 - 2 | Atlético CaliAtlético Cali |
| 29 Apr 21 | r03        | Leones FCLeones FC | 1 - 1 | Atlético HuilaAtlético Huil |
| 29 Apr 21 | r03        | CortuluáCortuluá | 0 - 1 | Fortaleza CEIFFortaleza CEI |
| 30 Apr 21 | r03        | Deportes QuindíoDeportes Quin | 1 - 0 | Atlético CaliAtlético Cali |
| 30 Apr 21 | r03        | Union MagdalenaUnion Magdale | 0 - 1 | ValleduparValledupar |
| 06 Aug 21 | r03        | Real CartagenaReal Cartagen | 0 - 1 | Fortaleza CEIFFortaleza CEI |
| 07 Aug 21 | r03        | Tigres FCTigres FC | 1 - 2 | OrsomarsoOrsomarso |
| 08 Aug 21 | r03        | Boca Juniors de CaliBoca Juniors | 0 - 0 | Real San AndrésReal San Andr |
| 08 Aug 21 | r03        | Barranquilla FCBarranquilla | 1 - 1 | Atlético CaliAtlético Cali |
| 09 Aug 21 | r03        | LlanerosLlaneros | 1 - 0 | ValleduparValledupar |
| 09 Aug 21 | r03        | Leones FCLeones FC | 0 - 0 | Boyacá Chicó F.C.Boyacá Chicó |
| 10 Aug 21 | r03        | Union MagdalenaUnion Magdale | 2 - 0 | CortuluáCortuluá |
| 04 Dec 21 | r03        | Fortaleza CEIFFortaleza CEI | 1 - 2 | Bogotá FCBogotá FC |
| 04 Dec 21 | r03        | LlanerosLlaneros | 1 - 2 | Union MagdalenaUnion Magdale |
| 06 Dec 21 | r03        | Real CartagenaReal Cartagen | 0 - 5 | CortuluáCortuluá |
| 06 Dec 21 | r03        | Boyacá Chicó F.C.Boyacá Chicó | 1 - 1 | Leones FCLeones FC |