| 22 Jan 21 | r02        | Barranquilla FCBarranquilla | 0 - 1 | Boca Juniors de CaliBoca Juniors |
| 23 Jan 21 | r02        | ValleduparValledupar | 3 - 4 | OrsomarsoOrsomarso |
| 23 Jan 21 | r02        | Atlético CaliAtlético Cali | 3 - 0 | Real CartagenaReal Cartagen |
| 23 Jan 21 | r02        | Leones FCLeones FC | 0 - 0 | Fortaleza CEIFFortaleza CEI |
| 23 Jan 21 | r02        | LlanerosLlaneros | 0 - 1 | Deportes QuindíoDeportes Quin |
| 25 Jan 21 | r02        | Atlético HuilaAtlético Huil | 4 - 0 | Bogotá FCBogotá FC |
| 26 Jan 21 | r02        | Tigres FCTigres FC | 1 - 1 | Union MagdalenaUnion Magdale |
| 24 Feb 21 | r02        | CortuluáCortuluá | 1 - 0 | Real San AndrésReal San Andr |
| 23 Apr 21 | r02        | CortuluáCortuluá | 3 - 1 | Atlético HuilaAtlético Huil |
| 25 Apr 21 | r02        | Fortaleza CEIFFortaleza CEI | 3 - 1 | Leones FCLeones FC |
| 25 Apr 21 | r02        | Atlético CaliAtlético Cali | 1 - 1 | Union MagdalenaUnion Magdale |
| 27 Apr 21 | r02        | Deportes QuindíoDeportes Quin | 2 - 1 | ValleduparValledupar |
| 30 Jul 21 | r02        | Atlético CaliAtlético Cali | 2 - 1 | Tigres FCTigres FC |
| 31 Jul 21 | r02        | Real San AndrésReal San Andr | 3 - 3 | Union MagdalenaUnion Magdale |
| 31 Jul 21 | r02        | ValleduparValledupar | 1 - 1 | Leones FCLeones FC |
| 01 Aug 21 | r02        | Bogotá FCBogotá FC | 2 - 0 | Barranquilla FCBarranquilla |
| 02 Aug 21 | r02        | Fortaleza CEIFFortaleza CEI | 3 - 0 | Boca Juniors de CaliBoca Juniors |
| 02 Aug 21 | r02        | OrsomarsoOrsomarso | 0 - 2 | LlanerosLlaneros |
| 03 Aug 21 | r02        | Boyacá Chicó F.C.Boyacá Chicó | 1 - 0 | Real CartagenaReal Cartagen |
| 17 Nov 21 | r02        | Bogotá FCBogotá FC | 2 - 1 | Union MagdalenaUnion Magdale |
| 19 Nov 21 | r02        | Fortaleza CEIFFortaleza CEI | 3 - 1 | LlanerosLlaneros |
| 22 Nov 21 | r02        | Boyacá Chicó F.C.Boyacá Chicó | 4 - 0 | Real CartagenaReal Cartagen |
| 23 Nov 21 | r02        | Leones FCLeones FC | 0 - 0 | CortuluáCortuluá |
| 23 Nov 21 | r02        | Union MagdalenaUnion Magdale | 4 - 1 | Bogotá FCBogotá FC |
| 23 Nov 21 | r02        | LlanerosLlaneros | 0 - 1 | Fortaleza CEIFFortaleza CEI |
| 27 Nov 21 | r02        | CortuluáCortuluá | 1 - 0 | Boyacá Chicó F.C.Boyacá Chicó |
| 28 Nov 21 | r02        | Leones FCLeones FC | 3 - 2 | Real CartagenaReal Cartagen |
| 28 Nov 21 | r02        | Union MagdalenaUnion Magdale | 1 - 0 | Fortaleza CEIFFortaleza CEI |
| 30 Nov 21 | r02        | Bogotá FCBogotá FC | 1 - 3 | LlanerosLlaneros |