| 13 Feb 21 | r06        | Atlético CaliAtlético Cali | 2 - 3 | Leones FCLeones FC |
| 14 Feb 21 | r06        | LlanerosLlaneros | 0 - 0 | Real San AndrésReal San Andr |
| 14 Feb 21 | r06        | CortuluáCortuluá | 0 - 0 | Atlético HuilaAtlético Huil |
| 15 Feb 21 | r06        | Tigres FCTigres FC | 2 - 0 | OrsomarsoOrsomarso |
| 15 Feb 21 | r06        | ValleduparValledupar | 6 - 0 | Bogotá FCBogotá FC |
| 15 Feb 21 | r06        | Barranquilla FCBarranquilla | 1 - 2 | Fortaleza CEIFFortaleza CEI |
| 15 Feb 21 | r06        | Union MagdalenaUnion Magdale | 2 - 1 | Real CartagenaReal Cartagen |
| 16 Feb 21 | r06        | Deportes QuindíoDeportes Quin | 1 - 1 | Boca Juniors de CaliBoca Juniors |
| 16 Jun 21 | r06        | CortuluáCortuluá | 3 - 0 | Leones FCLeones FC |
| 16 Jun 21 | r06        | Fortaleza CEIFFortaleza CEI | 0 - 2 | Atlético HuilaAtlético Huil |
| 17 Jun 21 | r06        | Deportes QuindíoDeportes Quin | 2 - 0 | Union MagdalenaUnion Magdale |
| 17 Jun 21 | r06        | Atlético CaliAtlético Cali | 0 - 1 | ValleduparValledupar |
| 28 Aug 21 | r06        | Real San AndrésReal San Andr | 3 - 1 | LlanerosLlaneros |
| 28 Aug 21 | r06        | Fortaleza CEIFFortaleza CEI | 2 - 1 | Tigres FCTigres FC |
| 28 Aug 21 | r06        | OrsomarsoOrsomarso | 1 - 2 | Atlético CaliAtlético Cali |
| 29 Aug 21 | r06        | CortuluáCortuluá | 1 - 0 | Leones FCLeones FC |
| 30 Aug 21 | r06        | ValleduparValledupar | 0 - 2 | Bogotá FCBogotá FC |
| 31 Aug 21 | r06        | Union MagdalenaUnion Magdale | 1 - 0 | Real CartagenaReal Cartagen |
| 31 Aug 21 | r06        | Union MagdalenaUnion Magdale | 1 - 0 | Real CartagenaReal Cartagen |
| 01 Sep 21 | r06        | Boyacá Chicó F.C.Boyacá Chicó | 1 - 1 | Barranquilla FCBarranquilla |