| 15 Jan 21 | r01        | Union MagdalenaUnion Magdale | 1 - 2 | LlanerosLlaneros |
| 16 Jan 21 | r01        | Real CartagenaReal Cartagen | 2 - 1 | CortuluáCortuluá |
| 16 Jan 21 | r01        | OrsomarsoOrsomarso | 2 - 2 | Barranquilla FCBarranquilla |
| 17 Jan 21 | r01        | Boca Juniors de CaliBoca Juniors | 1 - 1 | Atlético CaliAtlético Cali |
| 17 Jan 21 | r01        | Deportes QuindíoDeportes Quin | 1 - 2 | ValleduparValledupar |
| 03 Feb 21 | r01        | Fortaleza CEIFFortaleza CEI | 2 - 0 | Tigres FCTigres FC |
| 17 Feb 21 | r01        | Real San AndrésReal San Andr | 2 - 2 | Atlético HuilaAtlético Huil |
| 18 Feb 21 | r01        | Bogotá FCBogotá FC | 1 - 3 | Leones FCLeones FC |
| 17 Apr 21 | r01        | ValleduparValledupar | 3 - 0 | Atlético CaliAtlético Cali |
| 17 Apr 21 | r01        | Leones FCLeones FC | 3 - 3 | CortuluáCortuluá |
| 17 Apr 21 | r01        | Atlético HuilaAtlético Huil | 3 - 0 | Fortaleza CEIFFortaleza CEI |
| 21 Apr 21 | r01        | Union MagdalenaUnion Magdale | 1 - 1 | Deportes QuindíoDeportes Quin |
| 23 Jul 21 | r01        | Boca Juniors de CaliBoca Juniors | 0 - 1 | Boyacá Chicó F.C.Boyacá Chicó |
| 24 Jul 21 | r01        | LlanerosLlaneros | 0 - 0 | Atlético CaliAtlético Cali |
| 24 Jul 21 | r01        | Leones FCLeones FC | 1 - 0 | OrsomarsoOrsomarso |
| 25 Jul 21 | r01        | Tigres FCTigres FC | 0 - 0 | Bogotá FCBogotá FC |
| 26 Jul 21 | r01        | Union MagdalenaUnion Magdale | 3 - 1 | Fortaleza CEIFFortaleza CEI |
| 28 Jul 21 | r01        | Real CartagenaReal Cartagen | 2 - 2 | ValleduparValledupar |
| 01 Sep 21 | r01        | CortuluáCortuluá | 2 - 0 | Real San AndrésReal San Andr |
| 05 Nov 21 | r01        | Bogotá FCBogotá FC | 1 - 4 | Fortaleza CEIFFortaleza CEI |
| 07 Nov 21 | r01        | Union MagdalenaUnion Magdale | 0 - 0 | LlanerosLlaneros |
| 08 Nov 21 | r01        | CortuluáCortuluá | 3 - 1 | Real CartagenaReal Cartagen |
| 10 Nov 21 | r01        | Leones FCLeones FC | 0 - 0 | Boyacá Chicó F.C.Boyacá Chicó |
| 13 Nov 21 | r01        | Fortaleza CEIFFortaleza CEI | 0 - 0 | Union MagdalenaUnion Magdale |
| 13 Nov 21 | r01        | Real CartagenaReal Cartagen | 3 - 3 | Leones FCLeones FC |
| 14 Nov 21 | r01        | LlanerosLlaneros | 2 - 0 | Bogotá FCBogotá FC |
| 15 Nov 21 | r01        | Boyacá Chicó F.C.Boyacá Chicó | 1 - 0 | CortuluáCortuluá |
| 18 Nov 21 | r01        | CortuluáCortuluá | 2 - 0 | Leones FCLeones FC |
| 18 Nov 21 | r01        | Real CartagenaReal Cartagen | 0 - 0 | Boyacá Chicó F.C.Boyacá Chicó |