| 14 Aug 21 | Playoff  | Blauw Geel 38Blauw Geel 38 | 1 - 2 | FC LisseFC Lisse |
| 14 Aug 21 | Playoff | HVV HollandiaHVV Hollandia | 1 - 5 | ACVACV |
| 14 Aug 21 | Playoff | HSC 21HSC 21 | 1 - 1 | Excelsior 31Excelsior 31 |
| 14 Aug 21 | Playoff | AFC Ajax AmateursAFC Ajax Amat | 2 - 1 | RKVV EVVRKVV EVV |
| 14 Aug 21 | Playoff | JOS WatergraafsmeerJOS Watergraa | 1 - 5 | Ter LeedeTer Leede |
| 14 Aug 21 | Playoff | RKVV DEMRKVV DEM | 1 - 1 | Sparta NijkerkSparta Nijker |
| 21 Sep 21 | Playoff | DVS 33 ErmeloDVS 33 Ermelo | 2 - 2 | VV NoordwijkVV Noordwijk |
| 21 Sep 21 | Playoff | HSV ODIN 59HSV ODIN 59 | 1 - 2 | De TreffersDe Treffers |
| 21 Sep 21 | Playoff | FC LisseFC Lisse | 1 - 2 | Amsterdamsche FCAmsterdamsche |
| 21 Sep 21 | Playoff | IJsselmeervogelsIJsselmeervog | 3 - 1 | Sportlust 46Sportlust 46 |
| 21 Sep 21 | Playoff | Sparta NijkerkSparta Nijker | 2 - 0 | VV SliedrechtVV Sliedrecht |
| 21 Sep 21 | Playoff | VV KatwijkVV Katwijk | 2 - 3 | Harkemase BoysHarkemase Boy |
| 21 Sep 21 | Playoff | Quick BoysQuick Boys | 0 - 2 | Rijnsburgse BoysRijnsburgse B |
| 21 Sep 21 | Playoff | HHC HardenbergHHC Hardenber | 0 - 2 | VV CapelleVV Capelle |
| 21 Sep 21 | Playoff | VV GoesVV Goes | 1 - 2 | VV DOVOVV DOVO |
| 21 Sep 21 | Playoff | Achilles VeenAchilles Veen | 3 - 2 | DTS 35 EdeDTS 35 Ede |
| 21 Sep 21 | Playoff | AFC Ajax AmateursAFC Ajax Amat | 4 - 1 | VVSBVVSB |
| 21 Sep 21 | Playoff | VV ASWHVV ASWH | 1 - 0 | Quick Den HaagQuick Den Haa |
| 21 Sep 21 | Playoff | GVVVGVVV | 3 - 1 | VVOGVVOG |
| 21 Sep 21 | Playoff | HSV HoekHSV Hoek | 2 - 3 | SteDoCoSteDoCo |
| 21 Sep 21 | Playoff | BVV BarendrechtBVV Barendrec | 3 - 0 | SVV ScheveningenSVV Schevenin |
| 22 Sep 21 | Playoff | Kozakken BoysKozakken Boys | 2 - 0 | RKSV Groene SterRKSV Groene S |
| 22 Sep 21 | Playoff | GVV UnitasGVV Unitas | 1 - 0 | Ter LeedeTer Leede |
| 22 Sep 21 | Playoff | VV GemertVV Gemert | 3 - 1 | SV TECSV TEC |
| 22 Sep 21 | Playoff | SV OSS 20SV OSS 20 | 2 - 1 | HSC 21HSC 21 |
| 22 Sep 21 | Playoff | VV HooglandVV Hoogland | 0 - 1 | RKVV WestlandiaRKVV Westland |
| 22 Sep 21 | Playoff | USV HerculesUSV Hercules | 1 - 1 | ACVACV |
| 22 Sep 21 | Playoff | ADO 20ADO 20 | 2 - 1 | Koninklijke HFCKoninklijke H |
| 22 Sep 21 | Playoff | VV StaphorstVV Staphorst | 3 - 1 | VV DongenVV Dongen |
| 22 Sep 21 | Playoff | SV SpakenburgSV Spakenburg | 5 - 2 | VV UNAVV UNA |
| 22 Sep 21 | Playoff | OFC OostzaanOFC Oostzaan | 0 - 2 | Excelsior MaassluisExcelsior Maa |
Team 2021-2022 Schedules
Aalsmeer
ARC Alphen
De Foresters
DVO Sittard
Halsteren
Heino
HZVV
Juliana '31
Mierlo-Hout
Olde Veste '54
Poortugaal
Sportclub '25
Sportclub 't Zand
Velocitas
Walcheren
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