| 18 Apr 21 | r02  | Deportes Santa CruzDeportes Sant | 2 - 2 | Universidad de ConcepciónUniversidad d |
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| 26 Apr 21 | r03 | Santiago MorningSantiago Morn | 1 - 3 | Deportes Santa CruzDeportes Sant |
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| 03 May 21 | r04 | Deportes Santa CruzDeportes Sant | 1 - 0 | Deportes Puerto MonttDeportes Puer |
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| 10 May 21 | r05 | Deportes TemucoDeportes Temu | 0 - 1 | Deportes Santa CruzDeportes Sant |
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| 19 May 21 | r06 | Deportes Santa CruzDeportes Sant | 1 - 7 | Coquimbo UnidoCoquimbo Unid |
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| 25 May 21 | r07 | Unión San FelipeUnión San Fel | 1 - 0 | Deportes Santa CruzDeportes Sant |
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| 30 May 21 | r08 | Deportes Santa CruzDeportes Sant | 1 - 3 | Deportes IquiqueDeportes Iqui |
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| 07 Jun 21 | r09 | Deportes CopiapóDeportes Copi | 2 - 0 | Deportes Santa CruzDeportes Sant |
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| 11 Jul 21 | r10 | Deportes Santa CruzDeportes Sant | 2 - 0 | San Luis de QuillotaSan Luis de Q |
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| 15 Jul 21 | r11 | Rangers de TalcaRangers de Ta | 1 - 3 | Deportes Santa CruzDeportes Sant |
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| 21 Jul 21 | r12 | Deportes Santa CruzDeportes Sant | 2 - 0 | MagallanesMagallanes |
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| 24 Jul 21 | r01 | Deportes Santa CruzDeportes Sant | 2 - 3 | Lautaro de BuinLautaro de Bu |
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| 03 Aug 21 | r13 | BarnecheaBarnechea | 0 - 0 | Deportes Santa CruzDeportes Sant |
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| 08 Aug 21 | r14 | CobreloaCobreloa | 0 - 1 | Deportes Santa CruzDeportes Sant |
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| 15 Aug 21 | r15 | Deportes Santa CruzDeportes Sant | 2 - 0 | San Marcos de AricaSan Marcos de |
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| 27 Aug 21 | r17 | Universidad de ConcepciónUniversidad d | 0 - 1 | Deportes Santa CruzDeportes Sant |
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| 01 Sep 21 | r18 | Deportes Santa CruzDeportes Sant | 1 - 1 | Santiago MorningSantiago Morn |
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| 05 Sep 21 | r19 | Deportes Puerto MonttDeportes Puer | 2 - 2 | Deportes Santa CruzDeportes Sant |
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| 14 Sep 21 | r20  | Deportes Santa CruzDeportes Sant | 1 - 0 | Deportes TemucoDeportes Temu |
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| 24 Sep 21 | r21 | Coquimbo UnidoCoquimbo Unid | 0 - 0 | Deportes Santa CruzDeportes Sant |
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| 28 Sep 21 | r22 | Deportes Santa CruzDeportes Sant | 0 - 1 | Unión San FelipeUnión San Fel |
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| 03 Oct 21 | r23 | Deportes IquiqueDeportes Iqui | 6 - 1 | Deportes Santa CruzDeportes Sant |
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| 08 Oct 21 | r24 | Deportes Santa CruzDeportes Sant | 1 - 2 | Deportes CopiapóDeportes Copi |
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| 12 Oct 21 | r25 | San Luis de QuillotaSan Luis de Q | 0 - 0 | Deportes Santa CruzDeportes Sant |
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| 19 Oct 21 | r26 | Deportes Santa CruzDeportes Sant | 1 - 0 | Rangers de TalcaRangers de Ta |
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| 23 Oct 21 | r27 | MagallanesMagallanes | 1 - 1 | Deportes Santa CruzDeportes Sant |
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| 01 Nov 21 | r28 | Deportes Santa CruzDeportes Sant | 2 - 0 | BarnecheaBarnechea |
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| 06 Nov 21 | r29 | Deportes Santa CruzDeportes Sant | 2 - 2 | CobreloaCobreloa |
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| 13 Nov 21 | r30 | San Marcos de AricaSan Marcos de | 0 - 0 | Deportes Santa CruzDeportes Sant |
Team 2021 Schedules
Cobreloa
Curicó Unido
Deportes Antofagasta
Deportes Copiapó
Deportes Iquique
Deportes Puerto Montt
Deportes Recoleta
Deportes Santa Cruz
Deportes Temuco
Magallanes
Rangers de Talca
San Luis de Quillota
San Marcos de Arica
Santiago Wanderers
Unión Española
Unión San Felipe
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